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BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update
Open accessAbstract
There have been major advances in the armamentarium for hepatocellular carcinoma (HCC) since the last official update of the Barcelona Clinic Liver Cancer prognosis and treatment strategy published in 2018. Whilst there have been advances in all areas, we will focus on those that have led to a change in strategy and we will discuss why, despite being encouraging, data for select interventions are still too immature for them to be incorporated into an evidence-based model for clinicians and researchers. Finally, we describe the critical insight and expert knowledge that are required to make clinical decisions for individual patients, considering all of the parameters that must be considered to deliver personalised clinical management.
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“Nevertheless, specific treatment decisions for individual patients are best made by mutidisciplinary teams of providers (for example, transplant hepatologists, surgeons, interventional radiologists and medical oncologists), nurses and patient navigators 91,167,168 .”
BackgroundMethodSelf-citationManagement of Hepatocellular Carcinoma
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Metadata
- Authors
- Reig, M., Forner, A., Rimola, J., Ferrer-Fàbrega, J., Burrel, M., Garcia-Criado, Á., Kelley, R. K., Galle, P. R., Mazzaferro, V., Salem, R., Sangro, B., Singal, A. G., Vogel, A., Fuster, J., Ayuso, C., & Bruix, J.
- Affiliations
- Hospital Clínic de Barcelona (ES)
- University of California, San Francisco (US)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- University of Milan (IT)
- Northwestern University (US)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- The University of Texas Southwestern Medical Center (US)
- Medizinische Hochschule Hannover (DE)
- Corresponding author
- Bruix, Jordi
- ORCID
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2022-03
- Volume
- 76
- Issue
- 3
- Pages
- 681-693
- ISSN
- 0168-8278 (ISSN-L)
- PMC
- PMC8866082
- OpenAlex
- W3213277274
- Cited by
- 4,319
- References
- 136
- Citations by year
- 2026: 684 · 2025: 1071 · 2024: 1166 · 2023: 962 · 2022: 424
- FWCI
- 83.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Hepatology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Fundación Científica de la Asociación Española Contra el Cáncer (PI044031)
- National Institutes of Health (R01 R01 MD012565, PI18/00768)
- Horizon 2020 Framework Programme (952103)
- Instituto de Salud Carlos III (AC16/00065, PI18/0358, PI15/00145, PI18/00542, PI19/00742, PI18/00768)
- European Association for the Study of the Liver
- Horizon 2020
- Topics
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Oncology › Renal cell carcinoma treatment
- Keywords
- hepatocellular carcinoma, Barcelona Clinic Liver Cancer staging, outcome prediction, treatment guidelines, evidence-based clinical decision-making
- MeSH terms
- Female, Carcinoma, Hepatocellular, Humans, Liver Neoplasms, Male, Middle Aged, Neoplasm Staging, Prognosis, Severity of Illness Index
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