Coconut kernel protein in diet protects the heart by beneficially modulating endothelial nitric oxide synthase, tumor necrosis factor-alpha, and nuclear factor-kappaB expressions in experimental myocardial infarction
Open accessAbstract
Abstract Previous studies conducted in our laboratory revealed that coconut kernel protein has a significant cardioprotective effect on isoproterenol-induced myocardial infarction in rats. In the present study, we explored the possible protective mechanism of coconut kernel protein during acute myocardial infarction. Coconut kernel protein (50 mg/100 g) was administered to Sprague-Dawley rats orally for 45 days. Isoproterenol (20 mg/100 g) was injected subcutaneously at an interval of 24 hours twice to induce myocardial infarction. Myocardial infarction was confirmed by the abnormal activities of cardiac marker enzymes in serum. Activities of antioxidant enzymes such as superoxide dismutase (SOD) and catalase were decreased ( p p p
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Diets containing coconut kernel protein (CKP) exhibit anti-inflammatory effects.
“studies have revealed that diets containing coconut kernel protein (CKP) exhibit cardioprotective [163], hypolipidemic, antioxidant, and anti-inflammatory effects [164] against myocardial infarction”
From Nutritional composition and bioactive properties of tropical coconut palm fruit with functional food applications (2025) · cites this paper as [164]
Diets containing coconut kernel protein (CKP) exhibit hypolipidemic effects.
“studies have revealed that diets containing coconut kernel protein (CKP) exhibit cardioprotective [163], hypolipidemic, antioxidant, and anti-inflammatory effects [164] against myocardial infarction”
From Nutritional composition and bioactive properties of tropical coconut palm fruit with functional food applications (2025) · cites this paper as [164]
Diets containing coconut kernel protein (CKP) exhibit antioxidant effects.
“studies have revealed that diets containing coconut kernel protein (CKP) exhibit cardioprotective [163], hypolipidemic, antioxidant, and anti-inflammatory effects [164] against myocardial infarction”
From Nutritional composition and bioactive properties of tropical coconut palm fruit with functional food applications (2025) · cites this paper as [164]
Cites
Prince, P. S. M., Suman, S., Devika, P. T., & Vaithianathan, M. (2008) · Fitoterapia · doi:10.1016/j.fitote.2008.01.009 · Cited by 42 · see citing works
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Ajibola, O. O. (2025) · Discover Food · doi:10.1007/s44187-025-00746-3 · Cited by 3 · see citing works
“Additionally, studies have revealed that diets containing coconut kernel protein (CKP) exhibit cardioprotective [163], hypolipidemic, antioxidant, and anti-inflammatory effects [164] against myocardial infarction, further affirming CKP as a medicinal food.”
- Authors
- Remya, S., Chikku, A. M., Renjith, R. S., Arunima, S., & Rajamohan, T.
- Affiliations
- University of Kerala (IN)
- Venue
- Journal of Food and Drug Analysis
- Published
- 2013-09
- Volume
- 21
- Issue
- 3
- Pages
- 325-331
- ISSN
- 1021-9498 (ISSN-L)
- OpenAlex
- W2000390073
- Cited by
- 23
- References
- 1
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2022: 2 · 2021: 2 · 2020: 2 · 2018: 3 · 2017: 1 · 2016: 4 · 2015: 2
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Food and Drug Analysis (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Inorganic Chemistry › Coconut Research and Applications
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- cardioprotection, myocardial infarction, endothelial nitric oxide synthase, TNF-α, nuclear factor-kappaB, isoproterenol-induced myocardial infarction, antioxidant enzymes, superoxide dismutase, catalase, dietary protein
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