The Human LINE-1 Retrotransposon Creates DNA Double-strand Breaks

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Items 101–200 of 518

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5. Selection against LINE-1 retrotransposons results principally from their ability to mediate ectopic recombination
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7. Poly(A) Binding Protein C1 Is Essential for Efficient L1 Retrotransposition and Affects L1 RNP Formation
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8. Genetic Drift, Not Life History or RNAi, Determine Long-Term Evolution of Transposable Elements
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9. Decreased Dicer expression elicits DNA damage and up-regulation of MICA and MICB
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12. Phosphorylation of ORF1p is required for L1 retrotransposition
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13. The Specificity and Flexibility of L1 Reverse Transcription Priming at Imperfect T-Tracts
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14. The RNA Polymerase Dictates ORF1 Requirement and Timing of LINE and SINE Retrotransposition
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15. Transposable elements as new players in neurodegenerative diseases
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16. Melatonin sensitizes human breast cancer cells to ionizing radiation by downregulating proteins involved in double‐strand DNA break repair
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17. Gtsf1/Cue110, a gene encoding a protein with two copies of a CHHC Zn-finger motif, is involved in spermatogenesis and retrotransposon suppression in murine testes
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18. A LINE-1 component to human aging: Do LINE elements exact a longevity cost for evolutionary advantage?
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19. Characterization of a synthetic human LINE-1 retrotransposon ORFeus-Hs
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22. Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis
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23. Context‐specific regulation of LINE‐1
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24. Potential for genomic instability associated with retrotranspositionally-incompetent L1 loci
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27. Extensive and Biased Intergenomic Nonreciprocal DNA Exchanges Shaped a Nascent Polyploid Genome, Gossypium (Cotton)
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28. Germline Chromothripsis Driven by L1-Mediated Retrotransposition and Alu/Alu Homologous Recombination
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29. Maximizing the ovarian reserve in mice by evading LINE-1 genotoxicity
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30. L1EM: a tool for accurate locus specific LINE-1 RNA quantification
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31. Frequent L1 retrotranspositions originating fromTTC28in colorectal cancer
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32. Replication independent DNA double-strand break retention may prevent genomic instability
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33. L1 retrotransposons exploit RNA m6A modification as an evolutionary driving force
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34. Regulation of L1 expression and retrotransposition by melatonin and its receptor: implications for cancer risk associated with light exposure at night
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37. The Evolutionary Dynamics of Transposable Elements in Eukaryote Genomes
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38. Interplay between RNASEH2 and MOV10 controls LINE-1 retrotransposition
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39. Extracellular vesicles mediate the horizontal transfer of an active LINE‐1 retrotransposon
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41. Enrichment of processed pseudogene transcripts in L1-ribonucleoprotein particles
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42. Long Interspersed Nuclear Element 1 Retrotransposons Become Deregulated during the Development of Ovarian Cancer Precursor Lesions
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43. The L1 retrotransposition assay: A retrospective and toolkit
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44. Transposable elements and psychiatric disorders
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45. Transposons, p53 and Genome Security
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46. LINE-1 activation in the cerebellum drives ataxia
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49. LINE-1: an emerging initiator of cGAS-STING signalling and inflammation that is dysregulated in disease
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53. Asymmetric distribution of parental H3K9me3 in S phase silences L1 elements
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54. Guardian of the Human Genome: Host Defense Mechanisms against LINE-1 Retrotransposition
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56. Retrotransposons as a Source of DNA Damage in Neurodegeneration
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57. LINE-1 ORF-1p functions as a novel androgen receptor co-activator and promotes the growth of human prostatic carcinoma cells
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58. Hypomethylation of long interspersed nuclear element‐1 promoter is associated with poor outcomes for curative resected hepatocellular carcinoma
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59. Long interspersed nuclear element-1 expression and retrotransposition in prostate cancer cells
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63. NOS2 and S -nitrosothiol signaling induces DNA hypomethylation and LINE-1 retrotransposon expression
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93. Different integration site structures between L1 protein-mediated retrotransposition in cis and retrotransposition in trans
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