Stop using the misidentified cell line LO2 as a human hepatocyte
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L-02 has been used in liver research in approximately 2195 studies.
“Originally presented as a human fetal hepatocyte cell line [21], L-02 has been used in liver research in approximately 2195 studies [22].”
From Genetic Insights into the Economic Toll of Cell Line Misidentification: A Comprehensive Review (2026) · cites this paper as [22]
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Ye, F., Chen, C., Qin, J., Liu, J., & Zheng, C. (2015) · The FASEB Journal · doi:10.1096/fj.14-266718 · Cited by 144 · see citing works
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Research works printed but not linked: 5
- Song Q, Zhang X, Liu W, et al. Bifidobacterium pseudolongum-generated acetate suppresses non-alcoholic fatty liver disease-associated hepatocel- lular carcinoma. J Hepatol 2023;79:1352-1365.
- Yeh HJ, Chu TH, Shen TW. Ultrastructure of continuously cultured adult human liver cell. Acta Biologiac Experimentalis Sinica 1980;13:361-369.
- Hu X, Yang T, Li C, et al. Human fetal hepatocyte line, L-02, exhibits good liver function in vitro and in an acute liver failure model. Transplant Proc 2013;45:695-700.
- Rebouissou S, Zucman-Rossi J, Moreau R, et al. Note of caution: contami- nations of hepatocellular cell lines. J Hepatol 2017;67:896-897.
- Pfeifer AM, Cole KE, Smoot DT, et al. Simian virus 40 large tumor antigen- immortalized normal human liver epithelial cells express hepatocyte char- acteristics and metabolize chemical carcinogens. Proc Natl Acad Sci USA 1993;90:5123-5127.
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Genetic Insights into the Economic Toll of Cell Line Misidentification: A Comprehensive Review
Weiskirchen, R. (2026) · Medical Sciences · doi:10.3390/medsci14010025 · Cited by 4 · see citing works
- Authors
- Shao, T., & Chen, Y.-L.
- Affiliations
- Chinese Academy of Sciences (CN)
- Corresponding author
- Chen, Yue-Lei
- ORCID
- Shao, Ting
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2024-05
- Volume
- 80
- Issue
- 5
- Pages
- e200-e201
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W4388572114
- Cited by
- 34
- References
- 1
- Citations by year
- 2026: 12 · 2025: 15 · 2024: 7
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Chinese Academy of Sciences
- Ministry of Science and Technology of the People's Republic of China
- Topics
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- human hepatocytes, cell line authentication, hepatocyte models, non-alcoholic fatty liver disease, hepatocellular carcinoma, probiotics, Bifidobacterium pseudolongum, acetate, gut-liver axis
- MeSH terms
- Cell Line, Humans, Hepatocytes
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