Fatal co-infection with swine origin influenza virus A/H1N1 and community-acquired methicillin-resistant Staphylococcus aureus
Abstract
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) co-infection has been described previously in association with respiratory tract infection caused by seasonal influenza A viruses, but not with swine origin influenza A (H1N1) virus (S-OIV). We report the clinical and pathological findings of the first death with fulminant co-infection by CA-MRSA. Since early empirical treatment with beta-lactam plus fluoroquinolone or macrolides is often initiated before specimen collections, bacterial co-infection in S-OIV may have been under-reported.
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Although few data are available, bacterial pneumonia is complicating around 30% of fatal cases of the 2009 novel pandemic H1N1 influenza, with S. aureus the most commonly recognized pathogen.
“Although few data are available, it seems that bacterial pneumonia is complicating around 30% of fatal cases, with S. aureus the most commonly recognized pathogen [12,15,16].”
From Influenza virus primes mice for pneumonia from Staphylococcus aureus. (2011) · cites this paper as [16]
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Influenza virus primes mice for pneumonia from Staphylococcus aureus.
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- Authors
- Cheng, V. C. C., Lau, Y.-K., Lee, K.-L., Yiu, K.-H., Chan, K.-H., Ho, P.-L., & Yuen, K.-Y.
- Affiliations
- Queen Mary Hospital (CN)
- Ruttonjee Hospital (CN)
- Pamela Youde Nethersole Eastern Hospital (CN)
- Corresponding author
- Yuen, Kwok-Yung
- Venue
- Journal of Infection
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 59
- Issue
- 5
- Pages
- 366-370
- ISSN
- 0163-4453 (ISSN-L)
- OpenAlex
- W2018074188
- Cited by
- 32
- References
- 24
- Citations by year
- 2025: 1 · 2019: 1 · 2018: 1 · 2016: 1 · 2015: 2 · 2013: 1 · 2012: 2
- FWCI
- 5.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Infection (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Keywords
- community-associated methicillin-resistant Staphylococcus aureus, bacterial co-infection, fatal outcome, fulminant infection, respiratory infections, empirical antibiotic therapy
- MeSH terms
- Adult, Antigens, Viral, Humans, Influenza, Human, Lung, Male, Staphylococcal Infections, Community-Acquired Infections, Fatal Outcome, Influenza A Virus, H1N1 Subtype, Methicillin-Resistant Staphylococcus aureus
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