CX3CL1/CX3CR1 axis attenuates early brain injury via promoting the delivery of exosomal microRNA-124 from neuron to microglia after subarachnoid hemorrhage
Open accessAbstract
Background: Microglial activation-mediated neuroinflammation is a major contributor to early brain injury (EBI) after subarachnoid hemorrhage (SAH). MicroRNA-124 (miR-124) is the most abundant miRNAs in the central nervous system (CNS) and plays a vital role in microglial activation by targeting protein CCAAT-enhancer-binding protein α (C/EBPα). It has been reported that the CX3CL1/CX3CR1 axis is involved in the delivery of miR-124 from neurons to microglia. Methods: An experimental rat SAH model was established by injecting autologous arterial blood into the prechiasmatic cistern, and cultured primary neurons and microglia were exposed to oxyhemoglobin to mimic SAH in vitro. We additionally exploited specific expression plasmids encoding CX3CL1 and CX3CR1. Results: We observed significant decreases in CX3CL1 and CX3CR1 in the brain tissues of SAH patients. We also observed decreases in the levels of CX3CL1 in neurons and CX3CR1 in microglia after SAH in rats. Moreover, microglia exhibited an activated phenotype with macrophage-like morphology and high levels of CD45 and major histocompatibility complex (MHC) class II after SAH. After overexpression of CX3CL1/CX3CR1, the level of CD45 and MHC class II and the release of inflammatory factors tumor necrosis factor α, interleukin 1α and complement 1q were significantly decreased. There was also increased neuronal degeneration and behavior dysfunction after SAH, both of which were inhibited by CX3CL1/CX3CR1 overexpression. Additionally, we found that the delivery of exosomal miR-124 from neurons to microglia was significantly reduced after SAH, accompanied by an increase in C/EBPα expression, and was inhibited by CX3CL1/CX3CR1 overexpression. In conclusion, the CX3CL1/CX3CR1 axis may play protective roles after SAH by promoting the delivery of exosomal miR-124 to microglia and attenuate microglial activation and neuroinflammation. Conclusions: CX3CL1/CX3CR1 axis may be a potential intervention target for the inhibition of SAH-induced EBI by promoting exosome transport of miR-124 to microglia.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Doyle, L. M., & Wang, M. Z. (2019) · Cells · doi:10.3390/cells8070727 · Cited by 3,271 · see citing works
Reactive Astrocytes: Production, Function, and Therapeutic Potential
Liddelow, S. A., & Barres, B. A. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.006 · Cited by 2,336 · see citing works
Control of microglial neurotoxicity by the fractalkine receptor
Cardona, A. E., Pioro, E. P., Sasse, M. E., Kostenko, V., Cardona, S. M., Dijkstra, I. M., Huang, D., Kidd, G., Dombrowski, S., Dutta, R., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1715 · Cited by 1,531 · see citing works
Harrison, J. K., Jiang, Y., Chen, S., Xia, Y., Maciejewski, D., McNamara, R. K., Streit, W. J., Salafranca, M. N., Adhikari, S., Thompson, D. A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10896 · Cited by 1,176 · see citing works
Exosomes: secreted vesicles and intercellular communications
Théry, C. (2011) · F1000 Biology Reports · doi:10.3410/b3-15 · Cited by 989 · see citing works
Cheng, L., Sharples, R. A., Scicluna, B. J., & Hill, A. F. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.23743 · Cited by 840 · see citing works
Ponomarev, E. D., Veremeyko, T., Barteneva, N., Krichevsky, A. M., & Weiner, H. L. (2011) · Nature Medicine · doi:10.1038/nm.2266 · Cited by 787 · see citing works
Sugawara, T., Ayer, R. E., Jadhav, V. R., & Zhang, J. H. (2007) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2007.08.004 · Cited by 602 · see citing works
Sublime Microglia: Expanding Roles for the Guardians of the CNS
Salter, M. W., & Beggs, S. (2014) · Cell · doi:10.1016/j.cell.2014.06.008 · Cited by 531 · see citing works
Essandoh, K., Yang, L., Wang, X., Huang, W. C., Qin, D., Hao, J., Wang, Y., Zingarelli, B., Peng, T., & Fan, G. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.08.010 · Cited by 435 · see citing works
Self-citationMicroglial cell activation and proliferation precedes the onset of CNS autoimmunity
Ponomarev, E. D., Shriver, L. P., Maresz, K., & Dittel, B. N. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20488 · Cited by 349 · see citing works
Fang, J., Zhang, Z., Shang, L., Luo, Y., Lin, Y., Yuan, Y., & Zhuang, S. (2018) · Hepatology · doi:10.1002/hep.29920 · Cited by 335 · see citing works
The Multifaceted Profile of Activated Microglia
Lynch, M. A. (2009) · Molecular Neurobiology · doi:10.1007/s12035-009-8077-9 · Cited by 323 · see citing works
Ponomarev, E. D., Veremeyko, T., & Weiner, H. L. (2012) · Glia · doi:10.1002/glia.22363 · Cited by 311 · see citing works
Pullen, T. J., Xavier, G. D. S., Kelsey, G., & Rutter, G. A. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01433-10 · Cited by 264 · see citing works
Yang, Y., Ye, Y., Kong, C., Su, X., Zhang, X., Bai, W., & He, X. (2019) · Neurochemical Research · doi:10.1007/s11064-018-02714-z · Cited by 199 · see citing works
MiRNA-124 induces neuroprotection and functional improvement after focal cerebral ischemia
Taj, S. H., Kho, W., Riou, A., Wiedermann, D., & Hoehn, M. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.03.025 · Cited by 191 · see citing works
CX3CL1 Is Neuroprotective in Permanent Focal Cerebral Ischemia in Rodents
Cipriani, R., Villa, P., Chece, G., Lauro, C., Paladini, A., Micotti, E., Perego, C., Simoni, M. G. D., Fredholm, B. B., Eusebi, F., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3611-11.2011 · Cited by 189 · see citing works
Axo-myelinic neurotransmission: a novel mode of cell signalling in the central nervous system
Micu, I., Plemel, J. R., Caprariello, A. V., Nave, K., & Stys, P. K. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.128 · Cited by 162 · see citing works
Zusso, M., Methot, L., Lo, R., Greenhalgh, A. D., David, S., & Stifani, S. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6182-11.2012 · Cited by 154 · see citing works
MiR-9 promotes microglial activation by targeting MCPIP1
Yao, H., Ma, R., Yang, L., Hu, G., Chen, X., Duan, M., Kook, Y., Niu, F., Liao, K., Fu, M., et al. (2014) · Nature Communications · doi:10.1038/ncomms5386 · Cited by 146 · see citing works
Self-citationNeuroinflammation and fractalkine signaling in Alzheimer’s disease
Finneran, D. J., & Nash, K. R. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1412-9 · Cited by 133 · see citing works
Opposing Effects of Membrane-Anchored CX3CL1 on Amyloid and Tau Pathologies via the p38 MAPK Pathway
Lee, S., Xu, G., Jay, T. R., Bhatta, S., Kim, K.-W., Jung, S., Landreth, G. E., Ransohoff, R. M., & Lamb, B. T. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.0853-14.2014 · Cited by 123 · see citing works
Role of Exosomes as a Treatment and Potential Biomarker for Stroke
Otero‐Ortega, L., Laso-García, F., Frutos, M. G.-D., Fuentes, B., Diekhorst, L., Díez‐Tejedor, E., & Gutiérrez‐Fernández, M. (2018) · Translational Stroke Research · doi:10.1007/s12975-018-0654-7 · Cited by 122 · see citing works
Yu, A., Zhang, T., Duan, H., Pan, Y., Zhang, X., Yang, G., Wang, J., Deng, Y., & Yang, Z. (2016) · Immunology Letters · doi:10.1016/j.imlet.2016.12.003 · Cited by 121 · see citing works
Microglia and inflammation: conspiracy, controversy or control?
Fernandes, A. M. A., Miller‐Fleming, L., & Pais, T. F. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1670-8 · Cited by 110 · see citing works
Zheng, Z. V., Lyu, H., Lam, S. Y. E., Lam, P. K., Poon, W. S., & Wong, G. K. C. (2019) · Translational Stroke Research · doi:10.1007/s12975-019-00728-5 · Cited by 109 · see citing works
Poniatowski, Ł. A., Wojdasiewicz, P., Krawczyk, M., Szukiewicz, D., Gasik, R., Kubaszewski, Ł., & Kurkowska‐Jastrzębska, I. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9787-4 · Cited by 102 · see citing works
Liu, W., Li, R., Yin, J., Guo, S., Chen, Y., Fan, H., Li, G., Li, Z., Li, X., Zhang, X., et al. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1396-5 · Cited by 102 · see citing works
Self-citationZuo, Y., Huang, L., Enkhjargal, B., Xu, W., Ocak, U., Travis, Z. D., Zhang, G., Tang, J., Liu, F., & Zhang, J. H. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1432-5 · Cited by 101 · see citing works
Tan, J., Town, T., & MULLAN, M. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002006200 · Cited by 93 · see citing works
TFEB activation protects against cardiac proteotoxicity via increasing autophagic flux
Pan, B., Zhang, H., Cui, T., & Wang, X. (2017) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2017.10.003 · Cited by 93 · see citing works
Fractalkine/CX3CR1 is involved in the cross-talk between neuron and glia in neurological diseases.
Luo, P., Chu, S.-F., Zhang, Z., Xia, C.-Y., & Chen, N.-H. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.11.017 · Cited by 85 · see citing works
Liu, Y., Wu, X., Luo, Q., Huang, S., Yang, Q., Wang, F.-X., Ke, Y., & Qian, Z. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.97 · Cited by 83 · see citing works
Effect of Inflammation on the Process of Stroke Rehabilitation and Poststroke Depression
Fang, M.-D., Zhong, L., Jin, X., Cui, R., Yang, W., Gao, S., Lv, J., Li, B., & Liu, T. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00184 · Cited by 78 · see citing works
Deng, Y., He, H., Ren, L., & Guo, T. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.244793 · Cited by 75 · see citing works
Venkat, P., Chen, J., & Chopp, M. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18782789 · Cited by 71 · see citing works
Zhang, H., Pan, B., Wu, P., Parajuli, N., Rekhter, M. D., Goldberg, A. L., & Wang, X. (2019) · Science Advances · doi:10.1126/sciadv.aaw5870 · Cited by 71 · see citing works
Zhang, J., Liu, Y., Liu, X., Li, S., Cheng, C., Chen, S., & Le, W. (2018) · Translational Neurodegeneration · doi:10.1186/s40035-018-0138-4 · Cited by 65 · see citing works
Pan, B., Yang, L., Wang, J., Wang, Y., Wang, J., Zhou, X., Yin, X., Zhang, Z., & Zhao, D. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8646-4 · Cited by 61 · see citing works
Self-citationKäufer, C., Chhatbar, C., Bröer, S., Waltl, I., Ghita, L., Gerhauser, I., Kalinke, U., & Löscher, W. (2018) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1806754115 · Cited by 61 · see citing works
Zhao, C., Ma, J., Wang, Z., Li, H., Shen, H., Li, X., & Chen, G. (2020) · Translational Stroke Research · doi:10.1007/s12975-019-00775-y · Cited by 60 · see citing works
Self-citationCheng, X., Ander, B. P., Jickling, G. C., Zhan, X., Hull, H., Sharp, F. R., & Stamova, B. S. (2019) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x19839501 · Cited by 58 · see citing works
Wan, W., Ding, Y. P., Xie, Z., Li, Q., Yan, F., Enkhjargal, B., Pearce, W. J., Hartman, R. E., Obenaus, A., Zhang, J. H., et al. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18760954 · Cited by 51 · see citing works
HMGB1 promotes neurovascular remodeling via Rage in the late phase of subarachnoid hemorrhage
Tian, X., Sun, L., Feng, D., Sun, Q., Dou, Y., Liu, C., Zhou, F., Li, H., Shen, H., Wang, Z., et al. (2017) · Brain Research · doi:10.1016/j.brainres.2017.06.001 · Cited by 42 · see citing works
Self-citationInflammation: a Good Research Target to Improve Outcomes of Poor-Grade Subarachnoid Hemorrhage
Suzuki, H. (2019) · Translational Stroke Research · doi:10.1007/s12975-019-00713-y · Cited by 42 · see citing works
STI571 protects neuronal cells from neurotoxic prion protein fragment-induced apoptosis
Yao-qian, P., Sun, L., Wang, J., Fu, W., Fu, Y., Wang, J., Tong, Y., & Pan, B. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.01.029 · Cited by 40 · see citing works
Modulation and Evolution of Animal Development through microRNA Regulation of Gene Expression
Kittelmann, S., & McGregor, A. P. (2019) · Genes · doi:10.3390/genes10040321 · Cited by 40 · see citing works
Dysregulation and Diagnostic Potential of microRNA in Alzheimer’s Disease
Pan, Y., Liu, R., Terpstra, E. J. M., Wang, Y., Qiao, F., Wang, J., Tong, Y., & Pan, B. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150451 · Cited by 38 · see citing works
Self-citationPandur, E., Tamási, K., Pap, R., Varga, E., Miseta, A., & Sipos, K. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-019-00694-4 · Cited by 38 · see citing works
CNS-Wide over Expression of Fractalkine Improves Cognitive Functioning in a Tauopathy Model
Finneran, D. J., Morgan, D., Gordon, M. N., & Nash, K. R. (2018) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-018-9822-5 · Cited by 36 · see citing works
Micu, I., Plemel, J. R., Caprariello, A. V., Nave, K., & Stys, P. K. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.166 · Cited by 36 · see citing works
McMillin, M., Grant, S. M., Frampton, G. A., Petrescu, A. D., Williams, E., Jefferson, B., Thomas, A., Brahmaroutu, A., & DeMorrow, S. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1455-y · Cited by 33 · see citing works
Li, X., Li, J., Qian, J., Zhang, D., Shen, H., Li, X., Li, H., & Chen, G. (2018) · Stroke · doi:10.1161/strokeaha.118.022404 · Cited by 31 · see citing works
Self-citationWang, Y., Zhao, D., Pan, B., Song, Z., Shah, S. Z. A., Yin, X., Zhou, X., & Yang, L. (2015) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0562-1 · Cited by 29 · see citing works
Self-citationLong-term impairment of neurovascular coupling following experimental subarachnoid hemorrhage
Balbi, M., Vega, M. J., Lourbopoulos, A. I., Terpolilli, N. A., & Plesnila, N. (2019) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x19863021 · Cited by 29 · see citing works
Fu, L. N., Shi, J., Liu, A., Zhou, L., Jiang, M., Fu, H., Xu, K., Li, D., Deng, A., Zhang, Q., et al. (2016) · International Journal of Cancer · doi:10.1002/ijc.30481 · Cited by 28 · see citing works
Self-citationWang, J., Zhao, D., Pan, B., Fu, Y., Shi, F., Kouadir, M., Yang, L., Yin, X., & Zhou, X. (2014) · Journal of Molecular Neuroscience · doi:10.1007/s12031-014-0442-0 · Cited by 26 · see citing works
Feng, Z., Ye, L., Klebe, D. W., Ding, Y. P., Guo, Z., Flores, J. J., Yin, C., Tang, J., & Zhang, J. H. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17725211 · Cited by 25 · see citing works
Experimental Aneurysmal Subarachnoid Hemorrhage: Tiding Over
Kamp, M. A., Steiger, H., & van Lieshout, J. H. (2019) · Translational Stroke Research · doi:10.1007/s12975-019-00726-7 · Cited by 23 · see citing works
microRNA-367-3p regulation of GPRC5A is suppressed in ischemic stroke
Tabet, F., Lee, S., Zhu, W., Levin, M. G., Toth, C. L., Torres, L., Vinh, A., Kim, H. A., Chu, H. X., Evans, M. A., et al. (2019) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x19858637 · Cited by 19 · see citing works
Ejarque‐Ortiz, A., Tusell, J. M., Serratosa, J., & Saura, J. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21195 · Cited by 18 · see citing works
Erratum: The nano-architecture of the axonal cytoskeleton
Leterrier, C., Dubey, P., & Roy, S. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.147 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Solar, P., Zamani, A., Lakatosová, K., & Joukal, M. (2022) · Fluids and Barriers of the CNS · doi:10.1186/s12987-022-00312-4 · Cited by 99 · see citing works
The link between neuroinflammation and the neurovascular unit in synucleinopathies
Wang, Q., Zheng, J., Pettersson, S., Reynolds, R., & Tan, E.-K. (2023) · Science Advances · doi:10.1126/sciadv.abq1141 · Cited by 81 · see citing works
Wong, G. C., Chen, J., Zheng, Z., Lü, G., Chan, W., & Zhang, Y. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.330589 · Cited by 67 · see citing works
Self-citationMicroRNA-124: A Key Player in Microglia-Mediated Inflammation in Neurological Diseases
Zhao, J., He, Z., & Wang, J. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.771898 · Cited by 66 · see citing works
Liang, X., Fa, W., Wang, N., Peng, Y., Liu, C., Zhu, M., Tian, N., Wang, Y., Han, X., Qiu, C., et al. (2022) · Aging Cell · doi:10.1111/acel.13748 · Cited by 59 · see citing works
Self-citationCrosstalk between Microglia and Neurons in Neurotrauma: An Overview of the Underlying Mechanisms
Shaito, A. A., Kobeissy, F. H., Haidar, M. A., Ibeh, S., Shakkour, Z., Reslan, M. A., Nwaiwu, J. I., Moqidem, Y. A., Sader, G., Nickles, R. G., et al. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666211202123322 · Cited by 50 · see citing works
Chen, X., He, X., Xu, F., Xu, N., Sharifi, N. H., Zhang, P., Flores, J. J., Wu, L., He, Q., Kanamaru, H., et al. (2023) · Stroke · doi:10.1161/strokeaha.123.043005 · Cited by 50 · see citing works
Self-citationExtracellular vesicles (exosomes and ectosomes) play key roles in the pathology of brain diseases
Meldolesi, J. (2021) · Molecular Biomedicine · doi:10.1186/s43556-021-00040-5 · Cited by 47 · see citing works
Packer, J. M., Bray, C. E., Beckman, N. B., Wangler, L. M., Davis, A. C., Goodman, E. J., Klingele, N. E., & Godbout, J. P. (2023) · Glia · doi:10.1002/glia.24475 · Cited by 45 · see citing works
The Role of the Blood Neutrophil-to-Lymphocyte Ratio in Aneurysmal Subarachnoid Hemorrhage
Cai, L., Zeng, H., Tan, X., Wu, X., Qian, C., & Chen, G. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.671098 · Cited by 44 · see citing works
Self-citationZou, Y., Liao, L., Dai, J., Mazhar, M., Yang, G., Wang, H., Dechsupa, N., & Wang, L. (2023) · Regenerative Therapy · doi:10.1016/j.reth.2023.01.006 · Cited by 40 · see citing works
Zhu, J., Chen, Y., Ji, J., Wang, L., Xie, G., Tang, Z., Qu, X., Liu, Z., & Ren, G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.968520 · Cited by 39 · see citing works
Lin, S., Dai, Y., Han, C., Han, T., Zhao, L., Wu, R., Liu, J., Zhang, B., Huang, N., Liu, Y., et al. (2024) · Genome Medicine · doi:10.1186/s13073-024-01325-4 · Cited by 39 · see citing works
Self-citationThe regulatory roles of microRNAs toward pathogenesis and treatments in Huntington's disease
Tung, C.-W., Huang, P.-Y., Chan, S. C., Cheng, P., & Yang, S. (2021) · Journal of Biomedical Science · doi:10.1186/s12929-021-00755-1 · Cited by 37 · see citing works
The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage
Ning, W., Lv, S., Wang, Q., & Xu, Y. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00241 · Cited by 33 · see citing works
Wang, P., Xue, Y., Zuo, Y., Xue, Y., Zhang, J. H., Duan, J., Liu, F., & Liu, A. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03007-x · Cited by 32 · see citing works
MicroRNAs: a symphony orchestrating evolution and disease dynamics
Quah, S., Subramanian, G., Tan, J. S. L., Utami, K. H., & Sampath, P. (2025) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2024.07.004 · Cited by 31 · see citing works
Role of microglia after subarachnoid hemorrhage
Lauzier, D. C., & Athiraman, U. (2024) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x241237070 · Cited by 31 · see citing works
Gu, F., Wang, Z., Ding, H., Tao, X., Zhang, J., Dai, K., Li, X., Shen, H., Li, H., Chen, Z., et al. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114950 · Cited by 28 · see citing works
Self-citationLi, J., Song, J., Jia, L., Wang, M., Ji, X., Meng, R., & Zhou, D. (2024) · Biomolecules · doi:10.3390/biom14121519 · Cited by 28 · see citing works
Exosomal microRNAs have great potential in the neurorestorative therapy for traumatic brain injury
Yang, Y., Yang, H., Yang, Y., & Ma, Y. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114026 · Cited by 27 · see citing works
Fallahi, S., Zangbar, H. S., Farajdokht, F., Rahbarghazi, R., Mohaddes, G., & Ghiasi, R. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14752 · Cited by 25 · see citing works
Sun, J., Zhu, K., Wang, Y., Wang, D.-J., Zhang, M.-Z., Sarlus, H., Benito‐Cuesta, I., Zhao, X.-Q., Zou, Z., Zhong, Q.-Y., et al. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-01000-7 · Cited by 24 · see citing works
Self-citationSong, N., Song, R., & Ma, P. (2022) · Brain and Behavior · doi:10.1002/brb3.2687 · Cited by 23 · see citing works
Chang, H., Li, Z., Zhang, W., Lin, C., Shen, Y., Zhang, G., Mao, L., Ma, C., Liu, N., & Lu, H. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01362-3 · Cited by 23 · see citing works
Modulation of inflammatory responses by fractalkine signaling in microglia
Inoue, K., Morimoto, H., Ohgidani, M., & Ueki, T. (2021) · PLOS ONE · doi:10.1371/journal.pone.0252118 · Cited by 22 · see citing works
Wang, L., Wang, Z., You, W., Yu, Z., Li, X., Shen, H., Li, H., Sun, Q., Li, W., & Chen, G. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.03.010 · Cited by 22 · see citing works
Self-citationZhang, B., Zou, Y., Tang, Q., Yuan, Z., Jiang, K., Zhang, Z., Chen, S., Wu, Q., Zhou, X., & Zhang, X. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03414-6 · Cited by 21 · see citing works
ISGylation is induced in neurons by demyelination driving ISG15-dependent microglial activation
Clarkson, B. D. S., Grund, E. M., David, K., Johnson, R. K., & Howe, C. L. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02618-4 · Cited by 21 · see citing works
MicroRNAs’ Role in Diagnosis and Treatment of Subarachnoid Hemorrhage
Segherlou, Z. H., Saldarriaga, L. A., Azizi, E., Vo, K.-A., Reddy, R., Siyanaki, M. R. H., & Lucke-Wold, B. P. (2023) · Diseases · doi:10.3390/diseases11020077 · Cited by 21 · see citing works
Vlachogiannis, P., Hillered, L., Enblad, P., & Ronne-Engström, E. (2023) · PLoS ONE · doi:10.1371/journal.pone.0282424 · Cited by 19 · see citing works
Ru, X., Qu, J., Li, Q., Zhou, J., Huang, S., Li, W., Zuo, S., Chen, Y., Liu, Z., & Feng, H. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113688 · Cited by 19 · see citing works
Luo, K., Wang, Z., Zhuang, K., Yuan, S., Liu, F., & Liu, A. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00761-9 · Cited by 17 · see citing works
Fu, W., Che, X., Tan, J., Cui, S., Ma, Y., Xu, D., Long, H., Yang, X., Wen, T., & He, Z. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14452 · Cited by 16 · see citing works
Extracellular vesicles: A new communication paradigm of complement in neurological diseases
Gu, X., Chen, A., Su, Y., You, M., Guo, H., Tan, S., He, Q., & Hu, B. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.110667 · Cited by 15 · see citing works
Exosomes in Vascular/Neurological Disorders and the Road Ahead
Alzahrani, F. A., Riza, Y. M., Eid, T. M., Almotairi, R., Scherschinski, L., Contreras, J., Nadeem, M., Perez, S. E., Raikwar, S. P., Jha, R. M., et al. (2024) · Cells · doi:10.3390/cells13080670 · Cited by 15 · see citing works
Wang, P., Dong, S., Liu, F., Liu, A., & Wang, Z. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114265 · Cited by 14 · see citing works
Ge, Y., Dou, X., Chen, P., Chen, J., Dai, M., Yao, S., & Lin, Y. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04287-1 · Cited by 13 · see citing works
Yang, Z., Li, H., Wang, J., Gao, W., Zhao, Q., Meng, Q., Huang, J., Xi, Q., Wei, J., & Yang, X. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167484 · Cited by 13 · see citing works
Self-citationWang, Y., Xu, J., You, W., Shen, H., Li, X., Yu, Z., Li, H., & Chen, G. (2022) · Molecular Brain · doi:10.1186/s13041-022-00919-6 · Cited by 12 · see citing works
Self-citationBiomarker Associations in Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage
Spantler, D., Molnár, T., Simon, D., Berki, T., Büki, A., Schwarcz, A., & Csécsei, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158789 · Cited by 12 · see citing works
Chen, X.-X., Tao, T., Liu, X.-Z., Wu, W., Wang, J., Yue, T., Li, X.-J., Zhou, Y., Gao, S., Sheng, B., et al. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01173-6 · Cited by 12 · see citing works
Self-citationNeurogenesis and Neuroinflammation in Dialogue: Mapping Gaps, Modulating Microglia, Rewiring Aging
Tanaka, M. (2026) · Cells · doi:10.3390/cells15010078 · Cited by 11 · see citing works
Liao, L., Wang, H., Wei, D., Yi, M., Gu, Y., Zhang, M., & Wang, L. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1300864 · Cited by 11 · see citing works
Yang, S., Hu, Y., Wang, X., Deng, M., Ma, J., Yin, H., Ran, Z., Luo, T., Han, G., Xiang, X., et al. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18296 · Cited by 11 · see citing works
Lü, T., Peng, S., Wang, J., Yang, S., Xu, X. M., Li, H., Shen, H., Li, X., Cui, G., & Chen, G. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.10.018 · Cited by 9 · see citing works
Self-citationAguilar-Peralta, A. K., Gonzalez-Vazquez, A., Tomás-Sanchez, C., Blanco-Álvarez, V. M., Martínez‐Fong, D., González-Barrios, J. A., Limón, I. D., Peña, L. M.-P., Flores, G., Soto-Rodríguez, G., et al. (2022) · Behavioural Neurology · doi:10.1155/2022/5388944 · Cited by 9 · see citing works
MiR-223-3p promote microglia “M2” polarization by targeting FOXO3a in subarachnoid hemorrhage
Yao, X., Bie, B., Wang, Z., Chen, Y., Sheng, L., & Li, M. (2025) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2025.578677 · Cited by 8 · see citing works
Paeoniflorin as a potential therapeutic agent for cerebrovascular diseases: A comprehensive review
Wang, Y.-R., Gao, Y., Liu, Z., Liu, W., Cui, W., Wu, H., & Xu, X.-Q. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107965 · Cited by 8 · see citing works
Self-citationLuo, M., Wang, Z., Wu, J., Xie, X., You, W., Yu, Z., Shen, H., Li, X., Li, H., Liu, Y., et al. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.03.009 · Cited by 8 · see citing works
Self-citationmiR-93-5p impairs autophagy-lysosomal pathway via TET3 after subarachnoid hemorrhage
Ding, P.-F., Liu, X.-Z., Peng, Z., Cui, Y., Liu, Y., Zhang, J.-T., Zhu, Q., Wang, J., Zhou, Y., Gao, Y., et al. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114904 · Cited by 8 · see citing works
Exosomes: A Cellular Communication Medium That Has Multiple Effects On Brain Diseases
Fang, X., Zhou, D., Wang, X., Ma, Y., Zhong, G., Jing, S., Huang, S., & Wang, Q. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-03957-4 · Cited by 7 · see citing works
Lv, Y., Li, Z., Jian, H., Wu, M., Li, X., Ruan, W., & Zhou, H. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114478 · Cited by 6 · see citing works
Self-citationLi, Y., Wu, A., Dai, W., Liu, R., Jiang, B., & Zhou, R. (2022) · Folia Neuropathologica · doi:10.5114/fn.2022.116470 · Cited by 6 · see citing works
He, Q., Zhou, T., & He, Q. (2025) · Brain Sciences · doi:10.3390/brainsci15070759 · Cited by 5 · see citing works
Shen, H., Liu, M., Zhou, H., Li, Y., Guo, Y., Yin, Y., Zhang, F., & Wang, J. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.10.014 · Cited by 5 · see citing works
Self-citationPaul, D., & Basavan, D. (2022) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-022-00446-0 · Cited by 5 · see citing works
Role of Circulating Exosomes in Cerebrovascular Diseases: A Comprehensive Review
Lu, Z., Tang, H., Li, S., Zhu, S., Li, S., & Huang, Q. (2023) · Current Neuropharmacology · doi:10.2174/1570159x21666230214112408 · Cited by 5 · see citing works
Wang, Y., Kong, X., Bao, D., xu, B., Dong, Y., Wei, X., & Niu, C. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/8979904 · Cited by 5 · see citing works
Self-citationQiu, J., Guo, L., Li, W., Wang, L., & Tong, L. (2022) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2022.102138 · Cited by 5 · see citing works
Zhang, Z., Yan, J., Chen, H., Zhao, G., Liu, L., He, J., Xia, X., Zhou, C., & Sun, X. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03811-z · Cited by 5 · see citing works
Exosomes in subarachnoid hemorrhage: A scoping review
Bhimani, A. D., Kalagara, R., Chennareddy, S., & Kellner, C. P. (2022) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2022.08.025 · Cited by 5 · see citing works
Phosphodiesterase 4 regulates pyroptosis in subarachnoid hemorrhage
Tan, J., Ma, Y., Song, R., Ye, H., Su, J., & He, Z. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01381 · Cited by 4 · see citing works
Shen, Y., Cui, J., Zhang, S., Wang, Y., Wang, J., Su, Y., Xu, D., Liu, Y., Guo, Y., & Bai, W. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.956342 · Cited by 4 · see citing works
Self-citationYang, H.-B., Lu, D.-C., Shu, M., Li, J., & Ma, Z. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114049 · Cited by 2 · see citing works
Lu, H., Xie, T., Qin, X., Wei, S., Zhao, Z., Liu, X., Wu, L., Ding, R., & Chen, Z. (2025) · Scientific Reports · doi:10.1038/s41598-025-98754-x · Cited by 2 · see citing works
Ирасханов, А. Ш., Бузиашвили, Ю. И., Кокшенева, И. В., Тугеева, Э. Ф., Голубев, Е. П., Ибрагимов, Р. М., Ibragimov, M. S., Пирцхалава, С. Д., Идрисова, З. М., Гришенок, А. В., et al. (2023) · The Bulletin of Bakoulev Center Cardiovascular Diseases · doi:10.24022/1810-0694-2023-24-5-479-491 · Cited by 1 · see citing works
Li, S., Ye, Q., Li, Y., Li, J., Peng, D., Duan, X., & Hong, S. (2025) · Journal of Visualized Experiments · doi:10.3791/68876 · Cited by 1 · see citing works
Zhang, Y., Huang, W. Z., Qin, J., Zhang, X., Zhu, A., 胡付恒, Ding, K., Wu, J., Liu, X., & Zhou, L. E. T. A. O. (2026) · Chinese Chemical Letters · doi:10.1016/j.cclet.2026.112914 · Cited by 1 · see citing works
Self-citationHuang, Z., Liu, Y., Chen, X., Yu, C., He, H., & Deng, Y. (2023) · Acta Naturae · doi:10.32607/actanaturae.11830
Self-citationResearch Progress of the Effect of microRNAs on Neuroinflammation after Intracerebral Hemorrhage
李, 铃. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.14102708
Chen, X., Tao, T., Liu, X., Wu, W., Wang, J.-W., Yue, T.-T., Li, X., Zhou, Y., Gao, S., Sheng, B., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23730820
Self-citationChang, H., Li, Z., Zhang, W., Lin, C., Shen, Y., Zhang, G., Mao, L., Ma, C., Liu, N., & Lu, H. (2024) · Figshare · doi:10.6084/m9.figshare.24934157
Chen, X., Tao, T., Liu, X., Wu, W., Wang, J.-W., Yue, T.-T., Li, X., Zhou, Y., Gao, S., Sheng, B., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23730823
Self-citationLin, S., Dai, Y., Han, C., Han, T., Zhao, L., Wu, R., Liu, J., Zhang, B., Huang, N., Liu, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26711147
Self-citationChen, X., Tao, T., Liu, X., Wu, W., Wang, J.-W., Yue, T.-T., Li, X., Zhou, Y., Gao, S., Sheng, B., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23730817
Self-citationLin, S., Dai, Y., Han, C., Han, T., Zhao, L., Wu, R., Liu, J., Zhang, B., Huang, N., Liu, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26711141
Self-citationClarkson, B. D. S., Grund, E. M., David, K., Johnson, R. K., & Howe, C. L. (2022) · Figshare · doi:10.6084/m9.figshare.21366140
Chen, X., Tao, T., Liu, X., Wu, W., Wang, J.-W., Yue, T.-T., Li, X., Zhou, Y., Gao, S., Sheng, B., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23730826
Self-citationZhang, Z. Y., Liang, F., Wen, D., Chen, H., Gu, N., Li, Z., Wang, L., Wang, Y., Pan, Q., Zhu, Y., et al. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.115667
Self-citationLi, L., Li, X., Liu, Y., Li, H., Ding, H., Lu, J., Cao, C., Yuan, J., Chen, G., & Li, H. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05810-2
Self-citationPoniatowski, Ł. A., Kwiatkowska, M., Siwińska, A., Acewicz, A., & Olczak, M. (2026) · International Journal of Legal Medicine · doi:10.1007/s00414-026-03810-4
Jiang, S., Jiang, L., Zhang, S., Zhao, X., Jiang, P., Tian, Q., Liu, C., He, P., Li, Z., Wang, G., et al. (2026) · Research · doi:10.34133/research.1301
Self-citationYe, F., Chen, R., Xu, S., Liu, H., & Xu, J. (2026) · Translational Stroke Research · doi:10.1007/s12975-026-01478-x
Zou, L.-X., Hu, H., Liu, X.-Z., shen, J., Gao, S., Ding, P.-F., Tian, K., Dong, X., Lu, X., Liu, R., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.26.747434
Self-citationYang, H., Hu, Z., Zhuang, H., Chen, S., Zhou, S., Sun, M., Lian, L., Zhou, C., Gao, X., & Huang, Y. (2026) · Neurotherapeutics · doi:10.1016/j.neurot.2026.e01099
- Authors
- Chen, X., Jiang, M., Li, H., Wang, Y., Shen, H., Li, X., Zhang, Y., Wu, J., Yu, Z., & Chen, G.
- Affiliations
- First Affiliated Hospital of Soochow University (CN)
- University of Science and Technology of China (CN)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Yu, Zhengquan
- Chen, Gang
- ORCID
- Venue
- Journal of Neuroinflammation
- Published
- 2020-07-14
- Volume
- 17
- Issue
- 1
- Pages
- 209-209
- ISSN
- 1742-2094 (ISSN-L)
- PMC
- PMC7362528
- OpenAlex
- W3043084564
- Semantic Scholar
- 675077e5abd9b06d253409b34986c413345e0135
- Cited by
- 85
- References
- 63
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 18 · 2023: 18 · 2022: 22 · 2021: 9
- FWCI
- 6.34
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Neuroinflammation (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81830036, 81771255, 81971106)
- National Key R&D Program of China (2017YFC0110304)
- Natural Science Foundation of Jiangsu Province (BK20170363, BK20180204)
- Gusu Health Personnel Training Project (GSWS2019030)
- Topics
- Health Sciences › Medicine › Neurology › Intracerebral and Subarachnoid Hemorrhage Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- subarachnoid hemorrhage, early brain injury, neuron-microglia communication, microglial activation, neuroinflammation, C/EBPα, neuroprotection, MHC class II, CD45, TNF-α, interleukin-1 alpha, neurodegeneration
- MeSH terms
- CX3C Chemokine Receptor 1, Adult, Aged, Aged, 80 and over, Animals, Brain Injuries, Cells, Cultured, Female, Humans, Male, Middle Aged, Neurons, Subarachnoid Hemorrhage, Rats, Sprague-Dawley, Microglia, Gene Transfer Techniques, MicroRNAs, Rats, Chemokine CX3CL1, Exosomes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review