Cited by 134Dental Erosion and TreatmentOral microbiology and periodontitis researchDental Health and Care Utilization

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Acquired salivary pellicle and oral diseases: A literature review

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Chawhuaveang, Darren Dhananthat, Yu, Ollie Yiru, Yin, Iris Xiaoxue, Lam, Walter Yu-Hang, Mei, May Lei, Chu, Chun-Hung·2021·Journal of Dental Sciences

DOI 10.1016/j.jds.2020.10.007PMC PMC7770358

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Abstract

As soon as saliva contacts the teeth surface, salivary proteins adhere to the tooth surface to form acquired salivary pellicle. The formation of this acquired salivary pellicle is a dynamic and selective process of macromolecular adsorption and desorption. Although acquired salivary pellicle contains proteins and peptides, it also contains lipids, and other macro-molecules, all of which contribute to its protective properties. Acquired salivary pellicle is related to the development of common oral diseases, such as erosion, dental caries, and periodontal disease. Acquired salivary pellicle acts as a natural barrier to prevent a tooth's surface from making direct contact with acids and to protect it from erosive demineralization. It contributes to the control of dental erosion by modulating calcium and phosphate concentrations on the tooth surface. It also influences the initial colonizer of oral biofilm and affects the transportation pathway of the acidic products of cariogenic bacteria, which affects the development of dental caries. In addition, it influences periodontal disease by acting on the colonization of periodontal pathogens. This paper's aim is to provide an overview of the acquired salivary pellicle, highlighting its composition, structure, function, role in common oral diseases, and modification for the prevention of oral diseases.

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Figure 1 Formation of acquired salivary pellicle A: Clean enamel surface B: Initial stage: attachment of precursor proteins (seconds to a couple of minutes) C: Developing stage: protein–protein reaction (within 45 min) D: Maturation stage: the equilibrium between adsorption and desorption (within 120 min).CC BY-NC-ND · PubMed Central

Figure 2 The schematic structure of acquired salivary pellicle.CC BY-NC-ND · PubMed Central

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Authors: Chawhuaveang, D. D., Yu, O. Y., Yin, I. X., Lam, W. Y.-H., Mei, M. L., & Chu, C.-H.
Affiliations: University of Hong Kong (HK)
University of Otago (NZ)
Corresponding author: Chu, Chun-Hung
ORCID: Chawhuaveang, Darren Dhananthat
Yu, Ollie Yiru
Yin, Iris Xiaoxue
Lam, Walter Yu-Hang
Mei, May Lei
Venue: Journal of Dental Sciences
Publisher: Elsevier BV
Published: 2021-01
Volume: 16
Issue: 1
Pages: 523-529
ISSN: 1991-7902 (ISSN-L)
DOI: 10.1016/j.jds.2020.10.007
PMC: PMC7770358
OpenAlex: W3094233644
Cited by: 134
References: 39
Citations by year: 2026: 21 · 2025: 27 · 2024: 35 · 2023: 22 · 2022: 20 · 2021: 9
FWCI: 3.09
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Journal of Dental Sciences (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: General Research Fund of Research Grants Council of Hong Kong SAR, China (17100820)
Topics: Health Sciences › Dentistry › General Dentistry › Dental Erosion and Treatment
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Health Sciences › Dentistry › General Dentistry › Dental Health and Care Utilization
Keywords: salivary proteins, dental erosion, dental caries, periodontal disease, dental plaque, demineralization, calcium and phosphate, cariogenic bacteria, periodontal pathogens, oral disease prevention

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Acquired salivary pellicle and oral diseases: A literature review

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