The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model
Abstract
The endovascular perforation rodent model for experimental subarachnoid hemorrhage (SAH) studies is criticized for lack of control over bleeding. Presently, there is no practical grading system to categorize the severity of SAH depending on the amount of blood. We outline a simple and objective novel SAH grading system by examining the subarachnoid blood clots in the basal cisterns, and evaluate for correlation with neurological status and cerebral vasospasm. Effects of simvastatin, known to reduce vasospasm, were examined using this grading system. Seventy-seven adult male Sprague-Dawley rats were divided randomly into three groups: sham-operated (n=24), SAH (n=32), and SAH+simvastatin (n=25). High-resolution brain pictures were used to grade the severity of SAH and categorize animals into mild, moderate and severe groups. The SAH grades were compared with neurological scores and internal carotid artery parameters such as diameter, perimeter and wall thickness at 24h. Two investigators verified the grading system independently. The SAH grade showed linear correlation functionally with neurological status (r=0.42, p 0.7, p<0.01), and also between two independent investigators (r=0.937, p<0.001). Simvastatin improved neurological score in moderate and severe (p<0.05) but not mild SAH groups (p=0.28). This grading system has the potential to be adopted for SAH experimental rodent models.
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“was carried out by two investigators who were blind to the experiments [28].”
From CX3CL1/CX3CR1 axis attenuates early brain injury via promoting the delivery of exosomal microRNA-124 from neuron to microglia after subarachnoid hemorrhage (2020) · cites this paper as [28]
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Cited by
Cao, S., Shrestha, S., Li, J., Yu, X., Chen, J., Yan, F., Ying, G., Gu, C., Wang, L., & Chen, G. (2017) · Scientific Reports · doi:10.1038/s41598-017-02679-z · Cited by 152
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Metadata
- Authors
- Sugawara, T., Ayer, R., Jadhav, V., & Zhang, J. H.
- Venue
- Journal of Neuroscience Methods
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 167
- Issue
- 2
- Pages
- 327-334
- ISSN
- 0165-0270
- Cited by
- 569
- References
- 18
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
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