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Cited by 61Acne and Rosacea Treatments and EffectsDermatology and Skin DiseasesPsoriasis: Treatment and Pathogenesis

Sebaceous Gland-Rich Skin Is Characterized by TSLP Expression and Distinct Immune Surveillance Which Is Disturbed in Rosacea

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Dajnoki, Zsolt, Béke, Gabriella, Kapitány, Anikó, Mócsai, Gábor, Gáspár, Krisztián, Rühl, Ralph, Hendrik, Zoltán, Juhász, István +5 more·2017·Journal of Investigative Dermatology
DOI 10.1016/j.jid.2016.12.025
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Abstract

The microbial community exhibits remarkable diversity on topographically distinct skin regions, which may be accompanied by differences in skin immune characteristics. Our aim was to compare the immune milieu of healthy sebaceous gland-rich (SGR) and sebaceous gland-poor skin areas, and to analyze its changes in an inflammatory disease of SGR skin. For this purpose, immunohistochemical, immunocytochemical, and quantitative real-time PCR analyses of thymic stromal lymphopoietin (TSLP) and other cytokines, phenotypic immune cell markers and transcription factors were carried out in samples from sebaceous gland-poor, SGR skin and from papulopustular rosacea. TSLP mRNA and protein production was also studied in cultured keratinocytes. In SGR skin, higher TSLP expression, dendritic cell appearance without prominent activation, and T cell presence with IL-17/IL-10 cytokine milieu were detected compared with sebaceous gland-poor skin. Linoleic acid, a major sebum component, was found to induce TSLP expression dose-dependently in keratinocytes. In papulopustular rosacea, significantly decreased TSLP level and influx of inflammatory dendritic cells and T cells with IL-17/interferon-γ cytokine milieu were observed. According to our results, SGR skin is characterized by a distinct, noninflammatory immune surveillance, which may explain the preferred localization of inflammatory skin diseases, and can influence future barrier repair therapeutic concepts.

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  • Linoleic acid increases TSLP mRNA levels in keratinocytes in a dose-dependent manner.

    “Searching for the lipid(s) behind the induction, we found linoleic acid to increase TSLP mRNA levels in a dose-dependent manner.66”

    From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [66]

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Authors
Dajnoki, Z., Béke, G., Kapitány, A., Mócsai, G., Gáspár, K., Rühl, R., Hendrik, Z., Juhász, I., Zouboulis, C. C., Bácsi, A., Bíró, T., Törőcsik, D., & Szegedi, A.
Affiliations
  • University of Debrecen (HU)
  • Städtisches Klinikum Dessau (DE)
Corresponding author
Szegedi, Andrea
ORCID
Venue
Journal of Investigative Dermatology
Publisher
Elsevier BV
Published
2017-05
Volume
137
Issue
5
Pages
1114-1125
ISSN
0022-202X (ISSN-L)
DOI
10.1016/j.jid.2016.12.025
OpenAlex
W2582054853
Cited by
61
References
0
Citations by year
2026: 2 · 2025: 4 · 2024: 5 · 2023: 12 · 2022: 3 · 2021: 9 · 2020: 9 · 2019: 5 · 2018: 7 · 2017: 5
FWCI
8.13
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Investigative Dermatology (publishedVersion)
  • PubMed (publishedVersion)
  • University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion, other-oa)
  • University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords
thymic stromal lymphopoietin, papulopustular rosacea, dendritic cells, T cells, interferon-gamma, keratinocytes, linoleic acid, sebum, skin microbiome, skin barrier repair
MeSH terms
Thymic Stromal Lymphopoietin, Adult, Aged, Aged, 80 and over, Dendritic Cells, Female, Humans, Immunohistochemistry, Male, Middle Aged, RNA, Messenger, Rosacea, Sebaceous Glands, Skin, T-Lymphocytes, Keratinocytes, Case-Control Studies, Cytokines, Interleukin-10, Linoleic Acid, Interleukin-17, Young Adult, Real-Time Polymerase Chain Reaction

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