The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
Autoimmune hepatitis – Update 2015
Open accessAbstract
AIH is a disease of unknown cause mainly occurring in women of all ages and races. The diagnosis is made based on clinical and laboratory criteria including specific circulating autoantibodies. Liver histology contributes to the diagnosis, its value mainly regarding grading and staging of damage and the exclusion of other morbidities or comorbidities. Our understanding of the molecular pathogenesis of AIH has improved in the last decades, including the identification of autoantigens at the molecular level as well as the function of TH1, TH2, and TH17 cells. In addition, GWAS in recent and upcoming years will help us to understand better disease susceptibility and may also help us to identify patients at particular risk. Therapies with corticosteroids alone, or in combination with azathioprine will be the SOC for the time being and will continue to save lives. Immunosuppressive drugs derived from transplantation medicine, like cyclosporin A, tacrolimus or MMF, offer an alternative for difficult to treat patients, novel more specific and safer immunosuppressive agents are urgently needed. Biological agents, like anti-TNF or anti-B cell antibodies, which interfere with important signal transduction pathways of the immune system have raised expectations within the AIH scientific community. Future therapies likely to enter clinical practice are the use of anti-CD3 or Tregs. However, our next goal is to eliminate AIH as an indication for liver transplantation. Here the end is at hand.
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Self-citationClassification of chronic hepatitis: Diagnosis, grading and staging
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Self-citationSimplified criteria for the diagnosis of autoimmune hepatitis
Hennes, E. M., Zeniya, M., Czaja, A. J., Parés, A., Dalekos, G. N., Krawitt, E. L., Bittencourt, P. L., Porta, G., Boberg, K. M., Hofer, H., et al. (2008) · Hepatology · doi:10.1002/hep.22322 · Cited by 1,901
Self-citationDiagnosis and management of autoimmune hepatitis
Manns, M. P., Czaja, A. J., Gorham, J. D., Krawitt, E. L., Mieli-Vergani, G., Vergani, D., & Vierling, J. M. (2010) · Hepatology · doi:10.1002/hep.23584 · Cited by 1,442
Self-citationMeeting report: International autoimmune hepatitis group
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Identification of target antigen for SLA/LP autoantibodies in autoimmune hepatitis
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Self-citationBoberg, K. M., Chapman, R. W., Hirschfield, G. M., Lohse, A. W., Manns, M. P., & Schrumpf, E. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2010.09.002 · Cited by 555
Self-citationLapierre, P., Hajoui, O., Homberg, J.-C., & Alvarez, F. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70186-1 · Cited by 538
ANA screening: an old test with new recommendations
Meroni, P. L., & Schur, P. H. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.127100 · Cited by 533
Cited by
EASL Clinical Practice Guidelines: autoimmune hepatitis
(2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.06.030 · Cited by 1,245
Molecular mimicry and autoimmunity
Rojas, M., Restrepo-Jiménez, P., Monsalve, D. M., Pacheco, Y., Acosta-Ampudia, Y., Ramírez-Santana, C., Leung, P. S. C., Ansari, A. A., Gershwin, M. E., & Anaya, J.-M. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.10.012 · Cited by 627
Pape, S., Snijders, R. J. A. L. M., Gevers, T. J. G., Chazouilleres, O., Dalekos, G. N., Hirschfield, G. M., Lenzi, M., Trauner, M., Manns, M. P., Vierling, J. M., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2021.12.041 · Cited by 177
Self-citationGünther, C., He, G.-W., Kremer, A. E., Murphy, J. M., Petrie, E. J., Amann, K., Vandenabeele, P., Linkermann, A., Poremba, C., Schleicher, U., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci87545 · Cited by 157
Terziroli Beretta-Piccoli, B., Mieli-Vergani, G., & Vergani, D. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.10.004 · Cited by 61
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Metadata
- Authors
- Manns, M. P., Lohse, A. W., & Vergani, D.
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 62
- Issue
- 1
- Pages
- S100-S111
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W2111273085
- Cited by
- 371
- References
- 82
- FWCI
- 18.08
- Type
- journal article
- Language
- en
- Open access
- hybrid
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