The DOI matches its Crossref record; 70 of the 71 references it cites were found in a registry or an index.
Mitigation of honokiol on fluoride-induced mitochondrial oxidative stress, mitochondrial dysfunction, and cognitive deficits through activating AMPK/PGC-1α/Sirt3
Abstract
Oxidative stress and mitochondrial dysfunction contribute greatly to fluoride-induced cognitive impairment and behavioural disorders. Honokiol, a natural biphenolic compound, possesses antioxidant and mitochondrial protective properties. The present study investigated the protective actions of honokiol on NaF-elicited cognitive deficits and elucidated the possible mechanism of honokiol-mediated protection. The results demonstrated that honokiol administration markedly attenuated fluoride-induced cognitive impairments and neural/synaptic injury in mice. Moreover, honokiol elevated the activity and expression of SOD2 and promoted mtROS scavenging through Sirt3 activation in NaF-treated mice and SH-SY5Y cell lines. Meanwhile, honokiol substantially lowered mtROS production by enhancing Sirt3-mediated mitochondrial DNA (mtDNA) transcription, thereby leading to significant increases in ATP synthesis and complex I activity. Further studies revealed that honokiol activated AMPK and upregulated the PGC-1α and Sirt3 protein expression in vivo and in vitro. Intriguingly, the protective actions of honokiol on oxidative stress and mitochondrial dysfunction were abolished by AMPK shRNA or Sirt3 shRNA. Notably, AMPK knockdown prevented the increase in PGC-1α and Sirt3 expression induced by honokiol, while Sirt3 shRNA suppressed Sirt3 signaling without significant effects on p-AMPK and PGC-1α expression. In conclusion, our findings indicate that honokiol mitigates NaF-induced oxidative stress and mitochondrial dysfunction by regulating mtROS homeostasis, partly via the AMPK/PGC-1α/Sirt3 pathway, which ultimately contributes to neuronal/synaptic injury and cognitive deficits.
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“intestinal AMPK, which can directly or indirectly interact with SOD2 [24, 25]”
From Healthy Human Fecal Microbiota Transplantation into Mice Attenuates MPTP-Induced Neurotoxicity via AMPK/SOD2 Pathway (2023) · cites this paper as [25]
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The sirtuin family in health and disease
Wu, Q., Zhang, T., Chen, H., Yu, X., Lv, J.-L., Liu, Y., Liu, Y., Zheng, G., Zhao, J.-Q., Wei, Y., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01257-8 · Cited by 928
New insights into the role of mitochondrial dynamics in oxidative stress-induced diseases
Chen, S., Li, Q., Shi, H., Li, F., Duan, Y., & Guo, Q. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117084 · Cited by 250
Xie, Z., Zhang, M., Luo, Y., Jin, D., Guo, X., Yang, W., Zheng, J., Zhang, H., Zhang, L., Deng, C., et al. (2023) · Aging and disease · doi:10.14336/ad.2023.0309 · Cited by 80
“Intriguingly, intestinal AMPK, which can directly or indirectly interact with SOD2 [24, 25], was discovered to be modulated by microbiota [26].”
He, W., Tang, P., & Lv, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1571576 · Cited by 67
Wang, D., Yin, K., Zhang, Y., Lu, H., Hou, L., Zhao, H., & Xing, M. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.121847 · Cited by 57
Self-citation
Metadata
- Authors
- Wang, D., Cao, L., Zhou, X., Wang, G., Ma, Y., Hao, X., & Fan, H.
- Affiliations
- Henan University of Science and Technology (CN)
- First Affiliated Hospital of Henan University of Science and Technology (CN)
- Corresponding author
- Wang, Dongmei
- Fan, Hua
- Venue
- Journal of Hazardous Materials
- Publisher
- Elsevier BV
- Published
- 2022-09
- Volume
- 437
- Pages
- 129381
- ISSN
- 0304-3894 (ISSN-L)
- OpenAlex
- W4283010307
- Cited by
- 186
- References
- 71
- Citations by year
- 2026: 59 · 2025: 53 · 2024: 53 · 2023: 19 · 2022: 2
- FWCI
- 10.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Hazardous Materials (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Physical Sciences › Environmental Science › Water Science and Technology › Fluoride Effects and Removal
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Magnolia and Illicium research
- Keywords
- honokiol, fluoride toxicity, sodium fluoride, mitochondrial oxidative stress, mitochondrial dysfunction, cognitive impairment, AMPK, PGC-1α, SIRT3, mitochondrial reactive oxygen species, manganese superoxide dismutase, mitochondrial transcription, ATP production, complex I activity, neuronal injury, synaptic injury, neuroprotection
- MeSH terms
- Allyl Compounds, Animals, Biphenyl Compounds, Cognition, DNA, Mitochondrial, Fluorides, Humans, Mitochondria, Neuroblastoma, Phenols, Lignans, Oxidative Stress, RNA, Small Interfering, Mice, AMP-Activated Protein Kinases, Sirtuin 3, Cognitive Dysfunction
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