Therapeutic effect of phytoecdysteroids rich extract from Ajuga iva on alloxan induced diabetic rats liver, kidney and pancreas
Abstract
In the current study, the effect of Ajuga iva extract on blood glucose, lipid profile, hepatic and renal toxicity and antioxidant enzyme activities in alloxan-induced diabetic rats was investigated. Diabetes was confirmed by measuring the glucoserua concentration 15 days after alloxan administration. Ajuga iva extract was administrated orally 3 weeks after alloxan injection. Our results investigate that Ajuga iva extract supplementation increased the levels of both enzymatic antioxidant (superoxide dismutase, catalase and glutathione peroxidase) and metals antioxidants (iron, copper, magnesium, calcium) and decreased lipid peroxidation level (TBARs). Besides Ajuga iva ameliorated diabetes provoked hepatic and renal toxicity appeared by a lower level in total and direct bilirubin, urea, creatinine, triglyceride (TG), cholesterol and a higher level in HDL-cholesterol. Besides, the activities of phosphatase alkalines (PAL), aspartate and lactate transaminase (AST & ALT) were decreased. The benefices effects of phytoecdysteroids of Ajuga iva confirmed by histological observation in pancreatic tissues. In conclusion, Ajuga iva phytoecdysteroids supplements seem to be beneficial for correcting the hyperglycemia and preventing diabetic complications in liver, pancreas and kidneys.
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Phytoecdysteroids have beneficial effects on mammals, including anabolic, adaptogenic, antidiabetic, hypolipidemic, and hepatoprotective effects.
“They are known for their numerous beneficial effects on mammals, which include as anabolic, adaptogenic, antidiabetic, hypolipidemic, and hepatoprotective effects150, 151, 152, 153.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [152]
20-HE enhances keratinocyte differentiation, increases protein synthesis via Akt activation, and inhibits collagenase activity in vitro.
“Additionally, 20-HE was also found to enhance keratinocyte differentiation153, increase protein synthesis via Akt activation159, and inhibit collagenase activity in vitro152.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [152]
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- Authors
- Hamden, K., Elfeki, A., Ayadi, F., Jamoussi, K., & Masmoudi, H.
- Affiliations
- University of Sfax (TN)
- Faculty of Sciences of Sfax (TN)
- Hopital Universitaire Habib Bourguiba (TN)
- Corresponding author
- Hamden, Khaled
- ORCID
- Hamden, Khaled
- Venue
- BioFactors
- Publisher
- Wiley
- Published
- 2008-01
- Volume
- 33
- Issue
- 3
- Pages
- 165-175
- ISSN
- 0951-6433 (ISSN-L)
- 1872-8081
- OpenAlex
- W2123057728
- Cited by
- 43
- References
- 44
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 5 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 4
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- BioFactors (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- Ajuga iva, phytoecdysteroids, alloxan-induced diabetes, hyperglycemia, lipid peroxidation, antioxidant enzymes, hepatotoxicity, nephrotoxicity, pancreatic histology, lipid profile, blood glucose, plant extracts
- MeSH terms
- Animals, Blood Glucose, Creatinine, Diabetes Mellitus, Experimental, Kidney, Lipids, Liver, Male, Pancreas, Plant Extracts, Urea, Lipid Peroxidation, Ecdysteroids, Ajuga, Rats
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