The DOI matches its Crossref record; 179 of the 179 references it cites were found in a registry or an index.
Magnesium-based biomaterials as emerging agents for bone repair and regeneration: from mechanism to application
Open accessAbstract
Magnesium (Mg) is the fourth most abundant element in the human body and is important in terms of specific osteogenesis functions. Here, we provide a comprehensive review of the use of magnesium-based biomaterials (MBs) in bone reconstruction. We review the history of MBs and their excellent biocompatibility, biodegradability and osteopromotive properties, highlighting them as candidates for a new generation of biodegradable orthopedic implants. In particular, the results reported in the field-specific literature (280 articles) in recent decades are dissected with respect to the extensive variety of MBs for orthopedic applications, including Mg/Mg alloys, bioglasses, bioceramics, and polymer materials. We also summarize the osteogenic mechanism of MBs, including a detailed section on the physiological process, namely, the enhanced osteogenesis, promotion of osteoblast adhesion and motility, immunomodulation, and enhanced angiogenesis. Moreover, the merits and limitations of current bone grafts and substitutes are compared. The objective of this review is to reveal the strong potential of MBs for their use as agents in bone repair and regeneration and to highlight issues that impede their clinical translation. Finally, the development and challenges of MBs for transplanted orthopedic materials are discussed.
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Cited by
Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration
Yuan, X., Zhu, W., Yang, Z., He, N., Chen, F., Han, X., & Zhou, K. (2024) · Advanced Materials · doi:10.1002/adma.202403641 · Cited by 339
A review on magnesium alloys for biomedical applications
Zhang, T., Wang, W., Liu, J., Wang, L., Tang, Y., & Wang, K. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.953344 · Cited by 208
Zheng, Y., Huang, C., Li, Y., Gao, J., Yang, Y., Zhao, S., Che, H., Yang, Y., Yao, S., Li, W., et al. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.05.023 · Cited by 63
Zhang, P., Wang, T., Qian, J., Qin, H., Liu, P., Xiong, A., Udduttula, A., Wang, D., Zeng, H., & Chen, Y. (2024) · Regenerative Biomaterials · doi:10.1093/rb/rbae049 · Cited by 7
Metadata
- Authors
- Zhou, H., Liang, B., Jiang, H., Deng, Z., & Yu, K.
- Venue
- Journal of Magnesium and Alloys
- Publisher
- Elsevier BV
- Published
- 2021-05
- Volume
- 9
- Issue
- 3
- Pages
- 779-804
- ISSN
- 2213-9567 (ISSN-L)
- OpenAlex
- W3140559517
- Cited by
- 377
- References
- 179
- FWCI
- 12.78
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zhou, H., Liang, B., Jiang, H., Deng, Z., & Yu, K. (2021). Magnesium-based biomaterials as emerging agents for bone repair and regeneration: from mechanism to application. Journal of Magnesium and Alloys. https://doi.org/10.1016/j.jma.2021.03.004
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
