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Cited by 12Characterization and Applications of Magnetic NanoparticlesNanoparticle-Based Drug DeliveryParticle Dynamics in Fluid Flows

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Simulation and experimental validation of magnetic nanoparticle accumulation in a bloodstream mimicking flow system

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Reinelt, Magdalena, Ahlfs, Johannes, Stein, Rene, Alexiou, Christoph, Bänsch, Eberhard, Friedrich, Ralf P., Lyer, Stefan, Neuss-Radu, Maria, Neuß, Nicolas·2023·Journal of Magnetism and Magnetic Materials
DOI 10.1016/j.jmmm.2023.170984
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Abstract

In this paper, a mathematical model for the dynamics of superparamagnetic iron oxide nanoparticles (SPIONs) in a laminar flow through a pipe under the influence of an external magnetic field of a single electromagnet is derived. The model consists of a convection–diffusion equation coupled with magnetostatic equations. The accumulation of particles along the boundary is modeled with the help of a surface concentration. Based on experimental data describing the retention of lauric acid coated SPIONs in a tubular flow under the influence of a magnetic field, the model is parametrized and finite element simulations are performed. With the exception of one outlier at low SPION concentration and high flowspeed, the simulation results agree very well with the experimental measurements within the bounds of the measurement error.

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Metadata

Authors
Reinelt, M., Ahlfs, J., Stein, R., Alexiou, C., Bänsch, E., Friedrich, R. P., Lyer, S., Neuss-Radu, M., & Neuß, N.
Affiliations
Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
Corresponding author
Neuß, Nicolas
ORCID
Venue
Journal of Magnetism and Magnetic Materials
Publisher
Elsevier BV
Published
2023-09
Volume
582
Pages
170984
ISSN
0304-8853 (ISSN-L)
DOI
10.1016/j.jmmm.2023.170984
OpenAlex
W4382983135
Cited by
12
References
0
Citations by year
2026: 3 · 2025: 5 · 2024: 4
FWCI
0.95
Type
journal article
Language
en
Open access
Licence
Locations
Journal of Magnetism and Magnetic Materials (publishedVersion, cc-by)
Funders
Forschungsstiftung Medizin am Universitätsklinikum Erlangen
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Chemical Engineering › Fluid Flow and Transfer Processes › Particle Dynamics in Fluid Flows
Keywords
superparamagnetic iron oxide nanoparticles, magnetohydrodynamics, advection-diffusion equation, magnetostatics, laminar pipe flow, external magnetic field, surface concentration, nanoparticle retention, finite element analysis, model validation

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