Mangiferin prevents the impairment of mitochondrial dynamics and an increase in oxidative stress caused by excessive fluoride in SH‐SY5Y cells

The role of oxidative stress in neurodegenerative diseases

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Mangiferin attenuates the symptoms of dextran sulfate sodium-induced colitis in mice via NF-κB and MAPK signaling inactivation

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Protective effects of mangiferin on cerebral ischemia-reperfusion injury and its mechanisms

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Influence of Chronic Fluorosis on Membrane Lipids in Rat Brain

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Mammalian Target of Rapamycin (mTor) Mediates Tau Protein Dyshomeostasis

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Antioxidant Defense System and Lipid Peroxidation in Patients with Skeletal Fluorosis and in Fluoride-Intoxicated Rabbits

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Nrf2/HO-1 mediates the neuroprotective effect of mangiferin on early brain injury after subarachnoid hemorrhage by attenuating mitochondria-related apoptosis and neuroinflammation

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Sodium fluoride induces nephrotoxicity via oxidative stress-regulated mitochondrial SIRT3 signaling pathway

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Medicinal Properties of Mangiferin, Structural Features, Derivative Synthesis, Pharmacokinetics and Biological Activities

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Fluoride induces apoptosis via inhibiting SIRT1 activity to activate mitochondrial p53 pathway in human neuroblastoma SH-SY5Y cells

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Mitochondrial Dynamics

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Roles of mitochondrial fission inhibition in developmental fluoride neurotoxicity: mechanisms of action in vitro and associations with cognition in rats and children

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The influence of chronic fluorosis on mitochondrial dynamics morphology and distribution in cortical neurons of the rat brain

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Increased level of apoptosis in rat brains and SH-SY5Y cells exposed to excessive fluoride—A mechanism connected with activating JNK phosphorylation

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Activation of the AGE/RAGE system in the brains of rats and in SH-SY5Y cells exposed to high level of fluoride might connect to oxidative stress

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Mangiferin ameliorates gestational diabetes mellitus-induced placental oxidative stress, inflammation and endoplasmic reticulum stress and improves fetal outcomes in mice

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Mangiferin Antagonizes Rotenone: Induced Apoptosis Through Attenuating Mitochondrial Dysfunction and Oxidative Stress in SK-N-SH Neuroblastoma Cells

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Determination of protein mobility in mitochondrial membranes of living cells

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Oxidative stress might be a mechanism connected with the decreased α7 nicotinic receptor influenced by high-concentration of fluoride in SH-SY5Y neuroblastoma cells

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Effects of long-term fluoride exposure on cognitive ability and the underlying mechanisms: Role of autophagy and its association with apoptosis

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Mangiferin induces apoptosis in human ovarian adenocarcinoma OVCAR3 cells via the regulation of Notch3

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Neuroprotection of mangiferin against oxidative damage via arousing Nrf2 signaling pathway in PC12 cells

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Mangiferin protects osteoblast against oxidative damage by modulation of ERK5/Nrf2 signaling

Xia, G., Li, X., Zhu, X., Yin, X., Ding, H., & Qiao, Y. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.06.184 · Cited by 35 · see citing works

Mechanism of anti-dementia effects of mangiferin in a senescence accelerated mouse (SAMP8) model

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Mangiferin ameliorates collateral neuropathy in t BHP induced apoptotic nephropathy by inflammation mediated kidney to brain crosstalk

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Pharmacological and biochemical studies on protective effects of mangiferin and its interaction with nitric oxide (NO) modulators in adjuvant-induced changes in arthritic parameters, inflammatory, and oxidative biomarkers in rats

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Apoptosis in the mammalian CNS: Lessons from animal models

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Modeling of thermal degradation kinetics of the C -glucosyl xanthone mangiferin in an aqueous model solution as a function of pH and temperature and protective effect of honeybush extract matrix

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Mangiferin ameliorates insulin resistance by inhibiting inflammation and regulatiing adipokine expression in adipocytes under hypoxic condition

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Developmental Fluoride Neurotoxicity: Clinical Importance versus Statistical Significance

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To the editor

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Effect of Fluoride on Cytotoxicity Involved in Mitochondrial Dysfunction: A Review of Mechanism

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Molecular basis of fluoride toxicities: Beyond benefits and implications in human disorders

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Role of oxidative stress-mediated cell death and signaling pathways in experimental fluorosis

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Mangiferin, a natural glucoxilxanthone, inhibits mitochondrial dynamin-related protein 1 and relieves aberrant mitophagic proteins in mice model of Parkinson's disease

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Plant Secondary Metabolites as Modulators of Mitochondrial Health: An Overview of Their Anti-Oxidant, Anti-Apoptotic, and Mitophagic Mechanisms

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Mitochondrial Modulators: The Defender

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Effects of fluoride exposure on mitochondrial function: Energy metabolism, dynamics, biogenesis and mitophagy

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Inhibition of Drp1-dependent mitochondrial fission by natural compounds as a therapeutic strategy for organ injuries

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Myricetin ameliorates cognitive impairment in 3×Tg Alzheimer's disease mice by regulating oxidative stress and tau hyperphosphorylation.

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Virtual screening and in vitro experimental verification of LuxS inhibitors from natural products for Lactobacillus reuteri

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Mangiferin, a Potential Supplement to Improve Metabolic Syndrome: Current Status and Future Opportunities

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Fluoride-Induced Mitochondrial Dysfunction and Approaches for Its Intervention

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Regulating effect of miR-132–3p on the changes of MAPK pathway in rat brains and SH-SY5Y cells exposed to excessive fluoride by targeting expression of MAPK1

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Echinacoside activates Nrf2/PPARγ signaling pathway to modulate mitochondrial fusion-fission balance to ameliorate ox-LDL-induced dysfunction of coronary artery endothelial cells

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A Review on Experimentally Proven Medicinal Plants and Their Constituents against Fluoride Toxicity

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Quercetin reduces APP expression, oxidative stress and mitochondrial dysfunction in the N2a/APPswe cells via ERK1/2 and AKT pathwaysPreprint

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Myricetin protected against Aβ oligomer-induced synaptic impairment, mitochondrial function and oxidative stress in SH-SY5Y cells via ERK1/2/GSK-3β pathwaysPreprint

Wang, L., Tang, Z., Deng, Y., Peng, Y., Xiao, Y. C., Xu, J., Ni, R., & Qi, X. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.12.523781 · Cited by 4 · see citing works

Mangiferin in human disease: Multifaceted mechanisms and applications (Review)

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Bioactive compounds from Crataegus pinnatifida Bge. leaves: potential health benefits

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Advances in Mangiferin: Biosynthetic Pathways, Bioavailability and Bioactivity

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Nuclear factor E2 related factor 2 may alleviate liver injury by regulating iron overload and lipid peroxidation induced by chronic fluorosis

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Impact of fluoride exposure at different concentrations on preosteoblastic cells: Molecular, biochemical, and morphological insights

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Amelioration of Fluoride Induced Toxicity by trans ‐Chalcone in Zebrafish Larvae and Its Gill Cell Line: An In Vivo and In Vitro Approach

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Emodin Suppresses Fluoride‐Induced Pyroptosis in SH‐SY5Y Cells Through the Inhibition of NLRP3 Inflammasome Activation

Lai, C., Jiang, T., Xu, T., Zhang, T., Zhou, Y., Deng, D., & Chen, Q. (2025) · Journal of Food Biochemistry · doi:10.1155/jfbc/9948159

Grape Seed Proanthocyanins Extract Ameliorates the Neurotoxicity Induced by Fluoride Through mTOR/p70s6k Signaling Pathway in Vivo and in Vitro

Zhao, W., Gong, Z., Wang, B., Wu, Z., Guo, Y., Wang, S., Zhai, H., Zheng, X., & Yang, L. (2025) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-025-01916-x

Fluoride exposure impairs lysosomal biogenesis and autophagic flux in myocardial injury: Involvement of the FNIP1/mTOR/TFEB pathway

Liao, W., Tu, X., Deng, J., Xiang, J., He, W.-W., Xiao, X., Zeng, X.-X., Dong, Y., Qi, X.-L., Xiao, Y., et al. (2026) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2026.120230

Fluoride exposure induces oxidative damage in primary astrocytes of SD rats and changes in the expression of α-synuclein and its effect on Nrf2-NQO1/HO-1 signaling pathway

Zhou, X., Mo, K., Wan, W., Ye, L., Liu, M., Guan, Z., Ding, Y., Liu, Y., & Xu, S. (2026) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-026-10128-8

Mangiferin Ameliorates Glutamate‐Induced Excitatory Toxicity in SH‐SY5Y Cells via Nrf2/HO‐1 and Apoptosis Pathway

Zhou, R., Gao, Y., Shang, B., He, J., Fang, M., & Cao, Y. (2026) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70748 · Cited by 1 · see citing works

Naringin alleviates fluoride-induced neurological impairment: A focus on the regulation of energy metabolism mediated by mitochondrial permeability transition pore

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Roles of mitochondrial fission inhibition in developmental fluoride neurotoxicity: mechanisms of action in vitro and associations with cognition in rats and children

Zhao, Q., Niu, Q., Chen, J., Xia, T., Zhou, G.-Y., Li, P.-Y., Dong, L., Xu, C., Tian, Z.-Y., Luo, C., et al. (2019) · Archives of Toxicology · doi:10.1007/s00204-019-02390-0 · Cited by 60 · see citing works

SIRT1, a target of miR-708-3p, alleviates fluoride-induced neuronal damage via remodeling mitochondrial network dynamics

Zhao, Q., Zhou, G., Niu, Q., Chen, J., Li, P., Tian, Z., Li, D., Xia, T., Zhang, S., & Wang, A. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.11.032 · Cited by 19 · see citing works

Anti-Oxidative Effect of Genistein and Mangiferin on Sodium Fluoride Induced Oxidative Insult of Renal Cells: A Comparative Study

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