Lactic acid bacteria and probiotic organisms induce different cytokine profile and regulatory T cells mechanisms
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Probiotic-induced cytokine production, including IL-1β, IL-6, TNF-α, and interferons, has been linked to excessive immune reactions that can lead to autoimmune disorders or inflammation.
“Recent studies have linked probiotic-induced cytokine production, such as interleukins IL-1β, IL-6, tumor necrosis factor TNF-α, and interferons, to excessive immune reactions that can lead to autoimmune disorders or inflammation [12,86].”
From Current Concepts in Probiotic Safety and Efficacy (2026) · cites this paper as [86]
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Current Concepts in Probiotic Safety and Efficacy
Churin, A. A., Sokolyanskaya, L. O., Lukina, A. P., & Karnachuk, O. V. (2026) · Nutrients · doi:10.3390/nu18040696 · Cited by 31 · see citing works
“Recent studies have linked probiotic-induced cytokine production, such as interleukins IL-1 β , IL-6, tumor necrosis factor TNF-α , and interferons, to excessive immune reactions that can lead to autoimmune disorders or inflammation [12,86].”
Liu, W., Zhang, S., Dong, C., Lv, X., Zheng, X., Zhao, W., Jamali, M., Abedi, R., & Saedisomeolia, A. (2025) · Nutrition & Metabolism · doi:10.1186/s12986-025-01002-2 · Cited by 9 · see citing works
- Authors
- Ashraf, R., Vasiljevic, T., Day, S. L., Smith, S. C., & Donkor, O. N.
- Affiliations
- Victoria University (AU)
- Burnet Institute (AU)
- Corresponding author
- Donkor, O.N.
- Venue
- Journal of Functional Foods
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 6
- Pages
- 395-409
- ISSN
- 1756-4646 (ISSN-L)
- OpenAlex
- W1966417737
- Cited by
- 62
- References
- 77
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 7 · 2023: 5 · 2022: 8 · 2021: 5 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 5 · 2015: 4 · 2014: 4
- FWCI
- 6.46
- Type
- journal article
- Language
- en
- Open access
- green
- doaj.org
- Licence
- Locations
- Journal of Functional Foods (publishedVersion)
- Victoria University Research Repository (Victoria University) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Victoria University-Australian Postgraduate Research Award
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- lactic acid bacteria, probiotics, immunomodulation, cytokine profile, regulatory T cells, Foxp3, IL-10, TGF-beta, TNF-α, interferon-gamma, Lactobacillus casei, Streptococcus thermophilus, Bifidobacterium animalis subsp. lactis, peripheral blood mononuclear cells, strain-specific immune response
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