Comparative Study of the Neuropeptide-Y Sympathetic Nerves in Endometriotic Involved and Noninvolved Sacrouterine Ligaments in Women with Pelvic Endometriosis
Abstract
Study objective To show the relationship between the neuropeptide-Y pelvic sympathetic nerves and neoangiogenesis in the development of endometriosis Design Prospective study. Setting Academic community teaching hospital. Patients Fifteen consecutive women with unilateral endometriotic infiltration of the sacrouterine ligaments. Interventions A laparoscopic excision/biopsy of involved and noninvolved parts of the sacrouterine ligaments were taken. The sections were incubated with the neuronal marker rabbit polyclonal anti-protein gene product 9.5 and rabbit polyclonal anti-neuropeptide-Y. We made a comparative study on the distribution of nerve fibers and their relationship to the vessels on intact and endometriotic involved tissue. Measurements and main results The results show that a large amount of nerves are present around the blood vessels in the endometriosis samples, and a large number of these nerves are neuropeptide-Y sympathetic nerves. Adrenergic fibers are also present in the intact control subjects, however, in significantly smaller amounts. Conclusion This finding shows a strong relationship between the neuropeptide-Y sympathetic pelvic nerves and the neoangiogenesis required for the development of endometriosis.
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In women, sympathetic fibers are strongly associated with blood vessels in endometriosis lesions that infiltrate uterosacral ligaments.
“Possover et al. (2009) found a strong association between sympathetic fibers and blood vessels in endometriosis lesions infiltrating uterosacral ligaments.”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Possover et al., 2009
That study did not assess whether the sympathetic fiber-blood vessel association correlated with patients' symptoms.
“However, correlation with patients' symptoms was not assessed.”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Possover et al., 2009
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- Authors
- Possover, M., Tersiev, P., & Angelov, D. N.
- Affiliations
- Klinik Hirslanden (CH)
- University of Cologne (DE)
- Corresponding author
- Possover, Marc
- Venue
- Journal of Minimally Invasive Gynecology
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 16
- Issue
- 3
- Pages
- 340-343
- ISSN
- 1553-4650 (ISSN-L)
- OpenAlex
- W2004594724
- Cited by
- 11
- References
- 23
- Citations by year
- 2026: 1 · 2024: 2 · 2021: 2 · 2020: 1 · 2016: 1 · 2015: 1 · 2012: 1
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Minimally Invasive Gynecology (publishedVersion)
- PubMed (publishedVersion)
- BORIS (University Library Bern) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Plant and fungal interactions
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- pelvic endometriosis, neuropeptide Y, sympathetic nerves, neoangiogenesis, adrenergic fibers, protein gene product 9.5
- MeSH terms
- Adult, Biopsy, Endometriosis, Female, Humans, Ligaments, Neovascularization, Pathologic, Neuropeptide Y, Prospective Studies, Sympathetic Nervous System, Pelvic Pain, Young Adult
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