CoChat
Sign Up
Cited by 28

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Interleukin-1β down-regulates the expression of metabotropic glutamate receptor 5 in cultured human astrocytes

Aronica, Eleonora, Gorter, Jan A., Rozemuller, Annemieke J., Yankaya, Bulent, Troost, Dirk·2005·Journal of Neuroimmunology
DOI 10.1016/j.jneuroim.2004.11.015
Open this paper in CoChat — free account

Abstract

Expression of metabotropic glutamate receptor 5 (mGluR5) protein is known to be plastic and to depend critically on the astrocytes' microenvironment. In the present study we investigated whether interleukins, which are involved in the immune response following brain injury, could contribute to the regulation of mGluR5 protein in human astrocytes in culture. Using Western blotting and immunocytochemistry, no detectable changes in the expression of the mGluR5 protein were observed with both interleukin 1beta and interleukin 6 in undifferentiated cultures (growing in serum free media). In contrast, in cultures that had been morphologically differentiated by exposure to epidermal growth factor (EGF), addition of interleukin 1beta (but not interleukin 6) reduced mGluR5 protein expression. In addition, stimulation of phosphoinositide hydrolysis by the selective group I agonist (S)-3,5-dihydroxyphenylglycine (DHPG) was reduced after exposure to interleukin 1beta. The suppressive effect on mGluR5 was prevented by the interleukin 1 receptor antagonist. Thus, interleukin 1beta may represent an additional pathway through which mGluR5 expression and function can be modulated in astrocytes under different pathological conditions associated with an inflammatory response.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.jneuroim.2004.11.015

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 1 references

Research works printed but not linked: 41

  1. Aarli, 2003, Role of cytokines in neurological disorders, Curr. Med. Chem., 10, 1931, 10.2174/0929867033456918 · DOI
  2. Alheim, 1998, The interleukin-1 system: receptors, ligands, and ICE in the brain and their involvement in the fever response, Ann. N. Y. Acad. Sci., 840, 51, 10.1111/j.1749-6632.1998.tb09548.x · DOI
  3. Allan, 2003, The interleukin-1 system: an attractive and viable therapeutic target in neurodegenerative disease, Curr. Drug Target. CNS Neurol. Disord., 2, 293, 10.2174/1568007033482742 · DOI
  4. Alley, 1988, Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay, Cancer Res., 48, 589
  5. Aloisi, 1992, Production of hemolymphopoietic cytokines, IL-6, IL-8, colony-stimulating factors by normal human astrocytes in response to IL-1 beta and tumor necrosis factor-alpha, J. Immunol., 149, 2358, 10.4049/jimmunol.149.7.2358 · DOI
  6. Aronica, 1993, Metabotropic glutamate receptors in cultured cerebellar granule cells: developmental profile, J. Neurochem., 60, 559, 10.1111/j.1471-4159.1993.tb03185.x · DOI
  7. Aronica, 2000, Upregulation of metabotropic glutamate receptor subtype mGluR3 and mGluR5 in reactive astrocytes in a rat model of mesial temporal lobe epilepsy, Eur. J. Neurosci., 12, 2333, 10.1046/j.1460-9568.2000.00131.x · DOI
  8. Aronica, 2001, Immunohistochemical localization of group I and II metabotropic glutamate receptors in control and amyotrophic lateral sclerosis human spinal cord: upregulation in reactive astrocytes, Neuroscience, 105, 509, 10.1016/S0306-4522(01)00181-6 · DOI
  9. Aronica, 2001, Ionotropic and metabotropic glutamate receptor protein expression in glioneuronal tumours from patients with intractable epilepsy, Neuropathol. Appl. Neurobiol., 27, 223, 10.1046/j.0305-1846.2001.00314.x · DOI
  10. Aronica, 2003, Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins, Eur. J. Neurosci., 17, 2106, 10.1046/j.1460-9568.2003.02657.x · DOI
  11. Bezzi, 1998, Prostaglandins stimulate calcium-dependent glutamate release in astrocytes, Nature, 391, 281, 10.1038/34651 · DOI
  12. Blom, 1997, NSAIDS inhibit the IL-1 beta-induced IL-6 release from human post-mortem astrocytes: the involvement of prostaglandin E2, Brain Res., 777, 210, 10.1016/S0006-8993(97)01204-3 · DOI
  13. Dinarello, 1996, Biologic basis for interleukin-1 in disease, Blood, 87, 2095, 10.1182/blood.V87.6.2095.bloodjournal8762095 · DOI · Paper page
  14. Ferraguti, 2001, Activated astrocytes in areas of kainate-induced neuronal injury upregulate the expression of the metabotropic glutamate receptors 2/3 and 5, Exp. Brain Res., 137, 1, 10.1007/s002210000633 · DOI
  15. Frohman, 1989, Astrocytes and intracerebral immune responses, J. Clin. Immunol., 9, 1, 10.1007/BF00917121 · DOI
  16. Giulian, 1994, Phagocytic microglia release cytokines and cytotoxins that regulate the survival of astrocytes and neurons in culture, Neurochem. Int., 25, 227, 10.1016/0197-0186(94)90066-3 · DOI
  17. John, 1999, IL-1beta differentially regulates calcium wave propagation between primary human fetal astrocytes via pathways involving P2 receptors and gap junction channels, Proc. Natl. Acad. Sci. U. S. A., 96, 11613, 10.1073/pnas.96.20.11613 · DOI
  18. Lee, 1993, Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta, J. Immunol., 150, 2659, 10.4049/jimmunol.150.7.2659 · DOI
  19. Miller, 1995, Growth factor upregulation of a phosphoinositide-coupled metabotropic glutamate receptor in cortical astrocytes, J. Neurosci., 15, 6103, 10.1523/JNEUROSCI.15-09-06103.1995 · DOI
  20. Minoshima, 1999, Structural organization of the mouse metabotropic glutamate receptor subtype 3 gene and its regulation by growth factors in cultured cortical astrocytes, J. Biochem. (Tokyo), 126, 889, 10.1093/oxfordjournals.jbchem.a022531 · DOI
  21. Morita, 2003, Dual regulation of calcium oscillation in astrocytes by growth factors and pro-inflammatory cytokines via the mitogen-activated protein kinase cascade, J. Neurosci., 23, 10944, 10.1523/JNEUROSCI.23-34-10944.2003 · DOI
  22. Murray, 1997, Interleukin-1 beta inhibits glutamate release in hippocampus of young, but not aged, rats, Neurobiol. Aging, 18, 343, 10.1016/S0197-4580(97)80317-X · DOI · Paper page
  23. Nakahara, 1997, The metabotropic glutamate receptor mGluR5 induces calcium oscillations in cultured astrocytes via protein kinase C phosphorylation, J. Neurochem., 69, 1467, 10.1046/j.1471-4159.1997.69041467.x · DOI
  24. Nicoletti, 1986, The activation of inositol phospholipid metabolism as a signal-transducing system for excitatory amino acids in primary cultures of cerebellar granule cells, J. Neurosci., 6, 1905, 10.1523/JNEUROSCI.06-07-01905.1986 · DOI
  25. Oprica, 2003, Inflammatory mechanisms associated with brain damage induced by kainic acid with special reference to the interleukin-1 system, J. Cell. Mol. Med., 7, 127, 10.1111/j.1582-4934.2003.tb00211.x · DOI
  26. Peltola, 2000, Interleukin-6 and interleukin-1 receptor antagonist in cerebrospinal fluid from patients with recent tonic-clonic seizures, Epilepsy Res., 41, 205, 10.1016/S0920-1211(00)00140-6 · DOI
  27. Pin, 1995, The metabotropic glutamate receptors: structure and functions, Neuropharmacology, 34, 1, 10.1016/0028-3908(94)00129-G · DOI
  28. Ponsoda, 1991, Measurement of intracellular LDH activity in 96-well cultures: a rapid and automated assay for cytotoxicity studies, J. Tissue Cult. Methods, 13, 21, 10.1007/BF02388199 · DOI
  29. Qiu, 2003, Interleukin-6, beta-amyloid peptide and NMDA interactions in rat cortical neurons, J. Neuroimmunol., 139, 51, 10.1016/S0165-5728(03)00158-9 · DOI
  30. Qiu, 1998, Chronic interleukin-6 alters NMDA receptor-mediated membrane responses and enhances neurotoxicity in developing CNS neurons, J. Neurosci., 18, 10445, 10.1523/JNEUROSCI.18-24-10445.1998 · DOI
  31. Rothwell, 2003, Interleukin-1 and neuronal injury: mechanisms, modification, and therapeutic potential, Brain Behav. Immun., 17, 152, 10.1016/S0889-1591(02)00098-3 · DOI
  32. Schoepp, 1999, Pharmacological agents acting at subtypes of metabotropic glutamate receptors, Neuropharmacology, 38, 1431, 10.1016/S0028-3908(99)00092-1 · DOI
  33. Seifert, 2001, Ionotropic glutamate receptors in astrocytes, Prog. Brain Res., 132, 287, 10.1016/S0079-6123(01)32083-6 · DOI
  34. Shintani, 1995, Role of interleukin-1 in stress responses. A putative neurotransmitter, Mol. Neurobiol., 10, 47, 10.1007/BF02740837 · DOI
  35. Tang, 2001, Expression of the group II and III metabotropic glutamate receptors in the hippocampus of patients with mesial temporal lobe epilepsy, J. Neurocytol., 30, 137, 10.1023/A:1011939223872 · DOI
  36. Tarkowski, 2003, Cerebral pattern of pro- and anti-inflammatory cytokines in dementias, Brain Res. Bull., 61, 255, 10.1016/S0361-9230(03)00088-1 · DOI · Paper page
  37. Ulas, 2000, Expression of metabotropic glutamate receptor 5 is increased in astrocytes after kainate-induced epileptic seizures, Glia, 30, 352, 10.1002/(SICI)1098-1136(200006)30:4<352::AID-GLIA40>3.0.CO;2-6 · DOI
  38. Vezzani, 2002, Functional role of inflammatory cytokines and antiinflammatory molecules in seizures and epileptogenesis, Epilepsia, 43, 30, 10.1046/j.1528-1157.43.s.5.14.x · DOI
  39. Viviani, 2003, Interleukin-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases, J. Neurosci., 23, 8692, 10.1523/JNEUROSCI.23-25-08692.2003 · DOI · Paper page
  40. Williams, 1995, Antigen presentation by human fetal astrocytes with the cooperative effect of microglia or the microglial-derived cytokine IL-1, J. Neurosci., 15, 1869, 10.1523/JNEUROSCI.15-03-01869.1995 · DOI
  41. Zhao, 1998, Involvement of cytokines in normal CNS development and neurological diseases: recent progress and perspectives, J. Neurosci. Res., 52, 7, 10.1002/(SICI)1097-4547(19980401)52:1<7::AID-JNR2>3.0.CO;2-I · DOI

Cited by

Sorted by citations

Metadata

Authors
Aronica, E., Gorter, J. A., Rozemuller, A. J., Yankaya, B., & Troost, D.
Venue
Journal of Neuroimmunology
Publisher
Elsevier BV
Published
2005-03
Volume
160
Issue
1-2
Pages
188-194
ISSN
0165-5728
DOI
10.1016/j.jneuroim.2004.11.015
Cited by
28
References
1
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review