The DOI matches its Crossref record; 89 of the 89 references it cites were found in a registry or an index.
Systemic therapies for intrahepatic cholangiocarcinoma
Open accessAbstract
Intrahepatic cholangiocarcinoma (iCCA) is a highly lethal hepatobiliary neoplasm whose incidence is increasing. Largely neglected for decades as a rare malignancy and frequently misdiagnosed as carcinoma of unknown primary, considerable clinical and investigative attention has recently been focused on iCCA worldwide. The established standard of care includes first-line (gemcitabine and cisplatin), second-line (FOLFOX) and adjuvant (capecitabine) systemic chemotherapy. Compared to hepatocellular carcinoma, iCCA is genetically distinct with several targetable genetic aberrations identified to date. Indeed, FGFR2 and NTRK fusions, and IDH1 and BRAF targetable mutations have been comprehensively characterised and clinical data is emerging on targeting these oncogenic drivers pharmacologically. Also, the role of immunotherapy has been examined and is an area of intense investigation. Herein, in a timely and topical manner, we will review these advances and highlight future directions of research.
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Cites
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“24 [48] Gubin MM, Zhang X, Schuster H, Caron E, Ward JP, Noguchi T, et al.”
Background
Metadata
- Authors
- Kelley, R. K., Bridgewater, J., Gores, G. J., & Zhu, A. X.
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2020-02
- Volume
- 72
- Issue
- 2
- Pages
- 353-363
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W3000723598
- Cited by
- 412
- References
- 89
- FWCI
- 50.93
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Systemic therapies for intrahepatic cholangiocarcinoma. https://app.cochat.ai/papers/10.1016/j.jhep.2019.10.009
- The paper
- Kelley, R. K., Bridgewater, J., Gores, G. J., & Zhu, A. X. (2020). Systemic therapies for intrahepatic cholangiocarcinoma. Journal of Hepatology. https://doi.org/10.1016/j.jhep.2019.10.009
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
