The Human LINE-1 Retrotransposon Creates DNA Double-strand Breaks

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Items 301–400 of 518

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2. Arsenic Induces VL30 Retrotransposition: The Involvement of Oxidative Stress and Heat-Shock Protein 70
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3. Small RNAs and cancerogenesis
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4. The selection arena in early human blastocysts resolves the pluripotent inner cell mass
   Manvendra Singh, Thomas J. Widmann, Vikas Bansal, José Luis Cortés, Gerald G. Schumann, Stephanie Wunderlich, Ulrich Martin, Jose Luis Garcia-Perez, Laurence D. Hurst, Zsuzsanna Izsvák · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
5. Nuclear translocation of the LINE-1 encoded ORF1 protein alters nuclear envelope integrity in human neurons
   Rania Znaidi, Olivia Massiani-Beaudoin, Philippe Mailly, Héloïse Monnet, Tom Bonnifet, The Brainbank Neuro-CEB Neuropathology Network, Rajiv L. Joshi, Julia Fuchs · 2025 · Brain Research
6. SCIFER: approach for analysis of LINE-1 mRNA expression in single cells at a single locus resolution
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7. LINE-1 retrotransposition events affect endothelial proliferation and migration
   Ferya Banaz‐Yaşar, Gyde Steffen, Jessica Hauschild, Birthe M. Bongartz, Gerald G. Schumann, Süleyman Ergün · 2010 · Histochemistry and Cell Biology
8. Chromoanagenesis phenomena and their formation mechanisms
   Franck Pellestor, Jean‐Baptiste Gaillard, Anouck Schneider, Jacques Puechberty, Vincent Gâtinois · 2021 · Elsevier eBooks
9. Navigating the brain and aging: exploring the impact of transposable elements from health to disease
   Anna Le Breton, Margarida P. Bettencourt, Anne-Valérie Gendrel · 2024 · Frontiers in Cell and Developmental Biology
10. DNA repair protein Rad18 restricts LINE-1 mobility
    Yasuo Ariumi, Koudai Kawano, Mariko Yasuda-Inoue, Misao Kuroki, Hiroyuki Fukuda, Rokeya Siddiqui, Priscilla Turelli, Satoshi Tateishi · 2018 · Scientific Reports
11. Identification of L1 ORF2p sequence important to retrotransposition using Bipartile Alu retrotransposition (BAR)
    Claiborne M. Christian, Dawn L. deHaro, Kristine J. Kines, Mark J. Sokolowski, Victoria P. Belancio · 2016 · Nucleic Acids Research
12. Association of new deletion/duplication region at chromosome 1p21 with intellectual disability, severe speech deficit and autism spectrum disorder-like behavior: an all-in approach to solving the DPYD enigma
    Lukrecija Brečević, Martina Rinčić, Željka Krsnik, Goran Sedmak, Ahmed Basheer Hamid, Nadezda Kosyakova, Ivan Galić, Thomas Liehr, Fran Borovečki · 2015 · Translational Neuroscience
13. L1 retrotransposon expression in circulating tumor cells
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14. Inhibition of LINE-1 retrotransposition represses telomere reprogramming during mouse 2-cell embryo development
    Fang Wang, Isaac J. Chamani, Danxia Luo, Kasey Chan, Paula Andrea Navarro, David Lawrence Keefe · 2021 · Journal of Assisted Reproduction and Genetics
15. Non‐canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets
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16. Somatic Mosaicism in Brain Disorders
    Rachel R. Corrigan, Lauren Mashburn‐Warren, Hyojung Yoon, Tracy A. Bedrosian · 2024 · Annual Review of Pathology Mechanisms of Disease
17. Low dependency of retrotransposition on the ORF1 protein of the zebrafish LINE, ZfL2-1
    Masaki Kajikawa, Tomohiro Sugano, Ryosuke Sakurai, Norihiro Okada · 2012 · Gene
18. H2O2 signals via iron induction of VL30 retrotransposition correlated with cytotoxicity
    Sofia Konisti, Stefania Mantziou, Georgios S. Markopoulos, Soteroula Thrasyvoulou, George Vartholomatos, Ioannis Sainis, Evangelos Kolettas, Dimitrios Noutsopoulos, Theodore Tzavaras · 2012 · Free Radical Biology and Medicine
19. Circular retrotransposition products generated by a LINE retrotransposon
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20. Developmental regulators moonlighting as transposons defense factors
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21. Targeting transposable elements in cancer: developments and opportunities
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22. Long interspersed nucleotide acid element-1 ORF-1 protein promotes proliferation and invasion of human colorectal cancer LoVo cells through enhancing ETS-1 activity
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23. WiFi Related Radiofrequency Electromagnetic Fields Promote Transposable Element Dysregulation and Genomic Instability in Drosophila melanogaster
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24. Transposable Elements: Emerging Therapeutic Targets in Neurodegenerative Diseases
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25. LINE-1 Retrotransposition Events Regulate Gene Expression After X-Ray Irradiation
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26. A genome-wide strategy to identify causes and consequences of retrotransposon expression finds activation by BRCA1 in ovarian cancer
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27. piRNA function in germline development
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28. Expression of Retroelements in Mammalian Gametes and Embryos
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29. On the interface of aging, cancer, and neurodegeneration with SIRT6 and L1 retrotransposon protein interaction network
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30. Causes and consequences of DNA double-stranded breaks in cardiovascular disease
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31. Approaches to repurposing reverse transcriptase antivirals in cancer
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32. Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B
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33. HCV Activates Somatic L1 Retrotransposition—A Potential Hepatocarcinogenesis Pathway
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34. Retrotransposon-derived transcripts and their functions in immunity and disease
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35. Human cytomegalovirus harnesses host L1 retrotransposon for efficient replication
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36. Impact of LINE-1 hypomethylation on the clinicopathological and molecular features of colorectal cancer patients
    Tai‐Chuan Kuan, Pei-Ching Lin, Shung‐Haur Yang, Chun‐Chi Lin, Yuan‐Tzu Lan, Hung‐Hsin Lin, Wen-Yi Liang, Wei-Shone Chen, Jen-Kou Lin, Jeng‐Kai Jiang et al. · 2018 · PLoS ONE
37. Polymer‐based dense fluidic networks for high throughput screening with ultrasensitive fluorescence detection
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38. L1 Regulation in Mouse and Human Germ Cells
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39. BST2 Suppresses LINE-1 Retrotransposition by Reducing the Promoter Activity of LINE-1 5′ UTR
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40. Circadian Dysregulation and Melatonin Rhythm Suppression in the Context of Aging
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41. Regulation of mammalian LINE1 retrotransposon transcription
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42. A new mechanism to ensure integration during LINE retrotransposition: A suggestion from analyses of the 5′ extra nucleotides
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43. The importance of L1 ORF2p cryptic sequence to ORF2p fragment-mediated cytotoxicity
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44. Genomic instability and aging: Causes and consequences
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45. Deciphering lung adenocarcinoma evolution and the role of LINE-1 retrotransposition
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46. Rapid DNA cleavage by the LINE-1 endonuclease proximal to DNA ends and at mismatches
    Bryant D. Miller, Benedict A. Smail, Trevor van Eeuwen, Hanna M. Kodama, Kazuma Kondo, Hua Liang Jiang, Allison O’Brien, Nan Dai, Robert J. Trachman, Shengxi Guan et al. · 2025 · Journal of Biological Chemistry
47. Large Deletions, Cleavage of the Telomeric Repeat Sequence, and Reverse Transcriptase-Mediated DNA Damage Response Associated with Long Interspersed Element-1 ORF2p Enzymatic Activities
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48. Locus-specific LINE-1 expression in clinical ovarian cancer specimens at the single-cell level
    Anna Perkiö, Barun Pradhan, Fatih Genç, Anna Pirttikoski, Sanna Pikkusaari, Erdoğan Pekcan Erkan, Matías Marín Falco, Kaisa Huhtinen, Sara Narva, Johanna Hynninen et al. · 2024 · Scientific Reports
49. Global cerebral ischemia induces increased expression of multiple retrotransposons
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50. Epigenetic regulation and role of LINE-1 retrotransposon in embryogenesis
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51. Amplification Dynamics of Platy-1 Retrotransposons in the Cebidae Platyrrhine Lineage
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52. Divergent genome evolution caused by regional variation in DNA gain and loss between human and mouse
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53. Chimeric chromosome landscapes of human somatic cell cultures show dependence on stress and regulation of genomic repeats by CGGBP1
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54. A novel role of TRIM28 B box domain in L1 retrotransposition and ORF2p-mediated cDNA synthesis
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55. Interactions of Transposons with the Cellular DNA Repair Machinery
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56. Regulation of Retrotransposition of Long Interspersed Element-1 by Mitogen-Activated Protein Kinases
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57. The Intersection of Genetics and Epigenetics: Reactivation of Mammalian LINE-1 Retrotransposons by Environmental Injury
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59. Good, Bad, Mobile Elements: Genome's Most Successful “Parasites” as Emerging Players in Cell and Organismal Aging
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60. HIV suppressors against LINE-1: one functions as two
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61. A new system for analyzing LINE retrotransposition in the chicken DT40 cell line widely used for reverse genetics
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62. Cell-host, LINE and environment
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63. LINE-1 retrotransposon activation drives age-associated inflammation via cytoplasmic cDNA-STING/type I interferon signalling: therapeutic potential of reverse transcriptase inhibition
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64. Methylation pattern of retrotransposons: Biomarker for human cancer
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65. LINE-1-Induced Retrotransposition Affects Early Preimplantation Embryo DNA Integrity and Pluripotency
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67. LINE retrotransposition and host DNA repair machinery
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68. Retrotransposons: Genomic and Trans-Genomic Agents of Change
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69. Nutrition, Histone Epigenetic Marks, and Disease
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70. Integrated mechanism for the generation of the 5′ junctions of LINE inserts
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71. Consequences of ongoing retrotransposition in mammalian genomes
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72. Varying recombination landscapes between individuals are driven by polymorphic transposable elements
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74. Dynamic and Ongoing De Novo L1 Retrotransposition Contributes to Genome Plasticity and Intrapatient Heterogeneity in Ovarian Cancer
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