Solution structure of the Hdm2 C2H2C4 RING, a domain critical for ubiquitination of p53

Kostic, Milka, Matt, Theresia, Martinez-Yamout, Maria A., Dyson, H. Jane, Wright, Peter E.·2006·Journal of Molecular Biology
DOI 10.1016/j.jmb.2006.08.027

Cited by (129)

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  6. Cooperation between MDM2 and MDMX in the Regulation of p53
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  7. Reduced structural rigidity of MDMX protein enhances binding to TP53 mRNA
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  8. Expression levels of MDM2 and MDMX proteins and their associated effects on P53 in human liposarcomas
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  9. Applications of Structural Biology and Bioinformatics in the Investigation of Oxidative Stress-Related Processes
    Beate Bersch, Matthew R. Groves, Johann P. Klare, Andrew E. Torda, Dario Ortiz · 2014 · Springer eBooks
  10. Small molecule inhibitors of Mdm2 E3 ubiquitin ligase activity
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  11. An investigation of the zinc binding characteristics of the RING finger domain from the human RBBP6 protein using heteronuclear NMR spectroscopy.
    Takalani Mulaudzi · 2007 · University of the Western Cape Electronic Theses and Dissertations Repository (University of the Western Cape)
  12. Molecular analysis of the domain with no name (DWNN)/RBBP6 in human cancers
    Zukile Mbita · 2012 · University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)
  13. Characterization of the Ubiquitin/Nedd8 E3 ligase activity of the Mdm2/MdmX complex
    Rajesh Kumar Singh · 2007 · Kölner Universitäts PublikationsServer (Universität zu Köln)
  14. Charakterisierung der biochemischen und biologischen Funktionen von Polyubiquitinketten
    Mathematisch-Naturwissenschaftlichen Sektion · 2010
  15. How do Proteins Work
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  16. Structural and Functional Characterization of the Human Mdm2 and MdmX RING Domains
    Olga Egorova · 2014 · YorkSpace (York University)
  17. Design of a System for Monitoring Ubiquitination Activities of E2 Enzymes Using Engineered RING Finger Proteins
    Kazuhide Miyamoto, Kazuki Saito · 2018 · Methods in molecular biology
  18. An Integrated Structure-based Approach for the Development of MDM2 inhibitors
    Yi Sheng · 2021 · International Electronic Conference on Cancers (IECC)
  19. New insight into the role of MDMX in MDM2-mediated p53 degradation and anti-cancer drug development
    Jing Yang, Yanping Zhang · 2021 · Oncoscience
  20. Kleine Zinkfinger-Proteine in Haloferax volcanii
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  21. References
    2009 · Wiley eBooks
  22. The MDM2 oncoprotein antagonizes Poly(ADP-ribosyl)ation
    Celeste Giansanti · 2023
  23. Data from RING Domain–Mediated Interaction Is a Requirement for MDM2's E3 Ligase Activity
    Hidehiko Kawai, Vanessa Lopez-Pajares, Mihee M. Kim, Dmitri Wiederschain, Zhi-Min Yuan · 2023
  24. Data from RING Domain–Mediated Interaction Is a Requirement for MDM2's E3 Ligase Activity
    Hidehiko Kawai, Vanessa Lopez-Pajares, Mihee M. Kim, Dmitri Wiederschain, Zhi-Min Yuan · 2023
  25. Additional file 1 of MDMX is essential for the regulation of p53 protein levels in the absence of a functional MDM2 C-terminal tail
    Sanford, Jack D., Yang, Jing, Han, Jing, Laura A. Tollini, Aiwen Jin, Zhang, Yanping · 2021 · Figshare
  26. The role of NEDD8 pathway in cell invasion and strategies for the use of NEDD8 inhibitors in the clinic
    Lara J. Bou Malhab · 2016 · theses.fr (ABES)
  27. Computational Analysis of the Homologous Mouse Double RINGs Interface for Targeted Anticancer Drug Design
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  28. BindingDB Entry 50043548: 5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2.
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  29. Investigation of protein-metal ion and protein-protein interactions using mass spectrometry and nuclear magnetic spectroscopy
    Faqeer A. Hassem · 2014 · UWC Research Repository (University of the Western Cape)