The Ordering of Corneal Collagen Fibrils with Increasing Ionic Strength
Abstract
The fixed stromal charge of bovine corneas, osmotically clamped at physiological hydration, was altered by regulating the amount of chloride ions bound to the matrix. We measured the local fibrillar collagen order using X-ray diffraction methods. As the bound anions increased up to physiological values, the local fibrillar order increased to an optimal value. The coherence distance (t) approximately doubles to a maximum value (409 nm) from 10 mM NaCl to 154 mM NaCl. This then slowly decreased as the bathing solution increased to 1000 mM. In contrast the diameter of the collagen fibrils were minimal at physiological NaCl.
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The corneal stroma contains specialised glycoproteins and ions that play an important role in organising the collagen fibrils in order to maintain transparency.
“It also contains specialised glycoproteins (Labat-Robert and Robert, 2012, Wall et al., 1988, Cooper et al., 2006) and, of course, ions that play an important role in organising the collagen fibrils in order to maintain transparency (Kostyuk et al., 2002, Regini et al., 2004).”
From Corneal structure and transparency (2015) · cites this paper as Regini et al., 2004
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Corneal structure and transparency
Meek, K. M., & Knupp, C. (2015) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2015.07.001 · Cited by 853 · see citing works
- Authors
- Regini, J. W., Elliott, G. F., & Hodson, S. A.
- Affiliations
- Cardiff University (GB)
- University of Oxford (GB)
- Corresponding author
- Regini, J.W.
- ORCID
- Regini, J.W.
- Venue
- Journal of Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2004-02
- Volume
- 336
- Issue
- 1
- Pages
- 179-186
- ISSN
- 0022-2836 (ISSN-L)
- OpenAlex
- W2047715956
- Cited by
- 19
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2021: 1 · 2019: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2012: 1
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Engineering and Physical Sciences Research Council
- Topics
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Corneal surgery and disorders
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Electrostatics and Colloid Interactions
- Keywords
- corneal collagen fibrils, ionic strength, chloride, collagen fibril diameter, bovine cornea, sodium chloride
- MeSH terms
- Animals, Cattle, Collagen, Cornea, Osmolar Concentration, Sodium Chloride, Water, X-Ray Diffraction
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