Cutting Edge: STAT Activation By IL-19, IL-20 and mda-7 Through IL-20 Receptor Complexes of Two Types
Open accessAbstract
IL-10-related cytokines include IL-20 and IL-22, which induce, respectively, keratinocyte proliferation and acute phase production by hepatocytes, as well as IL-19, melanoma differentiation-associated gene 7, and AK155, three cytokines for which no activity nor receptor complex has been described thus far. Here, we show that mda-7 and IL-19 bind to the previously described IL-20R complex, composed by cytokine receptor family 2–8/IL-20Rα and DIRS1/IL-20Rβ (type I IL-20R). In addition, mda-7 and IL-20, but not IL-19, bind to another receptor complex, composed by IL-22R and DIRS1/IL20Rβ (type II IL-20R). In both cases, binding of the ligands results in STAT3 phosphorylation and activation of a minimal promoter including STAT-binding sites. Taken together, these results demonstrate that: 1) IL-20 induces STAT activation through IL-20R complexes of two types; 2) mda-7 and IL-20 redundantly signal through both complexes; and 3) IL-19 signals only through the type I IL-20R complex.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
IL-22 mediates its functions by binding to its heterodimeric receptor consisting of IL-10 receptor β2 (IL-10Rβ2) and IL-22 receptor (IL-22R) and activating signaling pathways that stimulate STAT3 phosphorylation and nuclear translocation.
“IL-22 mediates its functions by binding to its heterodimeric receptor consisting of IL-10 receptor β2 (IL-10Rβ2) and IL-22 receptor (IL-22R) and activating signaling pathways, which stimulate STAT3 phosphorylation and nuclear translocation.80–84”
From The Innate Immune System in Acute and Chronic Wounds (2016) · cites this paper as [80]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Interleukin-10 and the Interleukin-10 Receptor
Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O'Garra, A. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.683 · Cited by 6,737 · see citing works
Blumberg, H., Conklin, D., Xu, W., Grossmann, A., Brender, T., Carollo, S., Eagan, M., Foster, D., Haldeman, B. A., Hammond, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00187-8 · Cited by 542 · see citing works
Xie, M.-H., Aggarwal, S., Ho, W.-H., Foster, J., Zhang, Z., Stinson, J., Wood, W. I., Goddard, A. D., & Gurney, A. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005304200 · Cited by 541 · see citing works
Dumoutier, L., Louahed, J., & Renauld, J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.4.1814 · Cited by 500 · see citing works
Self-citationJiang, H., Lin, J. J., Su, Z.-Z., Goldstein, N. I., & Fisher, P. B. (1995) · PubMed · Cited by 486 · see citing works
Identification of the Functional Interleukin-22 (IL-22) Receptor Complex
Kotenko, S. V., Izotova, L. S., Mirochnitchenko, O. V., Esterova, E., Dickensheets, H. L., Donnelly, R. P., & Pestka, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007837200 · Cited by 400 · see citing works
Self-citationDumoutier, L., Roost, E. V., Colau, D., & Renauld, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.170291697 · Cited by 365 · see citing works
Self-citationGallagher, G. E., Dickensheets, H. L., Eskdale, J., Ls, I., Mirochnitchenko, O., Peat, J. E., Vazquez, N., Pestka, S., Donnelly, R. P., & Kotenko, S. V. (2000) · Genes and Immunity · doi:10.1038/sj.gene.6363714 · Cited by 288 · see citing works
Self-citationThe melanoma differentiation associated gene mda-7 suppresses cancer cell growth.
Jiang, H., Su, Z. Z., Lin, J. J., Goldstein, N. I., Young, C. S., & Fisher, P. B. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.17.9160 · Cited by 278 · see citing works
Kotenko, S. V., Izotova, L. S., Mirochnitchenko, O. V., Esterova, E., Dickensheets, H., Donnelly, R. P., & Pestka, S. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7096 · Cited by 260 · see citing works
Self-citationSu, Z.-Z., Madireddi, M. T., Lin, J. J., Young, C. S. H., Kitada, S., Reed, J. C., Goldstein, N. I., & Fisher, P. B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14400 · Cited by 254 · see citing works
Dumoutier, L., Lejeune, D., Colau, D., & Renauld, J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7090 · Cited by 251 · see citing works
Self-citationKnappe, A., Hör, S., Wittmann, S., & Fickenscher, H. (2000) · Journal of Virology · doi:10.1128/jvi.74.8.3881-3887.2000 · Cited by 214 · see citing works
Demoulin, J., Uyttenhove, C., Roost, E. V., de Lestré, B., Donckers, D., Snick, J. V., & Renauld, J. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4710 · Cited by 181 · see citing works
Self-citationSchaefer, G., Venkataraman, C., & Schindler, U. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.10.5859 · Cited by 84 · see citing works
Soo, C. B., Shaw, W. W.-L., FREYMILLER, E. G., Longaker, M. T., Bertolami, C. N., Chiu, R., Tieu, A., & Kang, T. (1999) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19990701)74:1 · Cited by 78 · see citing works
Identification of a Novel Ligand-Receptor Pair Constitutively Activated by ras Oncogenes
Zhang, R., Tan, Z., & Liang, P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001958200 · Cited by 57 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Dumoutier, L., E. Van Roost, D. Colau, and J.-C. Renauld. 2000. Human IL-TIF: molecular cloning and functional characterization as an hepatocyte stimulating factor. Proc. Natl. Acad. Sci. USA 97:10144.
Cited by
Sorted by citations
Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease
Ouyang, W., Rutz, S., Crellin, N. K., Valdez, P. A., & Hymowitz, S. G. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101312 · Cited by 1,932 · see citing works
The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation
Ouyang, W., Kolls, J. K., & Zheng, Y. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.004 · Cited by 1,698 · see citing works
I nterleukin -10 and R elated C ytokines and R eceptors
Pestka, S., Krause, C. D., Sarkar, D., Walter, M. R., Shi, Y., & Fisher, P. B. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104622 · Cited by 1,097 · see citing works
IL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation
Ouyang, W., & O’Garra, A. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.020 · Cited by 1,084 · see citing works
Interleukin-10 Therapy—Review of a New Approach
Asadullah, K., Sterry, W., & Volk, H. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.2.4 · Cited by 941 · see citing works
Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease
Zenewicz, L. A., Yancopoulos, G. D., Valenzuela, D. M., Murphy, A. J., Stevens, S. G., & Flavell, R. A. (2008) · Immunity · doi:10.1016/j.immuni.2008.11.003 · Cited by 797 · see citing works
Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in diseases
Akdiş, M., Bürgler, S., Crameri, R., Eiwegger, T., Fujita, H., Alcaide, E. G., Klunker, S., Meyer, N., O’Mahony, L., Palomares, Ó., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.11.050 · Cited by 780 · see citing works
Cutting Edge: Immune Cells as Sources and Targets of the IL-10 Family Members?
Wolk, K., Kunz, S., Asadullah, K., & Sabat, R. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5397 · Cited by 581 · see citing works
Therapeutic opportunities of the IL-22–IL-22R1 system
Sabat, R., Ouyang, W., & Wolk, K. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4176 · Cited by 559 · see citing works
Susan, M. L., Valdez, P. A., Wu, J., Jung, K., Zhong, F., Hall, L., Kasman, I. M., Winer, J., Modrusan, Z. D., Danilenko, D. M., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.4.2229 · Cited by 509 · see citing works
Lejeune, D., Dumoutier, L., Constantinescu, S. N., Kruijer, W., Schuringa, J. J., & Renauld, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204204200 · Cited by 478 · see citing works
Self-citationWolk, K., Haugen, H. S., Xu, W., Witte, E., Waggie, K. S., Anderson, M., Baur, E. V., Witte, K., Warszawska, K., Philipp, S., et al. (2009) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0457-0 · Cited by 410 · see citing works
Wolk, K., Witte, E., Witte, K., Warszawska, K., & Sabat, R. (2010) · Seminars in Immunopathology · doi:10.1007/s00281-009-0188-x · Cited by 395 · see citing works
Cytokine and Cytokine Receptor Pleiotropy and Redundancy
Ozaki, K., & Leonard, W. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r200003200 · Cited by 344 · see citing works
The interleukin-10 family of cytokines
Fickenscher, H., Hör, S., Küpers, H., Knappe, A., Wittmann, S., & Sticht, H. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(01)02149-4 · Cited by 329 · see citing works
IL-19 Induces Production of IL-6 and TNF-α and Results in Cell Apoptosis Through TNF-α
Liao, Y.-C., Liang, W. F., Chen, F., Hsu, J.-H., Yang, J., & Chang, M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.8.4288 · Cited by 329 · see citing works
Interrelation of immunity and tissue repair or regeneration
Eming, S. A., Hammerschmidt, M., Krieg, T., & Roers, A. (2009) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2009.04.009 · Cited by 321 · see citing works
Interleukin-22: A novel T- and NK-cell derived cytokine that regulates the biology of tissue cells
Wolk, K., & Sabat, R. (2006) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2006.09.001 · Cited by 303 · see citing works
Sarkar, D., Su, Z.-Z., Lebedeva, I. V., Sauane, M., Gopalkrishnan, R. V., Valerie, K. C., Dent, P., & Fisher, P. B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152327199 · Cited by 301 · see citing works
Sabat, R. (2010) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2010.11.001 · Cited by 297 · see citing works
The Innate Immune System in Acute and Chronic Wounds
MacLeod, A. S., & Mansbridge, J. N. (2016) · Advances in Wound Care · doi:10.1089/wound.2014.0608 · Cited by 289 · see citing works
The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain
Donnelly, R. P., Sheikh, F., Kotenko, S. V., & Dickensheets, H. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0204117 · Cited by 289 · see citing works
Self-citationInterleukins 19, 20, and 24 Signal through Two Distinct Receptor Complexes
Parrish-Novak, J. E., Xu, W., Brender, T., Yao, L. Y., Jones, C. A., West, J., Brandt, C. S., Jelinek, L., Madden, K., McKernan, P. A., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205114200 · Cited by 268 · see citing works
Class II cytokine receptors and their ligands: Key antiviral and inflammatory modulators
Renauld, J. (2003) · Nature reviews. Immunology · doi:10.1038/nri1153 · Cited by 265 · see citing works
Self-citationCaudell, E. G., Mumm, J. B., Poindexter, N. J., Ekmekçioglu, S., Mhashilkar, A. M., Yang, X. H., Retter, M. W., Hill, P. A., Chada, S., & Grimm, E. A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.12.6041 · Cited by 258 · see citing works
Kunz, S., Wolk, K., Witte, E., Witte, K., Doecke, W., Volk, H., Sterry, W., Asadullah, K., & Sabat, R. (2006) · Experimental Dermatology · doi:10.1111/j.1600-0625.2006.00516.x · Cited by 237 · see citing works
Witte, E., Witte, K., Warszawska, K., Sabat, R., & Wolk, K. (2010) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2010.08.002 · Cited by 232 · see citing works
The family of IL-10-related cytokines and their receptors: related, but to what extent?
Kotenko, S. V. (2002) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(02)00012-6 · Cited by 213 · see citing works
Self-citationHuman interferon lambda-1 (IFN-λ1/IL-29) modulates the Th1/Th2 response
Jordan, W. J., Eskdale, J., Srinivas, S., Pekarek, V., Kelner, D., Rodia, M. T., & Gallagher, G. E. (2007) · Genes and Immunity · doi:10.1038/sj.gene.6364382 · Cited by 208 · see citing works
The Interleukin-10 Family of Cytokines and Their Role in the CNS
Burmeister, A. R., & Marriott, I. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00458 · Cited by 208 · see citing works
Alti, D., Chandrasekaran, S., Kuchipudi, S. V., & Kalangi, S. K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00670 · Cited by 207 · see citing works
Montecucco, F., & Mach, F. (2008) · Rheumatology · doi:10.1093/rheumatology/ken395 · Cited by 203 · see citing works
The cancer growth suppressing gene mda-7 induces apoptosis selectively in human melanoma cells
Lebedeva, I. V., Su, Z.-Z., Chang, Y., Kitada, S., Reed, J. C., & Fisher, P. B. (2002) · Oncogene · doi:10.1038/sj.onc.1205116 · Cited by 203 · see citing works
Is mda-7/IL-24 a “Magic Bullet” for Cancer?
Fisher, P. B. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-3127 · Cited by 201 · see citing works
The Class II cytokine receptor (CRF2) family: overview and patterns of receptor–ligand interactions
Langer, J. A., Cutrone, E. C., & Kotenko, S. V. (2004) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2003.10.001 · Cited by 193 · see citing works
Self-citationChong, W. P., Mattapallil, M. J., Raychaudhuri, K., Bing, S. J., Wu, S., Zhong, Y., Wang, W., Chen, Z., Silver, P. B., Jittayasothorn, Y., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.06.022 · Cited by 183 · see citing works
Human mast cells are major IL-22 producers in patients with psoriasis and atopic dermatitis
Mashiko, S., Bouguermouh, S., Rubio, M., Baba, N., Bissonnette, R., & Sarfati, M. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.01.033 · Cited by 180 · see citing works
Wolk, K., Witte, E., Warszawska, K., Schulze-Tanzil, G. G., Witte, K., Philipp, S., Kunz, S., Döcke, W., Asadullah, K., Volk, H., et al. (2009) · European Journal of Immunology · doi:10.1002/eji.200939687 · Cited by 179 · see citing works
mda-7/IL-24: Multifunctional cancer-specific apoptosis-inducing cytokine
Gupta, P., Su, Z. Z., Lebedeva, I. V., Sarkar, D., Sauane, M., Emdad, L., Bachelor, M. A., Grant, S., Curiel, D. T., & Dent, P. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.11.005 · Cited by 179 · see citing works
Ramesh, R., Mhashilkar, A. M., Tanaka, F., Saito, Y., Branch, C. D., Sieger, K., Mumm, J. B., Stewart, A. L., Boquoi, A., Dumoutier, L., et al. (2003) · PubMed · Cited by 178 · see citing works
Self-citationStructure of IL-22 Bound to Its High-Affinity IL-22R1 Chain
Jones, B. C., Logsdon, N. J., & Walter, M. R. (2008) · Structure · doi:10.1016/j.str.2008.06.005 · Cited by 176 · see citing works
Sheikh, F. G., Baurin, V. V., Lewis-Antes, A., Shah, N. K., Sv, S., Anantha, S., Dickensheets, H. L., Dumoutier, L., Renauld, J., Zdanov, A. S., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.4.2006 · Cited by 173 · see citing works
Self-citationKumari, S., Bonnet, M., Ulvmar, M. H., Wolk, K., Karagianni, N., Witte, E., Uthoff‐Hachenberg, C., Renauld, J., Kollias, G. A., Toftgård, R., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.10.009 · Cited by 170 · see citing works
Self-citationHofmann, S. R., Rösen‐Wolff, A., Tsokos, G. C., & Hedrich, C. M. (2012) · Clinical Immunology · doi:10.1016/j.clim.2012.02.005 · Cited by 169 · see citing works
Su, Z.-Z., Lebedeva, I. V., Sarkar, D., Gopalkrishnan, R. V., Sauane, M., Sigmon, C., Yacoub, A., Valerie, K. C., Dent, P., & Fisher, P. B. (2003) · Oncogene · doi:10.1038/sj.onc.1206062 · Cited by 168 · see citing works
IL-28A, IL-28B, and IL-29: Promising cytokines with type I interferon-like properties
Witte, K., Witte, E., Sabat, R., & Wolk, K. (2010) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2010.04.002 · Cited by 167 · see citing works
Steiniche, T., Kragballe, K., Rømer, J., Hasselager, E., Nørby, P. L., & Clausen, J. T. (2003) · Journal of Investigative Dermatology · doi:10.1111/j.1523-1747.2003.12626.x · Cited by 166 · see citing works
IL-19 Is a Component of the Pathogenetic IL-23/IL-17 Cascade in Psoriasis
Witte, E., Kokolakis, G., Witte, K., Philipp, S., Doecke, W., Babel, N., Wittig, B. M., Warszawska, K., Kurek, A., Erdmann‐Keding, M., et al. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.308 · Cited by 165 · see citing works
The role of the IL-22/IL-22R1 axis in cancer
Lim, C., & Savan, R. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.04.005 · Cited by 162 · see citing works
IL-22 promotes fibroblast-mediated wound repair in the skin
McGee, H. M., Schmidt, B. A., Booth, C. J., Yancopoulos, G. D., Valenzuela, D. M., Murphy, A. J., Stevens, S., Flavell, R. A., & Horsley, V. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.463 · Cited by 161 · see citing works
Andoh, A., Shioya, M., Nishida, A., Bamba, S., Tsujikawa, T., Kim‐Mitsuyama, S., & Fujiyama, Y. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804169 · Cited by 156 · see citing works
MDA-7/IL-24: novel cancer growth suppressing and apoptosis inducing cytokine
Sauane, M., Gopalkrishnan, R. V., Sarkar, D., Su, Z.-Z., Lebedeva, I. V., Dent, P., Pestka, S., & Fisher, P. B. (2002) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(02)00074-6 · Cited by 155 · see citing works
Kanduri, M., Cahill, N., Göransson, H., Enström, C., Ryan, F., Isaksson, A., & Rosenquist, R. (2009) · Blood · doi:10.1182/blood-2009-07-232868 · Cited by 146 · see citing works
Function of interleukin‐20 as a proinflammatory molecule in rheumatoid and experimental arthritis
Hsu, Y., Li, H. H., Hsieh, M., Liu, M.-F., Huang, K., Chin, L.-S., Chen, P., Cheng, H., & Chang, M. (2006) · Arthritis & Rheumatism · doi:10.1002/art.22039 · Cited by 145 · see citing works
Su, Z.-Z., Emdad, L., Sauane, M., Lebedeva, I. V., Sarkar, D., Gupta, P., James, C. D., Randolph, A. L., Valerie, K. C., Walter, M. R., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1208911 · Cited by 145 · see citing works
Hör, S., Pirzer, H., Dumoutier, L., Bauer, F., Wittmann, S., Sticht, H., Renauld, J., Malefyt, R. D. W., & Fickenscher, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405000200 · Cited by 144 · see citing works
Self-citationOral, H. B., Kotenko, S. V., Yılmaz, M., Mani, O., Zumkehr, J., Blaser, K., Akdiş, C. A., & Akdiş, M. (2005) · European Journal of Immunology · doi:10.1002/eji.200425523 · Cited by 141 · see citing works
Self-citationNagalakshmi, M. L., Murphy, E., McClanahan, T. K., & Malefyt, R. D. W. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.01.007 · Cited by 139 · see citing works
Evolution of the Class 2 cytokines and receptors, and discovery of new friends and relatives
Krause, C. D., & Pestka, S. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.12.002 · Cited by 136 · see citing works
Laminin-411 Is a Vascular Ligand for MCAM and Facilitates TH17 Cell Entry into the CNS
Flanagan, K., Fitzgerald, K., Baker, J., Regnstrom, K., Gardai, S., Bard, F., Mocci, S., Seto, P., You, M., Larochelle, C., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040443 · Cited by 134 · see citing works
Human interleukin-19 and its receptor: a potential role in the induction of Th2 responses
Gallagher, G. E., Eskdale, J., Jordan, W., Peat, J. E., Campbell, J. D. M., Boniotto, M., Lennon, G. P., Dickensheets, H. L., & Donnelly, R. P. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.01.005 · Cited by 134 · see citing works
Interleukin-26: An IL-10-related cytokine produced by Th17 cells
Donnelly, R. P., Sheikh, F. G., Dickensheets, H. L., Savan, R., Young, H. A., & Walter, M. R. (2010) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2010.09.001 · Cited by 132 · see citing works
DUMOUTIER, L., LEJEUNE, D., HOR, S., FICKENSCHER, H., & RENAULD, J.-C. (2003) · Biochemical Journal · doi:10.1042/bj20021935 · Cited by 128 · see citing works
Self-citationPataer, A., Vorburger, S. A., Barber, G. N., Chada, S., Mhashilkar, A. M., Zou-Yang, H., Stewart, A. L., Balachandran, S., Roth, J. A., Hunt, K. K., et al. (2002) · PubMed · Cited by 127 · see citing works
IL-22, a Th1 cytokine that targets the pancreas and select other peripheral tissues
Gurney, A. L. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.01.016 · Cited by 120 · see citing works
Autocrine regulation of mda -7/IL-24 mediates cancer-specific apoptosis
Sauane, M., Su, Z.-Z., Gupta, P., Lebedeva, I. V., Dent, P., Sarkar, D., & Fisher, P. B. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804089105 · Cited by 120 · see citing works
Interleukin-19 protects mice from innate-mediated colonic inflammation
Azuma, Y., Matsuo, Y., Kuwamura, M., Yancopoulos, G. D., Valenzuela, D. M., Murphy, A. J., Nakajima, H., Karow, M. L., & Takeuchi, T. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21151 · Cited by 120 · see citing works
BiP/GRP78 Is an Intracellular Target for MDA-7/IL-24 Induction of Cancer-Specific Apoptosis
Gupta, P., Walter, M. R., Su, Z.-Z., Lebedeva, I. V., Emdad, L., Randolph, A. L., Valerie, K. C., Sarkar, D., & Fisher, P. B. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0577 · Cited by 119 · see citing works
MDA-7/IL-24: Multifunctional Cancer Killing Cytokine
Menezes, M. E., Bhatia, S., Bhoopathi, P., Das, S. K., Emdad, L., Dasgupta, S., Dent, P., Wang, X., Sarkar, D., & Fisher, P. B. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4471-6458-6_6 · Cited by 118 · see citing works
Kragstrup, T. W., Otkjær, K., Holm, C. K., Jørgensen, A., Hokland, M., Iversen, L., & Deleuran, B. W. (2007) · Cytokine · doi:10.1016/j.cyto.2007.10.004 · Cited by 117 · see citing works
The Biology and Functions of Th22 Cells
Jia, L., & Wu, C. Y. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-94-017-9487-9_8 · Cited by 116 · see citing works
A catch‐22: Interleukin‐22 and cancer
Hernández, P. P., Gronke, K., & Diefenbach, A. (2017) · European Journal of Immunology · doi:10.1002/eji.201747183 · Cited by 112 · see citing works
Interleukin-20 promotes angiogenesis in a direct and indirect manner
Hsieh, M., Chen, W.-Y., Jiang, M.-J., Cheng, B.-C., Huang, T.-Y., & Chang, M.-S. (2006) · Genes and Immunity · doi:10.1038/sj.gene.6364291 · Cited by 111 · see citing works
Otkjær, K., Kragballe, K., Funding, A. T., Clausen, J. T., Nørby, P. L., Steiniche, T., & Iversen, L. (2005) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2005.06800.x · Cited by 111 · see citing works
Massey, H. D., & McPherson, R. A. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0974-2.00047-6 · Cited by 111 · see citing works
Detection of IL-20 and its receptors on psoriatic skin
Wei, C.-C., Chen, W., Wang, Y.-C., Chen, P., Lee, J. Y., Wong, T., Chen, W. C., Wu, J.-C., Chen, G.-Y., Chang, M., et al. (2005) · Clinical Immunology · doi:10.1016/j.clim.2005.06.012 · Cited by 109 · see citing works
IL-19 and IL-20: two novel cytokines with importance in inflammatory diseases
Sabat, R., Wallace, E., Endesfelder, S., & Wolk, K. (2007) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.11.5.601 · Cited by 108 · see citing works
Is there an interaction between interleukin-10 and interleukin-22?
Wolk, K., Witte, E., Reineke, U., Witte, K., Friedrich, M., Sterry, W., Asadullah, K., Volk, H., & Sabat, R. (2004) · Genes and Immunity · doi:10.1038/sj.gene.6364144 · Cited by 106 · see citing works
mda-7/IL-24: Exploiting Cancer's Achilles' Heel
Lebedeva, I. V., Sauane, M., Gopalkrishnan, R. V., Sarkar, D., Su, Z.-Z., Gupta, P., Nemunaitis, J. J., Cunningham, C. C., Yacoub, A., Dent, P., et al. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.08.012 · Cited by 106 · see citing works
Chada, S., Mhashilkar, A. M., Ramesh, R., Mumm, J. B., Sutton, R. B., Bocangel, D., Zheng, M., Grimm, E. A., & Ekmekçioglu, S. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.08.020 · Cited by 105 · see citing works
Tohyama, M., Hanakawa, Y., Shirakata, Y., Dai, X., Yang, L., Hirakawa, S., Tokumaru, S., Okazaki, H., Sayama, K., & Hashimoto, K. (2009) · European Journal of Immunology · doi:10.1002/eji.200939473 · Cited by 103 · see citing works
Interleukin‐24 and its receptors
Wang, M., & Liang, P. (2005) · Immunology · doi:10.1111/j.1365-2567.2005.02094.x · Cited by 103 · see citing works
Interleukin-10 Family Cytokines Immunobiology and Structure
Wei, H.-X., Li, B., Sun, A., & Guo, F. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-9367-9_4 · Cited by 102 · see citing works
Wang, F., Lee, E., Lowes, M. A., Haider, A. S., Fuentes‐Duculan, J., Abello, M. V., Chamian, F. N., Cardinale, I. R., & Krueger, J. G. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700310 · Cited by 101 · see citing works
Nishikawa, T., Ramesh, R., Munshi, A., Chada, S., & Meyn, R. E. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.03.014 · Cited by 100 · see citing works
Comparison of Interleukin-22 and Interleukin-10 Soluble Receptor Complexes
Logsdon, N. J., Jones, B. C., Josephson, K., Cook, J., & Walter, M. R. (2002) · Journal of Interferon & Cytokine Research · doi:10.1089/10799900260442520 · Cited by 99 · see citing works
Srinivas, S., Dai, J., Eskdale, J., Gallagher, G. E., Megjugorac, N. J., & Gallagher, G. E. (2008) · Immunology · doi:10.1111/j.1365-2567.2008.02862.x · Cited by 98 · see citing works
Mda‐7/IL‐24 induces apoptosis of diverse cancer cell lines through JAK/STAT‐independent pathways
Sauane, M., Gopalkrishnan, R. V., Lebedeva, I. V., Mei, M. X., Sarkar, D., Su, Z.-Z., Kang, D., Dent, P., Pestka, S., & Fisher, P. B. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10309 · Cited by 98 · see citing works
STAT3-Activating Cytokines: A Therapeutic Opportunity for Inflammatory Bowel Disease?
Nguyen, P. M., Putoczki, T. L., & Ernst, M. (2015) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2014.0225 · Cited by 97 · see citing works
Regulation of apoptosis by type III interferons
Li, W., Lewis-Antes, A., Huang, J., Balan, M., & Kotenko, S. V. (2008) · Cell Proliferation · doi:10.1111/j.1365-2184.2008.00558.x · Cited by 97 · see citing works
Self-citationEmdad, L., Bhoopathi, P., Talukdar, S., Pradhan, A. K., Sarkar, D., Wang, X., Das, S. K., & Fisher, P. B. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.07.013 · Cited by 96 · see citing works
Interleukin-19 upregulates keratinocyte growth factor and is associated with psoriasis
Li, H.-H., Lin, Y.-C., Chen, P.-J., Hsiao, C.-H., Lee, J. Y., Chen, W.-C., Tzung, T. Y., Wu, J.-C., & Chang, M. (2005) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2005.06665.x · Cited by 96 · see citing works
Bleicher, L., de Moura, P. R., Watanabe, L., Colau, D., Dumoutier, L., Renauld, J., & Polikarpov, I. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.07.046 · Cited by 94 · see citing works
Self-citationIL-10 subfamily members: IL-19, IL-20, IL-22, IL-24 and IL-26
Conti, P., Kempuraj, D., Frydas, S., Kandere‐Grzybowska, K., Boucher, W. S., Létourneau, R., Madhappan, B., Sagimoto, K., Christodoulou, S., & Theoharides, T. C. (2003) · Immunology Letters · doi:10.1016/s0165-2478(03)00087-7 · Cited by 93 · see citing works
Full house: 12 receptors for 27 cytokines
Kotenko, S. V., & Langer, J. A. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.01.003 · Cited by 93 · see citing works
Self-citationStructure and Mechanism of Receptor Sharing by the IL-10R2 Common Chain
Yoon, S., Jones, B. C., Logsdon, N. J., Harris, B. D., Deshpande, A. A., Radaeva, S., Halloran, B., Gao, B., & Walter, M. R. (2010) · Structure · doi:10.1016/j.str.2010.02.009 · Cited by 92 · see citing works
Fisher, P. B., Nemunaitis, J. J., Senzer, N. N., Dent, P., Grant, S., Yacoub, A., Curiel, D. T., Dmitriev, I. P., Mahasreshti, P. J., Pass, A. D., et al. (2007) · International Journal of Oncology · doi:10.3892/ijo.31.5.985 · Cited by 92 · see citing works
Chen, W., Cheng, B., Jiang, M. J., Hsieh, M., & Chang, M. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000232502.88144.6f · Cited by 92 · see citing works
Human IL‐19 regulates immunity through auto‐induction of IL‐19 and production of IL‐10
Jordan, W. J., Eskdale, J., Boniotto, M., Lennon, G. P., Peat, J. E., Campbell, J. D. M., & Gallagher, G. E. (2005) · European Journal of Immunology · doi:10.1002/eji.200425317 · Cited by 91 · see citing works
Logsdon, N. J., Deshpande, A. A., Harris, B. D., Rajashankar, K. R., & Walter, M. R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117551109 · Cited by 91 · see citing works
- Authors
- Dumoutier, L., Leemans, C., Lejeune, D., Kotenko, S. V., & Renauld, J.-C.
- Affiliations
- Ludwig Cancer Research (BE)
- Rutgers New Jersey Medical School (US)
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-10-01
- Volume
- 167
- Issue
- 7
- Pages
- 3545-3549
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2128229361
- Cited by
- 405
- References
- 17
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 10 · 2023: 7 · 2022: 8 · 2021: 13 · 2020: 10 · 2019: 14 · 2018: 11 · 2017: 18 · 2016: 16 · 2015: 15 · 2014: 18 · 2013: 15 · 2012: 17
- FWCI
- 10.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (submittedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI051139, R01AI51139)
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Keywords
- STAT3 activation, IL-19, IL-20, MDA-7, IL-20 receptor, IL-22 receptor, cytokine receptor signaling, STAT3 phosphorylation
- MeSH terms
- Interleukin-22, Interleukin-24, Carrier Proteins, Cell Line, DNA-Binding Proteins, Growth Substances, Humans, Interleukins, Models, Biological, Receptors, Cell Surface, Transfection, Signal Transduction, Transcriptional Activation, Trans-Activators, Genes, Tumor Suppressor, Interleukin-10, Genes, Reporter, Receptors, Interleukin, Macromolecular Substances, STAT3 Transcription Factor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
