Exercise therapy correlates with improving renal function through modifying lipid metabolism in patients with cardiovascular disease and chronic kidney disease
Open accessAbstract
Background Patients with cardiovascular disease (CVD) and chronic kidney disease (CKD) are at high risk of cardiovascular mortality, thus therapies to improve renal function should be clinically investigated. Methods and results We divided consecutive patients with CVD and CKD (n=19) into exercise (n=10) and non-exercise (n=9) therapy groups. Exercise therapy for 12 weeks significantly improved the anaerobic metabolic threshold (AT-V O₂) and high-density lipoprotein cholesterol (HDL-C) levels, and reduced triglyceride levels. Exercise therapy also improved estimated glomerular filtration rate (eGFR). Change in eGFR correlated significantly and positively with change in AT-V O₂ and HDL-C, and negatively with change in triglyceride levels. Conclusions Exercise therapy correlates with improving renal function in CVD patients with CKD through modifying lipid metabolism. Exercise therapy could be an effective clinical strategy to improve renal function.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
High risk of performance bias was granted to more than 75% of the included studies.
“high risk of performance bias was granted to more than 75% of the studies [7, 9, 10, 13, 15–18, 20, 21].”
From Exercise therapy improves eGFR, and reduces blood pressure and BMI in non-dialysis CKD patients: evidence from a meta-analysis (2019) · cites this paper as [9]
The Methods section (page not provided) describes this study as an open-labeled clinical trial, which supports a concern about performance bias in this study. The paper does not assess performance bias across the citing document’s included studies or establish that more than 75% were rated high risk. (LLM, conf=0.84)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Kelley, G. A., Kelley, K. S., & Franklin, B. (2006) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-200605000-00002 · Cited by 106 · see citing works
Flagged first, then by citations
Research works printed but not linked: 11
- Manjunath G, Tighiouart H, Ibrahim H, MacLeod B, Salem DN, Griffith JL, Coresh J, Levey AS, Sarnak MJ. Level of kidney function as a risk factor for atherosclerotic cardiovascular out- comes in the community. J Am Coll Cardiol 2003;41:47-55.
- Kohzuki M, Kamimoto M, Wu XM, Xu HL, Kawamura T, Mori N, Nagasaka M, Kurosawa H, Minami N, Kanazawa M, Saito T, Yoshida K. Renal protective effects of chronic exercise and anti- hypertensive therapy in hypertensive rats with chronic renal failure. J Hypertens 2001;19:1877-82.
- Osato S, Onoyama K, Okuda S, Sanai T, Hori K, Fujishima M. Effect of swimming exercise on the progress of renal dysfunction in rat with focal glomerulosclerosis. Nephron 1990;55:306-11.
- Moinuddin I, Leehey DJ. A comparison of aerobic exercise and resistance training in patients with and without chronic kidney disease. Adv Chronic Kidney Dis 2008;15:83-96.
- Schaeffner ES, Kurth T, Curhan GC, Glynn RJ, Rexrode KM, Baigent C, Buring JE, Gaziano JM. Cholesterol and the risk of renal dysfunction in apparently healthy men. J Am Soc Nephrol 2003;14:2084-91.
- Onishi T, Shimada K, Sunayama S, Ohmura H, Sumide T, Masaki Y, Fukao K, Nishitani M, Kume A, Sato H, Naito H, Kawai S, Amano A, Daida H. Effects of cardiac rehabilitation in patients with metabolic syndrome after coronary artery bypass grafting. J Cardiol 2009;53:381-7.
- Harper CR, Jacobson TA. Managing dyslipidemia in chronic kid- ney disease. J Am Coll Cardiol 2008;51:2375-84.
- Abrass CK. Lipid metabolism and renal disease. Contrib Nephrol 2006;151:106-21.
- Sharyo S, Kumagai K, Yokota-Ikeda N, Ito K, Ikeda M. Ame- lioration of renal ischemia-reperfusion injury by inhibition of IL-6 production in the poloxamer 407-induced mouse model of hyperlipidemia. J Pharmacol Sci 2009;110:47-54.
- Scheuer H, Gwinner W, Hohbach J, Gröne EF, Brandes RP, Malle E, Olbricht CJ, Walli AK, Gröne HJ. Oxidant stress in hyperlipidemia-induced renal damage. Am J Physiol Renal Phys- iol 2000;278:F63-74.
- Athyros VG, Kakafika AI, Papageorgiou AA, Pagourelias ED, Savvatianos SD, Elisaf M, Karagiannis A, Tziomalos K, Mikhai- lidis DP. Statin-induced increase in HDL-C and renal function in coronary heart disease patients. Open Cardiovasc Med J 2007;1:8-14.
Cited by
Sorted by citations
Greenwood, S. A., Koufaki, P., Mercer, T. H., MacLaughlin, H. L., Rush, R., Lindup, H., O’Connor, E., Jones, C., Hendry, B. M., Macdougall, I. C., et al. (2015) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2014.07.015 · Cited by 193 · see citing works
Zhang, L., Wang, Y., Xiong, L., Luo, Y., Huang, Z., & Yi, B. (2019) · BMC Nephrology · doi:10.1186/s12882-019-1586-5 · Cited by 132 · see citing works
Baria, F., Kamimura, M. A., Aoike, D. T., Ammirati, A., Leister Rocha, M., de Mello, M. T., & Cuppari, L. (2014) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gft529 · Cited by 110 · see citing works
- Authors
- Toyama, K., Sugiyama, S., Oka, H., Sumida, H., & Ogawa, H.
- Affiliations
- Kumamoto University (JP)
- Corresponding author
- Sugiyama, Seigo
- Venue
- Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 56
- Issue
- 2
- Pages
- 142-146
- ISSN
- 0914-5087 (ISSN-L)
- OpenAlex
- W1967122288
- Cited by
- 113
- References
- 1
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 9 · 2023: 11 · 2022: 9 · 2021: 8 · 2020: 5 · 2019: 8 · 2018: 3 · 2017: 9 · 2016: 6 · 2015: 6 · 2014: 12 · 2013: 9 · 2012: 4
- FWCI
- 15.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Kumamoto University Repository (Kumamoto University) (submittedVersion)
- Kumamoto University Repository System (submittedVersion)
- Funders
- Japan Society for the Promotion of Science (22590786)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- exercise therapy, chronic kidney disease, cardiovascular disease, renal function, lipid metabolism, HDL cholesterol, triglycerides, estimated glomerular filtration rate
- MeSH terms
- Aged, Cardiovascular Diseases, Exercise Therapy, Female, Glomerular Filtration Rate, Humans, Kidney, Kidney Failure, Chronic, Cholesterol, HDL, Male, Triglycerides, Lipid Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
