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Cited by 43

The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.

Sauropus androgynus L. Merr.-A phytochemical, pharmacological and toxicological review

Zhang, Bo-dou, Cheng, Jia-xin, Zhang, Chao-feng, Bai, Yi-dan, Liu, Wen-yuan, Li, Wei, Koike, Kazuo, Akihisa, Toshihiro, Feng, Feng, Zhang, Jie·2020·Journal of Ethnopharmacology
DOI 10.1016/j.jep.2020.112778
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Abstract

ETHNOPHARMACOLOGICAL RELEVANCE Sauropus androgynus L. Merr is an underexploited perennial shrub traditionally used as a medicinal plant in South Asia and Southeast Asia. The plant is regarded as not just a green vegetable for diet but a traditional herb for certain aliments. For instance, it has traditionally been used to relieve fever, to treat ulcers and diabetes, to promote lactation and eyesight, as well as reducing obesity. AIM OF THE STUDY This paper aims to review the botany, phytochemistry, ethnopharmacology and pharmacological activities of S. androgynus and discuss the known chemical constituents combined with S. androgynus-induced bronchiolitis obliterans for providing new ideas to the following mechanism of the disease and pharmacology research of the plant. MATERIALS AND METHODS The data presented in this review were collected from published literatures as well as the electronic databases of PubMed, CNKI, Web of Science, SCI finder, ACS, Science Direct, Wiley, Springer, Taylor, Google Scholar and a number of unpublished resources, (e.g. books, Ph.D. and M.Sc. dissertations). RESULTS The scientific literature indicates that S. androgynous is a valuable and popular herbal medicine whose nutritional value is also higher than that of other commonly used vegetable. Phytochemical analyses identified high content of flavonoids and polyphenols as the major bioactive substances in S. androgynous. Crude extracts and phytochemical constituents isolated from S. androgynus show a wide spectrum of in vitro and in vivo pharmacological activities like antioxidant, anti-inflammatory, anti-ulcer, skin whitening, anti-diabetic and immunoregulatory. The tradition uses, such as increasing lactation, treating ulcers and diabetes, and reducing obesity, have been evaluated and studied with various methods. Numerous reports have been revealed the unusual link between the consumption of S. androgynus and induction of a chronic and irreversible obstructive disease (namely bronchiolitis obliterans), indicating that the toxicity and side effects of the plant presently used in health care and medicine are a major area of concern. CONCLUSION Though little importance of this multigreen plant was attached, S. androgynus has notable phytochemical constituents and various pharmacological activities including antioxidant, anti-inflammatory, anti-obesity activities. Studies have firmly established the association between excessive consumption of the uncooked S. androgynus juice over a period of time and the occurrence of bronchiolitis obliterans. It is unsuited to ingestion of excessive S. androgynous before fully understanding the pathogenesis and induction mechanism of this fatal disease. S. androgynus-induced bronchiolitis obliterans, phytochemistry together with of pharmacology for traditional uses of S. androgynus still needed further investigation.

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Citations

Cites

Research works printed but not linked: 16

  1. Bender, 1973, Nutritive value and toxicity of Sauropus androgynus, Proc. Nutr. Soc., 32, 79A
  2. Benjapak, 2008, Determination of antioxidant capacity and nutritive values of Pak-Wanban (Sauropus androgynus L. Merr.), Khon-Kean Univers. Sci. J., 36, 279
  3. Gayathramma, 2012, Chemical constituents and antimicrobial activities of certain plant parts of Sauropus androgynus L, Int. J. Pharma Bio Sci., 3, 561
  4. Han, 2010, The industry development status and countermeasures of Sauropus androgynus in Hainan province. China, Veg. Times, 1, 11
  5. Kumar, 2016, Activity of Sauropus androgynus L. leaf extract against inflammation and its immunomodulatory effect in Swiss albino mice, Int. J. Adv. Biotechnol. Res., 2, 621
  6. Lee, 1998, Woody and wild plants of Sauropus androgynus, Guangdong Agric. Sci., 18
  7. Lee, 2006, Cytotoxicity and genotoxicity of Sauropus androgynus, Chin. J. Health Lab. Technol., 16, 1050
  8. Liao, 1996, Fatty acid composition of the seed oil from Sauropus androgynus L, Merr. J. Trop. Subtrop. Bot., 3, 70
  9. Lin, 1999, Study on chemical constituents of the essential oil from the leaves of Sauropus androgynus L, Merr. J. Trop. Subtrop. Bot., 255
  10. Paul, 2011, Antibacterial activity of Sauropus androgynus (L.) Merr, Int. J. Plant Sci., 6, 189
  11. Selvi, 2011, Antifungal activity and phytochemical analysis of Cympogon citratus, Sauropus androgynus and Spillanthes acmella plants, World J. Fun. Plant Bio., 2, 6
  12. Turner, 1965, Anti-inflammatory agent, vol. 13, 158
  13. Wang, 2009, The pathological effect of Sauropus androgynus powder on testes of male rats fed on 90d, J. Toxicol., 23, 464
  14. Xiong, 2011, Evaluation of toxicity and safty of Sauropus androgynus, Chin. J. Public Health, 12, 1553
  15. Yang, 2002, South China wild vegetable nutritive composition, Food Sci. (N. Y.), 11, 121
  16. Yao, 2006, Enrichment of heavy metal elements in 8 kinds of wild vegetables, China Veg., 20

Metadata

Authors
Zhang, B.-D., Cheng, J.-X., Zhang, C.-F., Bai, Y.-D., Liu, W.-Y., Li, W., Koike, K., Akihisa, T., Feng, F., & Zhang, J.
Venue
Journal of Ethnopharmacology
Publisher
Elsevier BV
Published
2020-07
Volume
257
Pages
112778
ISSN
0378-8741
DOI
10.1016/j.jep.2020.112778
Cited by
43
References
86
Language
en
Licence
  • www.elsevier.com/tdm/userlicense/1.0/ (tdm)
  • www.elsevier.com/legal/tdmrep-license (tdm)
Funders
  • National Outstanding Youth Science Fund Project of National Natural Science Foundation of China (81703383)
  • Natural Science Foundation of Jiangsu Province (BK20170742)
  • National Natural Science Foundation of China
  • Fundamental Research Funds for the Central Universities (2632019ZD16)
  • Double First Class University Plan (CPU2018GY34)

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