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Cited by 313Liver Disease Diagnosis and TreatmentCardiovascular and exercise physiologyPhysical Activity and Health

The DOI matches its Crossref record; 49 of the 50 references it cites were found in a registry or an index.

Effect of aerobic exercise training dose on liver fat and visceral adiposity

Keating, Shelley E., Hackett, Daniel A., Parker, Helen M., O’Connor, Helen T., Gerofi, James A., Sainsbury, Amanda, Baker, Michael K., Chuter, Vivienne H., Caterson, Ian D., George, Jacob, Johnson, Nathan A.·2015·Journal of Hepatology
DOI 10.1016/j.jhep.2015.02.022
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Abstract

Background & aims Aerobic exercise reduces liver fat and visceral adipose tissue (VAT). However, there is limited data from randomized trials to inform exercise programming recommendations. This study examined the efficacy of commonly prescribed exercise doses for reducing liver fat and VAT using a randomized placebo-controlled design.Methods Inactive and overweight/obese adults received 8 weeks of either; i) low to moderate intensity, high volume aerobic exercise (LO:HI, 50% VO 2peak, 60 min, 4d/week); ii) high intensity, low volume aerobic exercise (HI:LO, 70% VO 2peak, 45 min, 3d/week); iii) low to moderate intensity, low volume aerobic exercise (LO:LO, 50% VO 2peak, 45 min, 3d/week); or iv) placebo (PLA). Liver fat (spectroscopy) and VAT (magnetic resonance imaging) were measured before and after intervention.Results Forty-seven of the 48 (n = 12 in each group) participants completed the trial. There were no serious adverse events. There was a significant change in group × time interaction in liver fat, which reduced in HI:LO by 2.38 ± 0.73%, in LO:HI by 2.62 ± 1.00%, and in LO:LO by 0.84 ± 0.47% but not in PLA (increase of 1.10 ± 0.62%) (p = 0.04). There was a significant reduction in VAT in HI:LO (-258.38 ± 87.78 cm(3)), in LO:HI (-386.80 ± 119.5 cm(3)), and in LO:LO (-212.96 ± 105.54 cm(3)), but not in PLA (92.64 ± 83.46 cm(3)) (p = 0.03). There were no significant differences between the dose or intensity of the exercise regimen and reductions in liver fat or VAT (p > 0.05).Conclusion The study found no difference in efficacy of liver fat reduction by either aerobic exercise dose or intensity. All of the aerobic exercise regimens employed reduced liver fat and VAT by a small amount without clinically significant weight loss.

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Crossref · 10.1016/j.jhep.2015.02.022

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  1. Bonekamp, 2008, The effect of an exercise training intervention on hepatic steatosis, Hepatology, 48, 1119

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Metadata

Authors
Keating, S. E., Hackett, D. A., Parker, H. M., O’Connor, H. T., Gerofi, J. A., Sainsbury, A., Baker, M. K., Chuter, V. H., Caterson, I. D., George, J., & Johnson, N. A.
Affiliations
  • The University of Sydney (AU)
  • Australian Catholic University (AU)
  • University of Newcastle Australia (AU)
Corresponding author
George, Jacob
ORCID
Venue
Journal of Hepatology
Publisher
Elsevier BV
Published
2015-07
Volume
63
Issue
1
Pages
174-182
ISSN
0168-8278 (ISSN-L)
DOI
10.1016/j.jhep.2015.02.022
OpenAlex
W2154852507
Cited by
313
References
50
Citations by year
2026: 22 · 2025: 27 · 2024: 20 · 2023: 27 · 2022: 25 · 2021: 49 · 2020: 32 · 2019: 24 · 2018: 21 · 2017: 33 · 2016: 23 · 2015: 8
FWCI
22.21
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Hepatology (publishedVersion)
  • PubMed (publishedVersion)
  • NOVA (University of Newcastle Australia) (submittedVersion)
Topics
  • Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Keywords
aerobic exercise, exercise dose, exercise intensity, liver fat, visceral adipose tissue, non-alcoholic fatty liver disease, overweight and obesity, exercise programming, hepatic steatosis
MeSH terms
Adult, Exercise Therapy, Female, Follow-Up Studies, Humans, Male, Middle Aged, Weight Loss, Exercise, Treatment Outcome, Intra-Abdominal Fat, Resistance Training, Obesity, Abdominal

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