Skin health functionality evaluation of collagen peptide with the application of meta-analytical approach
Open accessAbstract
• The effect size of skin wrinkles was more than a small effect level (SMD < −0.2). The SMD of R3 and Ra, which correspond to the average value, showed the largest value. • Skin hydration significantly increased on the cheek site measured by the corneometer, which is predominantly used for the measurement of skin moisture. The effect size of skin hydration was above the moderate effect level (SMD > 0.5). • Skin elasticity of all parameters is above the moderate effect level (SMD > 0.5). A meta-analytical technique was applied to the evaluation of the functionality of collagen peptide health functional food ingredients (n = 6, until Feb. ’23) recognized in Korea for 7 interventions, with a total of 564 participants. The effect size was assessed using the standardized mean difference (SMD), and detailed subgroup analyses were conducted in the presence of heterogeneity. As a result of evaluating functionality, effective results were shown in the test group compared with placebo in terms of skin wrinkles (SMD < −0.2), skin hydration (SMD > 0.5), and skin elasticity (SMD > 0.5). R3 and R a , which are the parameters of average skin roughness measured by the visiometer and the PRIMOS respectively, showed the largest SMD. Skin hydration significantly increased on the cheek site measured by the corneometer, which is predominantly used for the measurement of skin moisture. The scientific evidence for the skin-related functionalities of recognized collagen peptides was confirmed through meta-analytical approaches.
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Previous randomized controlled trials and meta-analyses have reported improvements in skin elasticity following oral or topical interventions, including collagen peptides and other bioactive compounds.
“Although previous randomized controlled trials and meta-analyses have reported improvements in skin elasticity following oral or topical interventions, including collagen peptides and other bioactive compounds [43,44,45,46,47,48]”
The direction of change observed in the present study (increased skin hydration following supplementation) is generally consistent with previous reports.
“Although the direction of change observed in the present study (i.e., increased skin hydration following supplementation) is generally consistent with previous reports [43,44,45,46,47,48]”
Recent randomized controlled trials evaluating oral or topical bioactive compounds-including collagen peptides and other nutraceutical ingredients-have demonstrated improvements in wrinkle-related parameters assessed using validated quantitative techniques.
“Consistent with this, recent randomized controlled trials evaluating oral or topical bioactive compounds—including collagen peptides and other nutraceutical ingredients—have demonstrated improvements in wrinkle-related parameters assessed using validated quantitative techniques [43,44,45,46,47,48].”
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Hur, N., Seo, Y., Bae, J., Kim, Y. J., Kim, E. J., & Choi, Y. J. (2026) · Nutrients · doi:10.3390/nu18101505
- Authors
- Yoon, T., Lee, H.-Y., & Jung, W.-K.
- Affiliations
- Ministry of Food and Drug Safety (KR)
- Pukyong National University (KR)
- Corresponding author
- Lee, Hye-Young
- Jung, Won-Kyo
- Venue
- Journal of Functional Foods
- Publisher
- Elsevier BV
- Published
- 2024-10
- Volume
- 121
- Pages
- 106411
- ISSN
- 1756-4646 (ISSN-L)
- OpenAlex
- W4401852015
- Cited by
- 3
- References
- 22
- Citations by year
- 2026: 2 · 2024: 1
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Functional Foods (publishedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Research Foundation of Korea
- Ministry of Education (2021R1A6A1A03039211)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
- Keywords
- collagen peptides, skin health, wrinkles, skin hydration, skin elasticity, skin roughness, standardized mean difference
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