Bacterial translocation is downregulated by anti-TNF-α monoclonal antibody administration in rats with cirrhosis and ascites
Abstract
Background/aims TNF-alpha is involved in the development of bacterial translocation in rats with cirrhosis. The aim of the current study was to evaluate the effect of anti-TNF-alpha mAb treatment on the incidence of bacterial translocation and systemic infections in rats with cirrhosis and ascites.Methods Thirty rats with cirrhosis and ascites were randomly assigned to receive two intraperitoneal doses of anti-TNF-alpha mAb, distilled water or immunoglobulin on days 0 and 4. On day 10, a laparotomy was performed.Results One out of 11 animals receiving anti-TNF-alpha mAb treatment, 7 out of 10 of the placebo group (p<0.01), and 5 out of 9 of the IgG group developed bacterial translocation (p<0.05). A significantly reduced number of systemic infections were observed in animals receiving anti TNF-alpha mAb treatment vs animals receiving placebo (p<0.01). TNF-alpha in serum at laparotomy in animals receiving anti-TNF-alpha mAb was higher than that in the rest of groups and was also higher in the overall series of animals showing bacterial translocation.Conclusions In the experimental model of CCl(4)-induced rat with cirrhosis and ascitic fluid, anti-TNF-alpha mAb administration decreases the incidence of bacterial translocation, in a TNF-alpha/sTNF-alpha receptor-independent manner, without increasing the risk of systemic infections.
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Anti-TNF monoclonal antibody treatment decreases bacterial translocation in experimental cirrhosis in rats.
“Treatment with an anti-TNF monoclonal antibody decreases the incidence of bacterial translocation in experimental cirrhosis in rats148.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [148]
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- Authors
- Francés, R., Chiva, M., Sánchez, E., González-Navajas, J. M., Llovet, T., Zapater, P., Soriano, G., Muñoz, C., Balanzó, J., Pérez-Mateo, M., Song, X.-Y., Guarner, C., & Such, J.
- Affiliations
- Instituto de Salud Carlos III (ES)
- Universitat Autònoma de Barcelona (ES)
- Hospital General Universitario de Alicante Doctor Balmis (ES)
- Corresponding author
- Such, José
- ORCID
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2007-05
- Volume
- 46
- Issue
- 5
- Pages
- 797-803
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W1968534453
- Cited by
- 54
- References
- 29
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 5 · 2013: 4 · 2012: 4
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Instituto de Salud Carlos III
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- bacterial translocation, anti-TNF monoclonal antibody, TNF-α, liver cirrhosis, ascites, systemic infection, carbon tetrachloride-induced liver injury
- MeSH terms
- Animals, Antibodies, Monoclonal, Ascitic Fluid, Carbon Tetrachloride, Disease Models, Animal, Injections, Intraperitoneal, Liver Cirrhosis, Experimental, Male, Peritonitis, Random Allocation, Tumor Necrosis Factor-alpha, Down-Regulation, Treatment Outcome, Rats, Sprague-Dawley, Sepsis, Bacterial Translocation, Rats
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