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Cited by 175Viral-associated cancers and disordersHIV-related health complications and treatmentsHIV/AIDS Research and Interventions

Assessing the impact of HAART on the incidence of defining and non-defining AIDS cancers among patients with HIV/AIDS: a systematic review

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Cobucci, Ricardo Ney Oliveira, Lima, Paulo Henrique, de Souza, Pollyana Carvalho, Costa, Vanessa Viana, Cornetta, Maria da Conceição de Mesquita, Fernandes, José Veríssimo, Gonçalves, Ana Katherine·2015·Journal of Infection and Public Health
DOI 10.1016/j.jiph.2014.08.003
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Abstract

After highly active antiretroviral therapy (HAART) became widespread, several studies demonstrated changes in the incidence of defining and non-defining AIDS cancers among HIV/AIDS patients. We conducted a systematic review of observational studies evaluating the incidence of malignancies before and after the introduction of HAART in people with HIV/AIDS. Eligible studies were searched up to December 2012 in the following databases: Pubmed, Embase, Scielo, Cancerlit and Google Scholar. In this study, we determined the cancer risk ratio by comparing the pre- and post-HAART eras. Twenty-one relevant articles were found, involving more than 600,000 people with HIV/AIDS and 10,891 new cases of cancers. The risk for the development of an AIDS-defining cancer decreased after the introduction of HAART: Kaposi's sarcoma (RR=0.30, 95% CI: 0.28-0.33) and non-Hodgkin's lymphoma (RR=0.52, 95% CI: 0.48-0.56), in contrast to invasive cervical cancer (RR=1.46, 95% CI: 1.09-1.94). Among the non-AIDS-defining cancers, the overall risk increased after the introduction of HAART (RR=2.00, 95% CI: 1.79-2.23). The incidence of AIDS-defining cancers decreased and the incidence of non-AIDS-defining cancers increased after the early use of HAART, probably due to better control of viral replication, increased immunity and increased survival provided by new drugs.

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  1. Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 2000;283:2008-12.
  2. Crum-Cianflone NF. HIV and the Gastrointestinal Tract. Infect Dis Clin Pract (Baltim, MD) 2010;18:283-5.

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Authors
Cobucci, R. N. O., Lima, P. H., de Souza, P. C., Costa, V. V., Cornetta, M. D. C. D. M., Fernandes, J. V., & Gonçalves, A. K.
Affiliations
  • Universidade Federal do Rio Grande do Norte (BR)
  • Universidade Potiguar (BR)
Corresponding author
Cobucci, Ricardo Ney Oliveira
ORCID
Venue
Journal of Infection and Public Health
Publisher
Elsevier BV
Published
2015-01
Volume
8
Issue
1
Pages
1-10
ISSN
1876-0341 (ISSN-L)
DOI
10.1016/j.jiph.2014.08.003
OpenAlex
W2069403022
Cited by
175
References
45
Citations by year
2026: 4 · 2025: 9 · 2024: 12 · 2023: 14 · 2022: 15 · 2021: 23 · 2020: 11 · 2019: 17 · 2018: 23 · 2017: 23 · 2016: 10 · 2015: 14
FWCI
1.78
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Infection and Public Health (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
  • Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Keywords
highly active antiretroviral therapy, HIV/AIDS, AIDS-defining cancers, non-AIDS-defining cancers, cancer incidence, Kaposi's sarcoma, non-Hodgkin lymphoma, invasive cervical cancer, HIV-associated malignancies
MeSH terms
Acquired Immunodeficiency Syndrome, Uterine Cervical Neoplasms, Female, Humans, Lymphoma, Non-Hodgkin, Male, Sarcoma, Kaposi, Cohort Studies, Lymphoma, AIDS-Related, AIDS-Related Opportunistic Infections, Antiretroviral Therapy, Highly Active, Observational Studies as Topic

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