Cardioprotective effect of ‘Marutham’a polyherbal formulation on isoproterenol induced myocardial infarction in Wistar rats
Abstract
Myocardial infarction is the number one killer disease in many parts of the world. The cardioprotective effect of Marutham, a polyherbal formulation on serum and heart tissue lipids, serum lipoproteins and heart membrane bound enzymes in isoproterenol induced myocardial infarction was studied in Wistar rats. Pretreatment with Marutham at different doses of 30, 60 and 90 mg kg(-1) to isoproterenol treated rats significantly prevented the altered lipid profile and membrane bound enzymes to near normal status. The results of our study showed the cardioprotective potential of Marutham on isoproterenol induced myocardial infarction in rats.
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HPLC analysis revealed a possible role of withaferin-A in the neuroprotective activity of WS root extract.
“High-performance liquid chromatography (HPLC) analysis revealed the possible role of withaferin-A in the neuroprotective activity of WS root extract [274].”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [274]
Root extract has neuroprotective activity in Swiss albino mice.
“| Root extract | Neuroprotection | Swiss albino mice | Decrease in Bcl-2, increase in Bax | [274] |”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [274]
Root extract decreases Bcl-2 in Swiss albino mice.
“| Root extract | Neuroprotection | Swiss albino mice | Decrease in Bcl-2, increase in Bax | [274] |”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [274]
Root extract increases Bax in Swiss albino mice.
“| Root extract | Neuroprotection | Swiss albino mice | Decrease in Bcl-2, increase in Bax | [274] |”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [274]
WS root extract decreases iNOS in mice.
“| WS root extract | Neuroprotective activity | Mice | Decrease in iNOS | [274] |”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [274]
WS root extract has neuroprotective activity in mice.
“| WS root extract | Neuroprotective activity | Mice | Decrease in iNOS | [274] |”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [274]
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works
A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189 · see citing works
A Receptor-Mediated Pathway for Cholesterol Homeostasis
Brown, M. S., & Goldstein, J. L. (1986) · Science · doi:10.1126/science.3513311 · Cited by 5,703 · see citing works
Incidence of coronary heart disease and lipoprotein cholesterol levels. The Framingham Study
Castelli, W. P. (1986) · JAMA · doi:10.1001/jama.256.20.2835 · Cited by 2,305 · see citing works
Incidence of Coronary Heart Disease and Lipoprotein Cholesterol Levels
Castelli, W. P. (1986) · JAMA · doi:10.1001/jama.1986.03380200073024 · Cited by 1,620 · see citing works
Microdetermination of plasma phospholipids by trichloroacetic acid precipitation.
Zilversmit, D. B., & Davis, A. K. (1950) · PubMed · Cited by 873 · see citing works
An easy colorimetric micromethod for routine determination of free fatty acids in plasma
Falholt, K., Lund, B., & FALHOLT, W. (1973) · Clinica Chimica Acta · doi:10.1016/0009-8981(73)90016-8 · Cited by 636 · see citing works
Foster, L. B., & Dunn, R. T. (1973) · Clinical Chemistry · doi:10.1093/clinchem/19.3.338 · Cited by 623 · see citing works
Cholesterol and coronary heart disease. A new era
Grundy, S. M. (1986) · JAMA · doi:10.1001/jama.256.20.2849 · Cited by 430 · see citing works
Hjertén, S., & Pan, H.-Z. (1983) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(83)90480-7 · Cited by 377 · see citing works
Cholesterol and Coronary Heart Disease
Grundy, S. M. (1986) · JAMA · doi:10.1001/jama.1986.03380200087027 · Cited by 288 · see citing works
Okinaka, S. (1961) · Archives of Neurology · doi:10.1001/archneur.1961.00450110050006 · Cited by 285 · see citing works
Buring, J. E., O'Connor, G. T., Goldhaber, S. Z., ROSNER, B. A., Herbert, P. N., Blum, C. B., Breslow, J. L., & Hennekens, C. H. (1992) · Circulation · doi:10.1161/01.cir.85.1.22 · Cited by 224 · see citing works
Buhl, S. N., & Jackson, K. Y. (1978) · Clinical Chemistry · doi:10.1093/clinchem/24.5.828 · Cited by 191 · see citing works
Wilson, D. E., & Spiger, M. J. (1973) · PubMed · Cited by 160 · see citing works
Sushamakumari, S., Jayadeep, A., Kumar, J. S. S., & Menon, V. P. (1989) · PubMed · Cited by 109 · see citing works
Vajreswari, A., & Narayanareddy, K. (1992) · Lipids · doi:10.1007/bf02536147 · Cited by 51 · see citing works
Paritha, I. A., & Shyamala, D. C. (1997) · Indian Journal of Pharmacology · Cited by 47 · see citing works
Kumari, S. S., Varghese, A., Muraleedharan, D., & Menon, V. P. (1990) · PubMed · Cited by 38 · see citing works
Mathew, S. S., Pv, M., & Kurup, P. A. (1981) · PubMed · Cited by 29 · see citing works
Effect of aspirin on isoproterenol induced changes in lipid metabolism in rats.
Manjula, T. S., & Cs, D. (1993) · PubMed · Cited by 20 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Pharmacologic overview of Withania somnifera, the Indian Ginseng
Dar, N. J., Hamid, A., & Ahmad, M. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2012-1 · Cited by 391 · see citing works
Paul, S., Chakraborty, S., Anand, U., Dey, S., Nandy, S., Ghorai, M., Saha, S. C., Patil, M. T., Kandimalla, R., Proćków, J., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112175 · Cited by 306 · see citing works
Saleem, S., Muhammad, G., Hussain, M. A., Altaf, M., & Bukhari, S. N. A. (2020) · Europe PMC (PubMed Central) · doi:10.22038/ijbms.2020.44254.10378 · Cited by 197 · see citing works
Mandlik, D. S., & Namdeo, A. G. (2020) · Journal of Dietary Supplements · doi:10.1080/19390211.2020.1741484 · Cited by 149 · see citing works
Isoproterenol Induced Myocardial Infarction: Protective Role of Natural Products
Upaganlawar, A., Gandhi, H., & Balaraman, R. (2010) · Journal of Pharmacology and Toxicology · doi:10.3923/jpt.2011.1.17 · Cited by 124 · see citing works
Wong, Z. W., Thanikachalam, P. V., & Ramamurthy, S. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.08.009 · Cited by 124 · see citing works
Al‐Yahya, M. A., Mothana, R. A., Alsaid, M. S., El-Tahir, K., Al-Sohaibani, M. O., & Rafatullah, S. (2013) · Nutrients · doi:10.3390/nu5114269 · Cited by 56 · see citing works
Alam, N., Hossain, M., Khalil, M. I., Moniruzzaman, M., Sulaiman, S. A., & Gan, S. H. (2011) · Phytochemistry Reviews · doi:10.1007/s11101-011-9221-5 · Cited by 55 · see citing works
Zhao, X., Dou, M., Zhang, Z., Zhang, D., & Huang, C. Z. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.07.096 · Cited by 48 · see citing works
Shaik, A. H., Rasool, N., Reddy, A. V. K., Kareem, M. A., Krushna, G. S., & Devi, K. L. (2012) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2012.01.011 · Cited by 46 · see citing works
Paulino, E. T., Ferreira, A. K. B., da Silva, J. C. G., Costa, C. D. F., Smaniotto, S., de Araújo‐Júnior, J. X., da Silva‐Júnior, E. F., Bortoluzzi, J. H., & Ribeiro, Ê. A. N. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112037 · Cited by 37 · see citing works
Li, C., Gao, Y., Tian, J., Xing, Y., Zhu, H., & Shen, J. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.01.024 · Cited by 35 · see citing works
Goyal, S. N., Siddiqui, M. K., Siddiqui, K. M., Arora, S., Mittal, R., Joshi, S., & Arya, D. S. (2009) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2009.02.115 · Cited by 35 · see citing works
Thounaojam, M. C., Jadeja, R. N., Ansarullah, M., Karn, S. S., Shah, J. D., Patel, D., Salunke, S. P., Padate, G. S., Devkar, R., & Ramachandran, A. V. (2010) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2010.02.010 · Cited by 34 · see citing works
Kumari, S., Mittal, A., & Dabur, R. (2016) · Steroids · doi:10.1016/j.steroids.2016.03.016 · Cited by 31 · see citing works
Cardioprotective potential of biobased gold nanoparticles
Vinodhini, A., Govindaraju, K., Singaravelu, G., Sadiq, A. M., & Kumar, V. G. (2014) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2014.01.006 · Cited by 28 · see citing works
Adebayo, A. H., Zeng, G., Fan, J., Ji, C., He, W., Xu, J., Zhang, Y., Akindahunsi, A. A., Kela, R., & Tan, N. (2010) · Covenant University Repository (Covenant University) · doi:10.5897/jmpr10.470 · Cited by 24 · see citing works
Reddy, K., Subbaiah, G., Korivi, M., Shanmugam, B., Ravi, S., & Taj, P. (2017) · Pharmacognosy Magazine · doi:10.4103/0973-1296.203891 · Cited by 23 · see citing works
Remya, S., Chikku, A. M., Renjith, R. S., Arunima, S., & Rajamohan, T. (2013) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2013.07.012 · Cited by 23 · see citing works
Arya, D. S., Arora, S., Malik, S., Nepal, S., Kumari, S., & Ojha, S. K. (2010) · Toxicology Mechanisms and Methods · doi:10.3109/15376516.2010.514962 · Cited by 23 · see citing works
Asimi, O. A., & Np, S. (2016) · Journal of Fisheries & Livestock Production · doi:10.4172/2332-2608.1000157 · Cited by 20 · see citing works
Patel, N. G., Patel, K. G., Patel, K. V., & Gandhi, T. R. (2015) · Advances in Pharmacological Sciences · doi:10.1155/2015/682365 · Cited by 18 · see citing works
Cinar, I., Halıcı, Z., Dinçer, B., Sirin, B., & Cadirci, E. (2020) · Human & Experimental Toxicology · doi:10.1177/0960327120916821 · Cited by 17 · see citing works
Patra, K. C., Kumar, K. J., & Ahirwar, D. K. (2013) · Journal of Natural Medicines · doi:10.1007/s11418-013-0792-x · Cited by 16 · see citing works
Evaluation of cardioprotective effects of Parkia biglobosa (Jacq. Benth) Mimosaceae stem bark
Adi, K. (2013) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2013.30210 · Cited by 16 · see citing works
Shaik, A. H., Mohammed, A. K., Sammeturi, M., Alomar, S. Y., Altaf, M., & Kodidhela, L. D. (2019) · Journal of King Saud University - Science · doi:10.1016/j.jksus.2019.09.015 · Cited by 16 · see citing works
Mulla, A. N., Thorat, S. T., Chandramore, K., Kumar, P., Reddy, K. S., & Kumar, N. (2025) · Scientific Reports · doi:10.1038/s41598-025-95369-0 · Cited by 15 · see citing works
Sah, D. K., & Nagarathana, P. K. M. (2016) · International Journal of Pharmacological Research · doi:10.7439/ijpr.v6i1.2898 · Cited by 9 · see citing works
Jain, V., Chaturvedi, S., Jamil, S., Tyagi, R., Arya, S., & Madan, S. (2024) · Nutrition & Food Science · doi:10.1108/nfs-01-2024-0030 · Cited by 5 · see citing works
Evaluation of Shivaksharpachan Churna for its Gastroprotective Activity
Patra, K. C., Pareta, S. K., Harwansh, R. K., & Kumar, M. (2011) · Cited by 2 · see citing works
Adi, K., Metowogo, K., Eklu‐Gadegbeku, K., Lamboni, C., Gado, N.-K., Kodjo, A. A., & Gbéassor, M. (2013) · Pakistan Journal of Nutrition · doi:10.3923/pjn.2013.322.328 · Cited by 2 · see citing works
Role of Polyherbal Formulations for Management of Cardiovascular Diseases
Jahan, N., Hassan, R., Shamshad, H., Saleem, A., Fatima, A., & Pullaiah, T. (2024) · Springer eBooks · doi:10.1007/978-981-97-4627-9_10 · Cited by 1 · see citing works
Cardioprotective Potential of Wedelia chinensi on Isoproterenol Induced Myocardial Rat
Monisha, M. S. S., Ragavan, B., & Rex, D. A. B. (2014) · Asian Journal of Biochemistry · doi:10.3923/ajb.2014.98.106 · Cited by 1 · see citing works
Adeyanju, A. O., Adedokun, O. K., Ige, A. S., Awotide, Y. E., & Aderibigbe, E. Y. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4875354 · Cited by 1 · see citing works
WITHDRAWN: Varying levels and function of several biological macromolecules in myocardium
Zhang, J., & Tao, W. (2013) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2013.06.019
Pilli, R., Koilagundla, N., Ramakanth, G. S. H., & Pingali, U. (2016) · International Journal of Basic & Clinical Pharmacology · doi:10.18203/2319-2003.ijbcp20161538
Sudhakar, P., Kumar, R. S., Kothai, R., & Arul, B. (2022) · Indian Journal of Pharmaceutical Sciences · doi:10.36468/pharmaceutical-sciences.925
Adoption of biotechnologies for Withania somnifera (L.) Dunal for sustainable utilization
Shah, S., Vashisth, D., Shasany, A. K., Ambati, R. R., & Ravishankar, G. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-21818-7.00013-7
Thangaraju, P., Saraswathy, T., Velmurugan, H., Venkatesan, S., Y, S. S. T., Maheshwari, P., Sargunam, R. R., Srinivasan, A., Thangaraju, E., & Tamilselvan, T. (2024) · Infectious Disorders - Drug Targets · doi:10.2174/0118715265296476241018050329
Management of Heart Failure with Reduced Ejection Fraction Using Siddha Medicine: A Case Report
Priya, U. D., & Gowri, M. (2025) · Journal of MedVerse Research & Practice · doi:10.65188/nurexus.1040
Abdel‐Ghany, H. M., Almisherfi, H. M., Helal, A. M., Henish, S., & Salem, M. E. (2026) · Journal of Comparative Physiology B · doi:10.1007/s00360-026-01685-w
- Authors
- Prince, P. S. M., Suman, S., Devika, P. T., & Vaithianathan, M.
- Affiliations
- Annamalai University (IN)
- Corresponding author
- Prince, Ponnian Stanely Mainzen
- Venue
- Fitoterapia
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 79
- Issue
- 6
- Pages
- 433-438
- ISSN
- 0367-326X (ISSN-L)
- OpenAlex
- W2002742222
- Cited by
- 42
- References
- 21
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 3 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 2 · 2013: 6 · 2012: 2
- FWCI
- 1.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Fitoterapia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- polyherbal formulation, cardioprotection, myocardial infarction, isoproterenol-induced cardiotoxicity, serum lipids, lipoproteins, herbal medicine
- MeSH terms
- Animals, Cardiotonic Agents, Hyperlipidemias, Isoproterenol, Lipids, Lipoproteins, Male, Phytotherapy, Membrane Proteins, Myocardial Infarction, Myocardium, Rats, Wistar, Plant Preparations, Rats, Plant Exudates
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