Fermented soy milk prepared using kefir grains prevents and ameliorates obesity, type 2 diabetes, hyperlipidemia and liver-kidney toxicities in HFFD-rats
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In vitro, this study showed that unfermented soy milk (USM) and kefir fermented soy milk (FSM) inhibited pancreas lipase with (IC50 = 52.17 and 39.37 μg/mL) and α-amylase activities with (IC50 = 72.60 and 52.71 μg/mL respectively). The most powerful lipase and α -amylase inhibitory activity was observed around 16 h of fermentation. In HFFD rats, the supplement of FSM increased locomotor performance; and decreased intestinal and pancreas lipase activity by 34 and 35% as compared to untreated HDF-rats. This leads to decrease in TC and LDL-c by 24 and 66%; and increase in HDL-c rates of HFFD-rats by 32%, which helped to decrease in body weight by 20%. Moreover administration of FSM to HFFD-rats inhibited intestinal and pancreas α-amylase activity by 26 and 31% as compared to untreated HFFD-rats, and consequently decrease of blood glucose by 36%. In addition, FSM efficiently was protected from hepatic and kidney tissues toxicities.
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In the in vitro analysis, the study showed the ability of kefir to inhibit α-amylase and pancreatic lipase.
“In the in vitro analysis, the study showed the ability of kefir to inhibit α-amylase and pancreatic lipase.”
From Kefir and Intestinal Microbiota Modulation: Implications in Human Health (2021) · cites this paper as [39]
Kefir could act against obesity by inhibiting enzymes related to the digestion of carbohydrates and lipids, which will result in less energy release.
“Kefir could act against obesity by inhibiting enzymes related to the digestion of carbohydrates and lipids, which will result in less energy release.”
From Kefir and Intestinal Microbiota Modulation: Implications in Human Health (2021) · cites this paper as [39]
In the in vivo section, the obese animals treated with the fermented drink were more stimulated to perform physical activity.
“In the in vivo section, the obese animals treated with the fermented drink were more stimulated to perform physical activity.”
From Kefir and Intestinal Microbiota Modulation: Implications in Human Health (2021) · cites this paper as [39]
Inhibition of intestinal and pancreatic α-amylase activity and, consequently, decreased blood glucose and protection of liver and kidney tissues from toxicity were also observed after kefir consumption; that is, this fermented drink was able to reverse parameters related to obesity.
“Inhibition of intestinal and pancreatic α-amylase activity and, consequently, decreased blood glucose and protection of liver and kidney tissues from toxicity were also observed after kefir consumption; that is, this fermented drink was able to reverse parameters related to obesity (39).”
From Kefir and Intestinal Microbiota Modulation: Implications in Human Health (2021) · cites this paper as [39]
Intestinal and pancreatic lipase activity decreased in the groups receiving kefir, leading to a reduction in total cholesterol and LDL-cholesterol, and an increase in HDL-cholesterol rates, as well as body weight loss.
“Intestinal and pancreatic lipase activity decreased in the groups receiving kefir, leading to a reduction in total cholesterol and LDL-cholesterol, and an increase in HDL-cholesterol rates, as well as body weight loss.”
From Kefir and Intestinal Microbiota Modulation: Implications in Human Health (2021) · cites this paper as [39]
Cites
Hamden, K., Elfeki, A., Ayadi, F., Jamoussi, K., & Masmoudi, H. (2008) · BioFactors · doi:10.1002/biof.5520330302 · Cited by 43 · see citing works
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Kefir and Intestinal Microbiota Modulation: Implications in Human Health
Peluzio, M. D. C. G., Dias, M. D. M. E., Martinez, J. A., & Milagro, F. I. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.638740 · Cited by 92 · see citing works
- Authors
- Tiss, M., Souiy, Z., Abdeljelil, N. B., Njima, M., Achour, L., & Hamden, K.
- Affiliations
- University of Monastir (TN)
- Corresponding author
- Hamden, Khaled
- Venue
- Journal of Functional Foods
- Publisher
- Elsevier BV
- Published
- 2020-04
- Volume
- 67
- Pages
- 103869
- ISSN
- 1756-4646 (ISSN-L)
- OpenAlex
- W3009156766
- Cited by
- 97
- References
- 1
- Citations by year
- 2026: 10 · 2025: 22 · 2024: 13 · 2023: 18 · 2022: 15 · 2021: 13 · 2020: 5
- FWCI
- 8.27
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Functional Foods (publishedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Tunisian Ministry of Higher Education and Scientific Research and Technology
- Tunisian Ministry of public heath
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- fermented soymilk, kefir grains, high-fat high-sugar diet, obesity, type 2 diabetes, hyperlipidemia, α-amylase inhibition, blood glucose, lipid profile, hepatotoxicity, nephrotoxicity, locomotor performance, body weight
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