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Cited by 106Cardiovascular and exercise physiologyLipoproteins and Cardiovascular HealthPhysical Activity and Health

Aerobic Exercise and Lipids and Lipoproteins in Patients With Cardiovascular Disease: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

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Kelley, George A., Kelley, Kristi S., Franklin, Barry·2006·Journal of Cardiopulmonary Rehabilitation
DOI 10.1097/00008483-200605000-00002PMC PMC2447859
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Abstract

Purpose Use the meta-analytic approach to examine the effects of aerobic exercise on lipids and lipoproteins in adults with cardiovascular disease (CVD). Methods Studies were retrieved via electronic databases, review of reference lists from retrieved articles, including reviews, and hand searching. Inclusion criteria were: (1) randomized controlled trials, (2) aerobic exercise >or=4 weeks as an intervention, (3) studies published in English language only between January 1, 1955 and January 1, 2005, (4) studies published in journals or as dissertations or master's theses, (5) human subjects >or=18 years, (6) all subjects diagnosed with some type of CVD, and (7) pre and post data available for total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and/or triglycerides (TG). Random-effects models were used for data analysis. Results Of the more than 3,000 studies reviewed, a total of 10 representing 1,260 subjects (580 exercise, 680 control) were included in our analysis. There was a statistically significant increase of 9% in HDL-C (mean +/- SEM, 3.7 +/- 1.3 mg/dL; 95% CI, 1.2 to 6.1 mg/dL) and a statistically significant decrease of 11% in TG (-19.3 +/- 5.4 mg/dL; 95% CI, -30.1 to -8.5 mg/dL), but no statistically significant decreases in TC or LDL-C (TC, -8.8 +/- 6.8 mg/dL; 95% CI, -22.3 to 4.7 mg/dL; LDL-C, -7.7 +/- 6.0 mg/dL; 95% CI, -19.5 to 4.2 mg/dL). Conclusions The present findings suggest that chronic aerobi…

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  • Regular exercise improves blood pressure control and lipid profiles, reduces the incidence of diabetes and myocardial infarction, and increases life expectancy.

    “Regular exercise improves blood pressure control and lipid profiles, reduces the incidence of diabetes and myocardial infarction, and increases life expectancy.6–9”

    From Lifelong endurance exercise and its relation with coronary atherosclerosis (2023) · cites this paper as [7]

  • Increased cardiorespiratory fitness is associated with a progressive reduction of cardiovascular events.

    “Increased cardiorespiratory fitness is associated with a progressive reduction of cardiovascular events, which would seem to be at odds with the aforementioned link between lifelong exercise load and increased coronary atherosclerosis.”

    From Lifelong endurance exercise and its relation with coronary atherosclerosis (2023) · cites this paper as [7]

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Authors
Kelley, G. A., Kelley, K. S., & Franklin, B.
Affiliations
West Virginia University (US)
Corresponding author
  • Kelley, George A.
  • Kelley, Kristi S.
ORCID
Venue
Journal of Cardiopulmonary Rehabilitation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2006-05
Volume
26
Issue
3
Pages
131-139
ISSN
0883-9212 (ISSN-L)
DOI
10.1097/00008483-200605000-00002
PMC
PMC2447859
OpenAlex
W2129735711
Cited by
106
References
37
Citations by year
2026: 4 · 2025: 2 · 2023: 2 · 2022: 5 · 2021: 9 · 2020: 6 · 2019: 5 · 2018: 4 · 2017: 6 · 2016: 3 · 2015: 4 · 2014: 8 · 2013: 6 · 2012: 6
FWCI
1.34
Type
journal article
Language
en
Open access
Locations
  • Journal of Cardiopulmonary Rehabilitation (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Heart, Lung, and Blood Institute (R01HL069802)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
Keywords
aerobic exercise, cardiovascular disease, lipids, lipoproteins, HDL cholesterol, triglycerides, total cholesterol, LDL cholesterol, exercise therapy, dyslipidemia, sex differences, men, adults, randomized controlled trials, cardiovascular risk reduction, lifestyle intervention, physical activity interventions, exercise intensity, exercise duration, exercise frequency
MeSH terms
Cardiac Rehabilitation, Cardiovascular Diseases, Exercise Therapy, Humans, Lipids, Lipoproteins, Retrospective Studies, Biomarkers, Exercise, Randomized Controlled Trials as Topic

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