Cited by 65Health Systems, Economic Evaluations, Quality of LifeEconomic and Environmental ValuationPharmaceutical Economics and Policy

Econometric modelling of multiple self-reports of health states: the switch from EQ-5D-3L to EQ-5D-5L in evaluating drug therapies for rheumatoid arthritis

Open access
Hernández-Alava, Mónica, Pudney, Stephen·2017·Journal of Health Economics

Abstract

EQ-5D is used in cost-effectiveness studies underlying many important health policy decisions. It comprises a survey instrument describing health states across five domains, and a system of utility values for each state. The original 3-level version of EQ-5D is being replaced with a more sensitive 5-level version but the consequences of this change are uncertain. We develop a multi-equation ordinal response model incorporating a copula specification with normal mixture marginals to analyse joint responses to EQ-5D-3L and EQ-5D-5L in a survey of people with rheumatic disease, and use it to generate mappings between the alternative descriptive systems. We revisit a major cost-effectiveness study of drug therapies for rheumatoid arthritis, mapping the original EQ-5D-3L measure onto a 5L valuation basis. Working within a comprehensive, flexible econometric framework, we find that use of simpler restricted specifications can make very large changes to cost-effectiveness estimates with serious implications for decision-making.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.jhealeco.2017.06.013

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 34 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

  1. Longworth L. Rowen D. The use of mapping methods to estimate health state utility values Technical Report NICE DSU Technical Support Document 10, Decision Support Unit 2011 Health Economics & Decision Science, University of Sheffield 28481491
  2. NICE Guide to the methods of technology appraisal 2013. Technical report 2013 National Institute for Health and Care Excellence 27905712

Cited by

Sorted by citations

Authors
Hernández-Alava, M., & Pudney, S.
Affiliations
University of Sheffield (GB)
Corresponding author
Pudney, Stephen
Venue
Journal of Health Economics
Publisher
Elsevier BV
Published
2017-09
Volume
55
Pages
139-152
ISSN
0167-6296 (ISSN-L)
OpenAlex
W2731622813
Cited by
64
References
34
Citations by year
2026: 5 · 2025: 8 · 2024: 5 · 2023: 6 · 2022: 13 · 2021: 9 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 1
FWCI
9.35
Type
journal article
Language
en
Open access
Locations
  • Journal of Health Economics (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Funders
  • University of Nebraska Medical Center
  • Medical Research Council (MR/L022575/1)
  • Economic and Social Research Council (ES/K005146/1, ES/L009153/1, ES/H00811X/1)
Topics
  • Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
  • Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Economic and Environmental Valuation
  • Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Pharmaceutical Economics and Policy
Keywords
EQ-5D-3L, EQ-5D-5L, health state valuation, utility mapping, copulas, rheumatoid arthritis, health-related quality of life
MeSH terms
Arthritis, Rheumatoid, Cost-Benefit Analysis, Female, Health Status, Humans, Male, Quality of Life, Treatment Outcome, Models, Econometric, Antirheumatic Agents, Self Report

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review