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Effect of Mexican medicinal plant used to treat trichomoniasis on Trichomonas vaginalis trophozoites
Abstract
Crude methanolic extracts from 22 Mexican medicinal plants were screened for antitrichomonal activity against Trichomonas vaginalis, which is the etiological agent of trichomoniasis. Among the plants tested Carica papaya and Cocos nucifera showed the best antitrichomonal activity with IC(50) values of 5.6 and 5.8 microg/ml, respectively. The extracts of Bocconia frutescens, Geranium mexicanum, and Lygodium venustum showed moderate activity with IC(50) values ranging from 30.9 to 60.9 microg/ml. All the other plant extracts were inactive (IC(50)>100 microg/ml). All extracts tested were less active than metronidazole (IC(50) 0.037 microg/ml), an antiprotozoal drug used as positive control. The results of the antiprotozoal screening support the popular uses of five of the plants tested for the treatment of some urogenital tract disorders in Mexican traditional medicine. However, seeds of Carica papaya and aerial parts of Bocconia frutescens should be used in herbal medicine with care to avoid toxicity.
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“In Mexico, coconut is used to treat various disorders associated with urogenital tract infection by Trichomonas vaginalis (24).”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [24]
In the citing paper
“The crude methanol extract of C. nucifera husk fiber demonstrated excellent antitrichomonal activity (IC50 value of 5.8 μg/mL), standing out among the other tested plants, although the activity was less than that of metronidazole.”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [24]
In the citing paper
“The experiments were performed in duplicate and repeated at least three times.”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [24]
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Metadata
- Authors
- Calzada, F., Yépez-Mulia, L., & Tapia-Contreras, A.
- Affiliations
- Mexican Social Security Institute (MX)
- Corresponding author
- Calzada, Fernando
- ORCID
- Calzada, Fernando
- Venue
- Journal of Ethnopharmacology
- Publisher
- Elsevier BV
- Published
- 2007-09
- Volume
- 113
- Issue
- 2
- Pages
- 248-251
- ISSN
- 0378-8741 (ISSN-L)
- OpenAlex
- W1967091783
- Cited by
- 120
- References
- 21
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 2 · 2023: 5 · 2022: 7 · 2021: 3 · 2020: 9 · 2019: 11 · 2018: 2 · 2017: 7 · 2016: 7 · 2015: 11 · 2014: 15 · 2013: 7 · 2012: 6
- FWCI
- 5.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Ethnopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Ethnobotanical and Medicinal Plants Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry Medicinal Plant Applications
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Keywords
- Trichomonas vaginalis, trichomoniasis, antitrichomonal activity, medicinal plants, plant extracts, Carica papaya, Cocos nucifera, Bocconia frutescens, Lygodium venustum, metronidazole, traditional medicine, genitourinary diseases, toxicity
- MeSH terms
- Methanol, Animals, Antiprotozoal Agents, Antitrichomonal Agents, Cocos, Metronidazole, Mexico, Plant Extracts, Plants, Medicinal, Seeds, Trichomonas vaginalis, Inhibitory Concentration 50, Papaveraceae, Carica, Geranium, Plant Components, Aerial, Rats, Trophozoites
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