The DOI matches its Crossref record; 162 of the 162 references it cites were found in a registry or an index.
Peptide Design Principles for Antimicrobial Applications
Open accessAbstract
The increased incidence of bacterial resistance to available antibiotics represents a major global health problem and highlights the need for novel anti-infective therapies. Antimicrobial peptides (AMPs) represent promising alternatives to conventional antibiotics. AMPs are versatile, have almost unlimited sequence space, and can be tuned for broad-spectrum or specific activity against microorganisms. However, several obstacles remain to be overcome in order to develop AMPs for medical use, such as toxicity, stability, and bacterial resistance. We lack standard experimental procedures for quantifying AMP activity and do not yet have a clear picture of the mechanisms of action of AMPs. The rational design of AMPs can help solve these issues and enable their use as new antimicrobials. Here we provide an overview of the main physicochemical features that can be engineered to achieve enhanced bioactivity and describe current strategies being used to design AMPs.
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Cites
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Cited by
Therapeutic Peptides: Current Applications and Future Directions
Wang, L., Wang, N., Zhang, W., Cheng, X., Yan, Z., Shao, G., Wang, X., Wang, R., & Fu, C. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00904-4 · Cited by 2,131
Antimicrobial host defence peptides: functions and clinical potential
Mookherjee, N., Anderson, M. A., Haagsman, H. P., & Davidson, D. J. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0058-8 · Cited by 1,502
Accelerating antibiotic discovery through artificial intelligence
Melo, M. C. R., Maasch, J. R. M. A., & de la Fuente-Nunez, C. (2021) · Communications Biology · doi:10.1038/s42003-021-02586-0 · Cited by 234
Self-citationBiofilm and wound healing: from bench to bedside
Goswami, A. G., Basu, S., Banerjee, T., & Shukla, V. K. (2023) · European Journal of Medical Research · doi:10.1186/s40001-023-01121-7 · Cited by 178
Lima, P. G., Oliveira, J. T. A., Amaral, J. L., Freitas, C. D. T., & Souza, P. F. N. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119647 · Cited by 170
Metadata
- Authors
- Torres, M. D. T., Sothiselvam, S., Lu, T. K., & de la Fuente-Nunez, C.
- Venue
- Journal of Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2019-08
- Volume
- 431
- Issue
- 18
- Pages
- 3547-3567
- ISSN
- 0022-2836 (ISSN-L)
- OpenAlex
- W2906960763
- Cited by
- 438
- References
- 162
- FWCI
- 33.07
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Torres, M. D. T., Sothiselvam, S., Lu, T. K., & de la Fuente-Nunez, C. (2019). Peptide Design Principles for Antimicrobial Applications. Journal of Molecular Biology. https://doi.org/10.1016/j.jmb.2018.12.015
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
