Cardiovascular autonomic function and vibration perception threshold in type 2 diabetes mellitus
Abstract
Objective The aim of this study was to compare cardiovascular autonomic function tests (AFT) and vibration perception threshold (VPT) of patients with type 2 diabetes mellitus (T2DM) with controls.Research design/methods The study was conducted on 60 diabetic patients comparing with 30 controls. The cardiovascular AFT and VPT were assessed in both groups.Results Among cardiovascular AFT, E:I ratio [1.24 (1.2-1.32) vs 1.3 (1.24-1.4), p=0.001], and Valsalva ratio [1.28 (1.22-1.4) vs 1.6 (1.5-1.73), p=0.001], the indicators of parasympathetic reactivity were reduced in T2DM. Rise in DBP during handgrip, an indicator of sympathetic reactivity was lower in T2DM [12 (10-14) vs 16 (14-18) mmHg, p=0.001] whereas, fall in SBP during head up tilt [4 (4-8) vs 5 (4-8) mmHg] was comparable. VPT (somatic sensation) was comparable between T2DM and control.Conclusion Autonomic involvement is more marked than somatic, and parasympathetic involvement is more marked than the sympathetic, possibly reflecting severity and chronological pattern of their involvement.
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The metaregression finding that time from diagnosis of T2DM was linked with higher SDNN is not contradictory to the decreased SDNN in T2DM but may simply highlight that cardiac parasympathetic activity in T2DM is affected before sympathetic activity.
“Despite we demonstrated a decreased SDNN in T2DM patients, the metaregression is not contradictory but may simply highlights the fact that cardiac parasympathetic activity in T2DM is affected before sympathetic activity [80].”
From Heart rate variability in type 2 diabetes mellitus: A systematic review and meta–analysis (2018) · cites this paper as [80]
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Heart rate variability and vibration perception threshold in type 2 diabetes mellitus
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- Authors
- Goit, R. K., Khadka, R., Sharma, S. K., Limbu, N., & Paudel, B. H.
- Affiliations
- B.P. Koirala Institute of Health Sciences (NP)
- Corresponding author
- Goit, Rajesh Kumar
- Venue
- Journal of Diabetes and its Complications
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 26
- Issue
- 4
- Pages
- 339-342
- ISSN
- 0891-6632 (ISSN-L)
- 1056-8727
- OpenAlex
- W2109852524
- Cited by
- 12
- References
- 18
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2014: 2 · 2013: 1
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Diabetes and its Complications (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- type 2 diabetes, cardiac autonomic dysfunction, vibration perception threshold, parasympathetic reactivity, sympathetic response, heart rate variability, E/I ratio, Valsalva ratio, somatic sensation
- MeSH terms
- Adult, Autonomic Nervous System, Blood Pressure, Cardiovascular System, Diabetes Mellitus, Type 2, Humans, Male, Middle Aged, Sensory Thresholds, Sympathetic Nervous System, Vibration, Case-Control Studies, Tilt-Table Test, Hand Strength, Touch Perception, Respiratory Rate
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