Conformational Flexibility and Structural Dynamics in GPCR-Mediated G Protein Activation: A Perspective

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The 2.6 Angstrom Crystal Structure of a Human A 2A Adenosine Receptor Bound to an Antagonist

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Crystal structure of opsin in its G-protein-interacting conformation

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Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

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The Dynamic Process of β2-Adrenergic Receptor Activation

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Crystal Structure of the Catalytic Domains of Adenylyl Cyclase in a Complex with G sα ·GTPγS

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Biased Signaling Pathways in β 2 -Adrenergic Receptor Characterized by 19 F-NMR

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Crystal structure of metarhodopsin II

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Activation mechanism of the β 2 -adrenergic receptor

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Activation of the β2-Adrenergic Receptor Involves Disruption of an Ionic Lock between the Cytoplasmic Ends of Transmembrane Segments 3 and 6

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The structural basis of agonist-induced activation in constitutively active rhodopsin

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The Highly Conserved DRY Motif of Class A G Protein-Coupled Receptors: Beyond the Ground State

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Conformational changes in the G protein Gs induced by the β2 adrenergic receptor

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Identification of two distinct inactive conformations of the β 2 -adrenergic receptor reconciles structural and biochemical observations

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Hydrophobic amino acid in the i2 loop plays a key role in receptor-G protein coupling.

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A Lipid Pathway for Ligand Binding Is Necessary for a Cannabinoid G Protein-coupled Receptor

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Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins

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Critical Role for the Second Extracellular Loop in the Binding of Both Orthosteric and Allosteric G Protein-coupled Receptor Ligands

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Cholesterol increases kinetic, energetic, and mechanical stability of the human β 2 -adrenergic receptor

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Internal Hydration Increases during Activation of the G-Protein-Coupled Receptor Rhodopsin

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Ligand-Dependent Perturbation of the Conformational Ensemble for the GPCR β2 Adrenergic Receptor Revealed by HDX

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Evaluating Cellular Impedance Assays for Detection of GPCR Pleiotropic Signaling and Functional Selectivity

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Gα Minigenes Expressing C-terminal Peptides Serve as Specific Inhibitors of Thrombin-mediated Endothelial Activation

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Ligand-Specific Interactions Modulate Kinetic, Energetic, and Mechanical Properties of the Human β2 Adrenergic Receptor

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Recent progress in the study of G protein-coupled receptors with molecular dynamics computer simulations

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Disease-causing Mutation in GPR54 Reveals the Importance of the Second Intracellular Loop for Class A G-protein-coupled Receptor Function

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Conformational Dynamics of Activation for the Pentameric Complex of Dimeric G Protein-Coupled Receptor and Heterotrimeric G Protein

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Concerted Interconversion between Ionic Lock Substates of the β2 Adrenergic Receptor Revealed by Microsecond Timescale Molecular Dynamics

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Structural determinants in the second intracellular loop of the human cannabinoid CB1receptor mediate selective coupling to Gsand Gi

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Rapid Activation of Transducin by Mutations Distant from the Nucleotide-binding Site

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Impact of the DRY Motif and the Missing “Ionic Lock” on Constitutive Activity and G-Protein Coupling of the Human Histamine H4 Receptor

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Single Amino Acid Substitutions and Deletions That Alter the G Protein Coupling Properties of the V2 Vasopressin Receptor Identified in Yeast by Receptor Random Mutagenesis

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The Receptor-Bound “Empty Pocket” State of the Heterotrimeric G-Protein α-Subunit Is Conformationally Dynamic

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The Nucleotide Exchange Factor Ric-8A Is a Chaperone for the Conformationally Dynamic Nucleotide-Free State of Gαi1

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Disruption of the α5 Helix of Transducin Impairs Rhodopsin-Catalyzed Nucleotide Exchange

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A Novel Site on the Gα-protein That Recognizes Heptahelical Receptors

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Two Amino Acids within the α4 Helix of Gαi1Mediate Coupling with 5-Hydroxytryptamine1BReceptors

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Molecular Dynamics Simulations of the Adenosine A2a Receptor: Structural Stability, Sampling, and Convergence

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Structural Evidence for a Sequential Release Mechanism for Activation of Heterotrimeric G Proteins

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Molecular Dynamics Simulations of Transducin: Interdomain and Front to Back Communication in Activation and Nucleotide Exchange

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Dynamic Structure of Retinylidene Ligand of Rhodopsin Probed by Molecular Simulations

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Conformational Changes Associated with Receptor-stimulated Guanine Nucleotide Exchange in a Heterotrimeric G-protein α-Subunit

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Molecular simulations and solid-state NMR investigate dynamical structure in rhodopsin activation

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Agonist Dynamics and Conformational Selection during Microsecond Simulations of the A2A Adenosine Receptor

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Predictions for Cholesterol Interaction Sites on the A2A Adenosine Receptor

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