Cited by 54Liver Disease and TransplantationSepsis Diagnosis and TreatmentLiver physiology and pathology

Bacterial translocation is downregulated by anti-TNF-α monoclonal antibody administration in rats with cirrhosis and ascites

Francés, Rubén, Chiva, Maite, Sánchez, Elisabet, González-Navajas, José M., Llovet, Teresa, Zapater, Pedro, Soriano, Germán, Muñoz, Carlos +5 more·2007·Journal of Hepatology

Abstract

Background/aims TNF-alpha is involved in the development of bacterial translocation in rats with cirrhosis. The aim of the current study was to evaluate the effect of anti-TNF-alpha mAb treatment on the incidence of bacterial translocation and systemic infections in rats with cirrhosis and ascites.Methods Thirty rats with cirrhosis and ascites were randomly assigned to receive two intraperitoneal doses of anti-TNF-alpha mAb, distilled water or immunoglobulin on days 0 and 4. On day 10, a laparotomy was performed.Results One out of 11 animals receiving anti-TNF-alpha mAb treatment, 7 out of 10 of the placebo group (p<0.01), and 5 out of 9 of the IgG group developed bacterial translocation (p<0.05). A significantly reduced number of systemic infections were observed in animals receiving anti TNF-alpha mAb treatment vs animals receiving placebo (p<0.01). TNF-alpha in serum at laparotomy in animals receiving anti-TNF-alpha mAb was higher than that in the rest of groups and was also higher in the overall series of animals showing bacterial translocation.Conclusions In the experimental model of CCl(4)-induced rat with cirrhosis and ascitic fluid, anti-TNF-alpha mAb administration decreases the incidence of bacterial translocation, in a TNF-alpha/sTNF-alpha receptor-independent manner, without increasing the risk of systemic infections.

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Crossref · 10.1016/j.jhep.2006.11.018

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  • Anti-TNF monoclonal antibody treatment decreases bacterial translocation in experimental cirrhosis in rats.

    “Treatment with an anti-TNF monoclonal antibody decreases the incidence of bacterial translocation in experimental cirrhosis in rats148.”

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Authors
Francés, R., Chiva, M., Sánchez, E., González-Navajas, J. M., Llovet, T., Zapater, P., Soriano, G., Muñoz, C., Balanzó, J., Pérez-Mateo, M., Song, X.-Y., Guarner, C., & Such, J.
Affiliations
  • Instituto de Salud Carlos III (ES)
  • Universitat Autònoma de Barcelona (ES)
  • Hospital General Universitario de Alicante Doctor Balmis (ES)
Corresponding author
Such, José
Venue
Journal of Hepatology
Publisher
Elsevier BV
Published
2007-05
Volume
46
Issue
5
Pages
797-803
ISSN
0168-8278 (ISSN-L)
OpenAlex
W1968534453
Cited by
54
References
29
Citations by year
2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 5 · 2013: 4 · 2012: 4
FWCI
2.23
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Hepatology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Instituto de Salud Carlos III
Topics
  • Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
  • Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Keywords
bacterial translocation, anti-TNF monoclonal antibody, TNF-α, liver cirrhosis, ascites, systemic infection, carbon tetrachloride-induced liver injury
MeSH terms
Animals, Antibodies, Monoclonal, Ascitic Fluid, Carbon Tetrachloride, Disease Models, Animal, Injections, Intraperitoneal, Liver Cirrhosis, Experimental, Male, Peritonitis, Random Allocation, Tumor Necrosis Factor-alpha, Down-Regulation, Treatment Outcome, Rats, Sprague-Dawley, Sepsis, Bacterial Translocation, Rats

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