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Effectiveness of influenza vaccines in preventing severe influenza illness among adults: A systematic review and meta- analysis of test-negative design case-control studies
Open accessAbstract
Objectives Summary evidence of influenza vaccine effectiveness (IVE) against hospitalized influenza is lacking. We conducted a meta-analysis of studies reporting IVE against laboratory-confirmed hospitalized influenza among adults.Methods We searched Pubmed (January 2009 to November 2016) for studies that used test-negative design (TND) to enrol patients hospitalized with influenza-associated conditions. Two independent authors selected relevant articles. We calculated pooled IVE against any and (sub)type specific influenza among all adults, and stratified by age group (18-64 and 65 years and above) using random-effects models.Results We identified 3411 publications and 30 met our inclusion criteria. Between 2010-11 and 2014-15, the pooled seasonal IVE was 41% (95%CI:34;48) for any influenza (51% (95%CI:44;58) among people aged 18-64y and 37% (95%CI:30;44) among ≥65 years). IVE was 48% (95%CI:37;59),37% (95%CI:24;50) and 38% (95%CI:23;53) against influenza A(H1N1)pdm09, A(H3N2) and B, respectively. Among persons aged ≥65 year, IVE against A(H3N2) was 43% (95%CI:33;53) in seasons when circulating and vaccine strains were antigenically similar and 14% (95%CI:-3;30) when A(H3N2) variant viruses predominated.Conclusions Influenza vaccines provided moderate protection against influenza-associated hospitalizations among adults. They seemed to provide low protection among elderly in seasons where vaccine and circulating A(H3N2) strains were antigenically variant.
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“Moreover, a recent review identified that vaccine effectiveness in adults aged >65 years was only 37% compared to 51% for working-age adults (Rondy et al., 2017).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Rondy et al., 2017
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Metadata
- Authors
- Rondy, M., El Omeiri, N., Thompson, M. G., Levêque, A., Moren, A., & Sullivan, S. G.
- Affiliations
- Université de Bordeaux (FR)
- Centers for Disease Control and Prevention (US)
- Peter Doherty Institute (AU)
- Corresponding author
- Rondy, Marc
- Venue
- Journal of Infection
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 75
- Issue
- 5
- Pages
- 381-394
- ISSN
- 0163-4453 (ISSN-L)
- PMC
- PMC5912669
- OpenAlex
- W2754200907
- Cited by
- 247
- References
- 85
- Citations by year
- 2026: 20 · 2025: 31 · 2024: 29 · 2023: 34 · 2022: 30 · 2021: 35 · 2020: 38 · 2019: 16 · 2018: 13 · 2017: 1
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Infection (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Funders
- National Institutes of Health (CC999999)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Social Sciences › Health › Vaccine Coverage and Hesitancy
- Keywords
- influenza vaccine effectiveness, seasonal influenza vaccine, influenza-associated hospitalizations, test-negative design, influenza A(H1N1)pdm09, H3N2, influenza B, antigenic mismatch, older adults, adults
- MeSH terms
- Immunogenicity, Vaccine, Adult, Hospitalization, Humans, Influenza, Human, Influenza Vaccines, Case-Control Studies, Treatment Outcome
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