The murine liver is a potential target organ for IL-19, IL-20 and IL-24: type I Interferons and LPS regulate the expression of IL-20R2
Abstract
Background/aims The biological functions of the recently discovered IL-10-related cytokines IL-19, IL-20, IL-22, IL-24 and their receptors IL-20R1, IL-20R2 and IL-22R are not clear. Therefore, the expression of these cytokines and their receptors in the hepatic acute phase response to LPS was analysed. Type I interferons have important immunomodulatory functions in bacterial infections. We investigated if they influence release and organ-specific expression of TNF, IL-6 and IL-10 and the responsiveness of liver to IL-10 related cytokines during the reaction to LPS in vivo. Methods B6 and congenic IFNAR-/- mice were intraperitoneally injected with 5mg/kg LPS. Systemic release of cytokines was quantified by ELISA. Organ-specific expression of cytokines and their receptors was evaluated by (semi quantitative or quantitative) RT-PCR. Results The cytokines IL-19, IL-22 and the IL-20R2 receptor subunit are up-regulated by LPS in the liver of normal mice. IFNalpha/beta enhance the secretion and expression of IL-6 and IL-10 during the response to LPS, but also the up-regulation of IL-20R2 expression. Conclusions We show that the liver is a potential target for IL-19, IL-20 and IL-24. During an LPS response, IFNalpha/beta influence cytokine secretion and expression and possibly the response to IL-19 and IL-24.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Others observed a peak of Il22 mRNA induction in liver at ~3 h post hepatectomy or 4 h after LPS injection, later than the rapid maximal STAT3 phosphorylation observed in this study.
“Others observed a peak of Il22 mRNA induction in the liver at ~3 h post hepatectomy (Rao et al., 2014) or 4 h after LPS injection (Wegenka et al., 2007) and thus much later than the rapid maximal phosphorylation of STAT3 we observed in our study in the liver of hepatectomized or LPS treated mice.”
From Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib (2017) · cites this paper as Wegenka et al., 2007
Cites
Dumoutier, L., Leemans, C., Lejeune, D., Kotenko, S. V., & Renauld, J.-C. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.7.3545 · Cited by 405 · see citing works
Klein, C., Wüstefeld, T., Assmus, U., Roskams, T., Rose-John, S., Müller, M., Manns, M. P., Ernst, M., & Trautwein, C. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200523640 · Cited by 200 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Sobotta, S., Raue, A., Huang, X., Vanlier, J., Jünger, A., Bohl, S., Albrecht, U., Hahnel, M. J., Wolf, S., Mueller, N. S., et al. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00775 · Cited by 28 · see citing works
“Further, in response to LPS injection a very low level of induction of Il22 mRNA was observed in the liver with a peak at 4 h post injection, whereas a much stronger activation of Il22 mRNA with comparable kinetics was observed in the spleen (Wegenka et al., 2007).”
Background
- Authors
- Wegenka, U. M., Dikopoulos, N., Reimann, J., Adler, G., & Wahl, C.
- Affiliations
- Universität Ulm (DE)
- Corresponding author
- Wegenka, Ursula Maria
- ORCID
- Reimann, Jörg
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2007-02
- Volume
- 46
- Issue
- 2
- Pages
- 257-265
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W2022121957
- Cited by
- 30
- References
- 2
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 2 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 1 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- IL-19, IL-20, IL-24, IL-22, type I interferon, lipopolysaccharide, liver, cytokine expression, interleukin-6, IL-10, TNF-α, IFNAR-deficient mice
- MeSH terms
- Interleukin-24, Acute-Phase Proteins, Animals, Interferon Type I, Interleukins, Lipopolysaccharides, Liver, Mice, Mutant Strains, RNA, Messenger, Spleen, Transcription, Genetic, Up-Regulation, Cytokines, Interleukin-10, Receptors, Interleukin, STAT3 Transcription Factor, Mice, Receptor, Interferon alpha-beta
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
