Identifying Phenotypes of Atopic Dermatitis in a Longitudinal United States Cohort Using Unbiased Statistical Clustering
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Unsupervised clustering of baseline clinical data from over 8000 children in the Pediatric Eczema Elective Registry identified 5 distinct AD subphenotypes, defined by factors such as race, age of onset, and allergy profiles, with statistically significant differences in long-term disease clearance.
“Berna et al (2020) clustered baseline clinical data from over 8000 children in the Pediatric Eczema Elective Registry and identified 5 distinct AD subphenotypes, defined by factors such as race, age of onset, and allergy profiles, with statistically significant differences in long-term disease clearance.”
From Artificial intelligence–enabled precision medicine for inflammatory skin diseases (2026) · cites this paper as Berna et al, 2020
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Dermatologist-level classification of skin cancer with deep neural networks
Esteva, A., Kuprel, B., Novoa, R. A., Ko, J., Swetter, S. M., Blau, H. M., & Thrun, S. (2017) · Nature · doi:10.1038/nature21056 · Cited by 14,362 · see citing works
A General Coefficient of Similarity and Some of Its Properties
Gower, J. C. (1971) · Biometrics · doi:10.2307/2528823 · Cited by 5,336 · see citing works
Clustering by means of medoids
Kaufman, L., & Rousseeuw, P. J. (1987) · Lirias · Cited by 1,217 · see citing works
Atopic dermatitis endotypes and implications for targeted therapeutics
Czarnowicki, T., He, H., Krueger, J. G., & Guttman‐Yassky, E. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.10.032 · Cited by 651 · see citing works
Fuxench, Z. C. C., Block, J. K., Boguniewicz, M., Boyle, J. M., Fonacier, L. S., Gelfand, J. M., Grayson, M. H., Margolis, D. J., Mitchell, L., Silverberg, J. I., et al. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.08.028 · Cited by 420 · see citing works
Self-citationPersistence of Mild to Moderate Atopic Dermatitis
Margolis, J. S., Abuabara, K., Bilker, W. B., Hoffstad, O., & Margolis, D. J. (2014) · JAMA Dermatology · doi:10.1001/jamadermatol.2013.10271 · Cited by 277 · see citing works
Self-citationStatistical Data Analysis Based on the L 1 -Norm and Related Methods.
Hawkins, D. M., & Dodge, Y. (1989) · Journal of the American Statistical Association · doi:10.2307/2289888 · Cited by 213 · see citing works
Identification of atopic dermatitis subgroups in children from 2 longitudinal birth cohorts
Paternoster, L., Savenije, O. E. M., Heron, J., Evans, D. M., Vonk, J. M., Brunekreef, B., Wijga, A. H., Henderson, A. J., Koppelman, G. H., & Brown, S. J. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.09.044 · Cited by 186 · see citing works
Thijs, J. L., Strickland, I., Bruijnzeel-Koomen, C. A. F. M., Nierkens, S., Giovannone, B., Csomor, E., Sellman, B. R., Mustelin, T., Sleeman, M. A., de Bruin-Weller, M. S., et al. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.03.023 · Cited by 163 · see citing works
Racial/Ethnic Differences in Incidence and Persistence of Childhood Atopic Dermatitis
Kim, Y., Blomberg, M., Rifas‐Shiman, S. L., Camargo, C. A., Gold, D. R., Thyssen, J. P., Litonjua, A. A., Oken, E., & Asgari, M. M. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.10.029 · Cited by 102 · see citing works
Margolis, D. J., Kim, B., Apter, A. J., Gupta, J., Hoffstad, O., Papadopoulos, M., & Mitra, N. (2014) · JAMA Dermatology · doi:10.1001/jamadermatol.2013.7954 · Cited by 96 · see citing works
Self-citationThorsteinsdóttir, S., Stokholm, J., Thyssen, J. P., Nørgaard, S. K., Thorsen, J., Chawes, B., Bønnelykke, K., Waage, J., & Bisgaard, H. F. (2018) · JAMA Dermatology · doi:10.1001/jamadermatol.2018.4061 · Cited by 82 · see citing works
Abuabara, K., Hoffstad, O., Troxel, A. B., Gelfand, J. M., McCulloch, C. E., & Margolis, D. J. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.05.031 · Cited by 47 · see citing works
Self-citationMachine learning and melanoma: The future of screening
Safran, T., Viezel-Mathieu, A., Corban, J. P. A. H., Kanevsky, A., Thibaudeau, S., & Kanevsky, J. (2017) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2017.09.055 · Cited by 30 · see citing works
Asthma and frequency of wheeze: risk factors for the persistence of atopic dermatitis in children
Garrett, J. P.-D., Apter, A. J., Hoffstad, O., Spergel, J. M., & Margolis, D. J. (2013) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2012.12.013 · Cited by 9 · see citing works
Self-citationAfrican ancestry is associated with cluster-based childhood asthma subphenotypes
Ding, L., Li, D., Wathen, M. J., Altaye, M., & Baye, T. M. (2018) · BMC Medical Genomics · doi:10.1186/s12920-018-0367-5 · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Disease modification in inflammatory skin disorders: opportunities and challenges
Bieber, T. R. M. (2023) · Nature Reviews Drug Discovery · doi:10.1038/s41573-023-00735-0 · Cited by 115 · see citing works
Immunological Aspects of Skin Aging in Atopic Dermatitis
Bocheva, G., Slominski, R. M., & Slominski, A. T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115729 · Cited by 50 · see citing works
Pomi, F. L., Papa, V., Borgia, F., Vaccaro, M., Pioggia, G., & Gangemi, S. (2024) · Life · doi:10.3390/life14040516 · Cited by 33 · see citing works
Predicting persistence of atopic dermatitis in children using clinical attributes and serum proteins
Lauffer, F., Baghin, V., Standl, M., Stark, S. P., Jargosch, M., Wehrle, J., Thomas, J., Schmidt‐Weber, C. B., Biedermann, T., Eyerich, S., et al. (2020) · Allergy · doi:10.1111/all.14557 · Cited by 31 · see citing works
Kuo, A. M.-S., Silverberg, N. B., Faith, E. F., Morgan, R. J., & Todd, P. S. (2021) · Pediatric Dermatology · doi:10.1111/pde.14755 · Cited by 30 · see citing works
Evaluating the Longitudinal Course of Atopic Dermatitis: Implications for Clinical Practice
Chovatiya, R., & Silverberg, J. I. (2022) · American Journal of Clinical Dermatology · doi:10.1007/s40257-022-00697-w · Cited by 30 · see citing works
TSLP and IL-7R Variants Are Associated with Persistent Atopic Dermatitis
Berna, R., Mitra, N., Lou, C., Wan, J., Hoffstad, O., Wubbenhorst, B. S., Nathanson, K. L., & Margolis, D. J. (2020) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.05.119 · Cited by 28 · see citing works
Self-citationTime Trends in the Prevalence of Atopic Dermatitis in Korean Children According to Age
Lee, J. Y., Kim, J., & Ahn, K. (2022) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2022.14.1.123 · Cited by 25 · see citing works
Berna, R., Mitra, N., Hoffstad, O., Wubbenhorst, B. S., Nathanson, K. L., & Margolis, D. J. (2022) · Archives of Dermatological Research · doi:10.1007/s00403-021-02319-7 · Cited by 13 · see citing works
Self-citationTian, L.-X., Li, J., Zhang, L., Ahmad, B., & Huang, L. (2021) · World Journal of Traditional Chinese Medicine · doi:10.4103/wjtcm.wjtcm_80_20 · Cited by 12 · see citing works
Atopic dermatitis phenotypes based on cluster analysis of the Danish Skin Cohort
Nymand, L. K., Nielsen, M., Vittrup, I., Halling, A., Thomsen, S. F., Egeberg, A., & Thyssen, J. P. (2023) · British Journal of Dermatology · doi:10.1093/bjd/ljad401 · Cited by 9 · see citing works
Chovatiya, R., Begolka, W. S., Thibau, I. J., & Silverberg, J. I. (2022) · Skin Health and Disease · doi:10.1002/ski2.191 · Cited by 8 · see citing works
Artificial intelligence in pediatric allergy research
Lisik, D., Basna, R., Dinh, D.-T., Hennig, C. M., Shah, S. A., Wennergren, G., Goksör, E., & Nwaru, B. I. (2024) · European Journal of Pediatrics · doi:10.1007/s00431-024-05925-5 · Cited by 8 · see citing works
Artificial intelligence–enabled precision medicine for inflammatory skin diseases
Tang, A. S., Wei, M. L., Haemel, A., La, C., Sirota, M., & Lee, E. Y. (2026) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2025.10.596 · Cited by 6 · see citing works
Artificial intelligence in atopic dermatitis: Current applications and future perspectives
Chen, Y., & Li, J. (2026) · Chinese Medical Journal · doi:10.1097/cm9.0000000000004020 · Cited by 7 · see citing works
Berna, R., Mitra, N., Hoffstad, O., Wubbenhorst, B. S., Nathanson, K. L., & Margolis, D. J. (2021) · JID Innovations · doi:10.1016/j.xjidi.2021.100046 · Cited by 5 · see citing works
Self-citationAtopic Dermatitis and Artificial Intelligence
Vakirlis, E., Dermitzakis, I., & Sotiriou, E. (2026) · Springer eBooks · doi:10.1007/978-3-032-15614-3_10 · Cited by 1 · see citing works
Artificial intelligence-enabled precision medicine for inflammatory skin diseasesPreprint
Tang, A., Wei, M. L., Haemel, A. K., La, C., Sirota, M., & Lee, E. Y. (2025) · PubMed · doi:10.48550/arxiv.2505.09527 · Cited by 5 · see citing works
- Authors
- Berna, R., Mitra, N., Hoffstad, O., Wan, J., & Margolis, D. J.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Berna, Ronald
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2020-02
- Volume
- 140
- Issue
- 2
- Pages
- 477-479
- ISSN
- 0022-202X (ISSN-L)
- PMC
- PMC6983356
- OpenAlex
- W2969422761
- Cited by
- 18
- References
- 16
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 2
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Valeant Pharmaceuticals International
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (P30-AR069589, R01-AR069062, T32-AR007465)
- Pfizer
- University of Pennsylvania (R01-AR060962, R01-AR070873, R01-DK116199)
- Sunovion
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Health Professions › Health Information Management › Artificial Intelligence in Healthcare
- Keywords
- atopic dermatitis, phenotypes, clustering, machine learning, longitudinal cohort, patient subgroups, skin disease classification
- MeSH terms
- Machine Learning, Child, Child, Preschool, Dermatitis, Atopic, Diagnosis, Computer-Assisted, Female, Humans, Infant, Infant, Newborn, Longitudinal Studies, Male, Phenotype, Registries, Severity of Illness Index, United States, Cluster Analysis, Age of Onset
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