Efficient drug-delivery using magnetic nanoparticles — biodistribution and therapeutic effects in tumour bearing rabbits
Abstract
To treat tumours efficiently and spare normal tissues, targeted drug delivery is a promising alternative to conventional, systemic administered chemotherapy. Drug-carrying magnetic nanoparticles can be concentrated in tumours by external magnetic fields, preventing the nanomaterial from being cleared by metabolic burden before reaching the tumour. Therefore in Magnetic Drug Targeting (MDT) the favoured mode of application is believed to be intra-arterial. Here, we show that a simple yet versatile magnetic carrier-system (hydrodynamic particles diameter From the clinical editor This team of investigators studied drug carrying nanoparticles for magnetic drug targeting (MDT), demonstrating the importance of intra-arterial administration resulting in improved clinical outcomes in the studied animal model compared with intra-venous.
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SPIONs are biocompatible.
“Moreover, SPIONs are biocompatible [2,6].”
From Experimental and Simulative Analysis of Magnetic Nanoparticle Accumulation Using Various Halbach Arrays (2024) · cites this paper as [6]
Cites
Noninvasive detection of clinically occult lymph-node metastases in prostate cancer
Harisinghani, M. G., Barentsz, J., Hahn, P. F., Deserno, W. M., Tabatabaei, S., van de Kaa, C. H., de la Rosette, J., & Weissleder, R. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022749 · Cited by 1,971 · see citing works
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Iron Oxide Nanoparticles for Magnetically-Guided and Magnetically-Responsive Drug Delivery
Estelrich, J., Escribano, E., Queralt, J., & Busquets, M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16048070 · Cited by 532 · see citing works
The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors
Izci, M., Maksoudian, C., Manshian, B. B., & Soenen, S. J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00779 · Cited by 506 · see citing works
Magnetic nanoparticle-based drug delivery for cancer therapy
Tietze, R., Zaloga, J., Unterweger, H., Lyer, S., Friedrich, R. P., Janko, C., Pöttler, M., Dürr, S., & Alexiou, C. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.08.022 · Cited by 425 · see citing works
Self-citationEndothelial biocompatibility and accumulation of SPION under flow conditions
Matuszak, J., Zaloga, J., Friedrich, R. P., Lyer, S., Nowak, J., Odenbach, S., Alexiou, C., & Cicha, I. (2015) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2014.09.005 · Cited by 24 · see citing works
Self-citationThalmayer, A. S., Götz, K., Lübke, M., & Fischer, G. (2024) · Current Directions in Biomedical Engineering · doi:10.1515/cdbme-2024-2159
- Authors
- Tietze, R., Lyer, S., Dürr, S., Struffert, T., Engelhorn, T., Schwarz, M., Eckert, E., Göen, T., Vasylyev, S., Peukert, W., Wiekhorst, F., Trahms, L., Dörfler, A., & Alexiou, C.
- Affiliations
- Universitätsklinikum Erlangen (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Physikalisch-Technische Bundesanstalt (DE)
- Corresponding author
- Alexiou, Christoph
- ORCID
- Venue
- Nanomedicine: Nanotechnology, Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 9
- Issue
- 7
- Pages
- 961-971
- ISSN
- 1549-9634 (ISSN-L)
- OpenAlex
- W1980264362
- Cited by
- 232
- References
- 1
- Citations by year
- 2026: 9 · 2025: 17 · 2024: 12 · 2023: 23 · 2022: 24 · 2021: 19 · 2020: 17 · 2019: 13 · 2018: 15 · 2017: 20 · 2016: 22 · 2015: 28 · 2014: 13
- FWCI
- 7.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nanomedicine Nanotechnology Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Keywords
- magnetic drug delivery, magnetic nanoparticles, targeted drug delivery, mitoxantrone, intra-arterial administration, tumor remission, survival, chemotherapy
- MeSH terms
- Animals, Female, Mitoxantrone, Neoplasms, Particle Size, Rabbits, Radiography, Spectrophotometry, Infrared, Tissue Distribution, Drug Delivery Systems, Magnetite Nanoparticles
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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