Cited by 43Natural Antidiabetic Agents StudiesPhytochemical Studies and BioactivitiesMedicinal Plant Research

Therapeutic effect of phytoecdysteroids rich extract from Ajuga iva on alloxan induced diabetic rats liver, kidney and pancreas

Hamden, Khaled, Elfeki, Abdelfattah, Ayadi, Fatma, Jamoussi, Kamel, Masmoudi, Hatem·2008·BioFactors

Abstract

In the current study, the effect of Ajuga iva extract on blood glucose, lipid profile, hepatic and renal toxicity and antioxidant enzyme activities in alloxan-induced diabetic rats was investigated. Diabetes was confirmed by measuring the glucoserua concentration 15 days after alloxan administration. Ajuga iva extract was administrated orally 3 weeks after alloxan injection. Our results investigate that Ajuga iva extract supplementation increased the levels of both enzymatic antioxidant (superoxide dismutase, catalase and glutathione peroxidase) and metals antioxidants (iron, copper, magnesium, calcium) and decreased lipid peroxidation level (TBARs). Besides Ajuga iva ameliorated diabetes provoked hepatic and renal toxicity appeared by a lower level in total and direct bilirubin, urea, creatinine, triglyceride (TG), cholesterol and a higher level in HDL-cholesterol. Besides, the activities of phosphatase alkalines (PAL), aspartate and lactate transaminase (AST & ALT) were decreased. The benefices effects of phytoecdysteroids of Ajuga iva confirmed by histological observation in pancreatic tissues. In conclusion, Ajuga iva phytoecdysteroids supplements seem to be beneficial for correcting the hyperglycemia and preventing diabetic complications in liver, pancreas and kidneys.

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Crossref · 10.1002/biof.5520330302

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Authors
Hamden, K., Elfeki, A., Ayadi, F., Jamoussi, K., & Masmoudi, H.
Affiliations
  • University of Sfax (TN)
  • Faculty of Sciences of Sfax (TN)
  • Hopital Universitaire Habib Bourguiba (TN)
Corresponding author
Hamden, Khaled
Venue
BioFactors
Publisher
Wiley
Published
2008-01
Volume
33
Issue
3
Pages
165-175
ISSN
  • 0951-6433 (ISSN-L)
  • 1872-8081
OpenAlex
W2123057728
Cited by
43
References
44
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 5 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 4
FWCI
1.69
Type
journal article
Language
en
Open access
closed
Locations
  • BioFactors (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ministère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords
Ajuga iva, phytoecdysteroids, alloxan-induced diabetes, hyperglycemia, lipid peroxidation, antioxidant enzymes, hepatotoxicity, nephrotoxicity, pancreatic histology, lipid profile, blood glucose, plant extracts
MeSH terms
Animals, Blood Glucose, Creatinine, Diabetes Mellitus, Experimental, Kidney, Lipids, Liver, Male, Pancreas, Plant Extracts, Urea, Lipid Peroxidation, Ecdysteroids, Ajuga, Rats

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