CoChat
Sign Up
Cited by 32Heart Rate Variability and Autonomic ControlCardiac electrophysiology and arrhythmiasCardiac pacing and defibrillation studies

Heart rate turbulence and other autonomic risk markers for arrhythmia risk stratification in dilated cardiomyopathy

Klingenheben, Thomas, Ptaszynski, Pawel, Hohnloser, Stefan H.·2008·Journal of Electrocardiology
DOI 10.1016/j.jelectrocard.2007.10.004
Open this paper in CoChat — free account

Abstract

Background Noninvasive arrhythmia risk stratification in patients with nonischemic dilated cardiomyopathy (DCM) using autonomic markers have yielded disappointing results. Heart rate turbulence is a new method to assess cardiac autonomic function.Aim The aim of the study was to compare the predictive value of heart rate turbulence with those of conventional autonomic risk markers for ventricular tachyarrhythmic events in patients with DCM.Methods The predictive value of heart rate turbulence, baroreflex sensitivity (phenylephrine method), and heart rate variability was assessed in patients with symptomatic congestive heart failure due to DCM who were in sinus rhythm and had a 24-hour Holter recording. Patients were followed for a combined end point of ventricular tachyarrhythmic events.Results A total of 114 patients (mean left ventricular ejection fraction, 28 +/- 11%), included in the Frankfurt DCM database between 1996 and 2000, fulfilled the criteria for inclusion in this study. Determinate test results were obtained for heart rate variability in 98%, for baroreflex sensitivity in 90%, and for heart rate turbulence in 75% of patients (P = .008). Correlation between the different autonomic markers were only modest (r values, 0.36-0.43). During a follow-up of 22 +/- 17 months, an end point event occurred in 15 patients. On univariate analysis, left ventricular ejection fraction and baroreflex sensitivity were significant predictors of arrhythmic events. On multivariate analysis, only baroreflex sensitivity remained an independent predictor (chi(2) = 3.17; P = .07).Conclusion Reliable analysis of heart rate turbulence is possible in approximately 75% of eligible patients with DCM. Whereas blunted baroreflex sensitivity is a predictor of arrhythmic events, heart rate variability and turbulence do not yield predictive power in these patients.

Integrity signals

Registry

Crossref · 10.1016/j.jelectrocard.2007.10.004

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In nonischemic cardiomyopathy, blunted baroreflex activity is a significant predictor of arrhythmic events, but heart rate variability and turbulence did not yield predictive power.

    “In this disease a blunted baroreflex activity was a significant predictor of arrhythmic events but heart rate variability and turbulence did not yield predictive power in their patients.43”

    From The Year of 2008 in Electrocardiology (2010) · cites this paper as [43]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Klingenheben, T., Ptaszynski, P., & Hohnloser, S. H.
Affiliations
Goethe University Frankfurt (DE)
Corresponding author
Klingenheben, Thomas
ORCID
Venue
Journal of Electrocardiology
Publisher
Elsevier BV
Published
2008-07
Volume
41
Issue
4
Pages
306-311
ISSN
0022-0736 (ISSN-L)
DOI
10.1016/j.jelectrocard.2007.10.004
OpenAlex
W2039701499
Cited by
32
References
28
Citations by year
2026: 2 · 2023: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 2 · 2015: 2 · 2014: 5 · 2013: 3 · 2012: 3
FWCI
2.17
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Electrocardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Keywords
heart rate turbulence, baroreflex sensitivity, heart rate variability, dilated cardiomyopathy, arrhythmic risk stratification, ventricular tachyarrhythmia, cardiac autonomic function, left ventricular ejection fraction, congestive heart failure, prognostic factors
MeSH terms
Arrhythmias, Cardiac, Autonomic Nervous System Diseases, Cardiomyopathy, Dilated, Electrocardiography, Female, Germany, Humans, Male, Middle Aged, Risk Factors, Sensitivity and Specificity, Reproducibility of Results, Comorbidity, Incidence, Risk Assessment

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review