Pro- and anti-inflammatory cytokines in the CSF of patients with creutzfeldt-jakob disease.
Abstract
We investigated cerebrospinal fluid (CSF) samples from patients with Creutzfeldt-Jakob disease (CJD) and other neurological diseases. Concentrations of pro- and anti-inflammatory cytokines IL-1beta, IL-6, IL-8, IL-12, TNF-alpha and TGF-beta 2 were determined in CSF using ELISA. Significant changes were found for IL-8 and TGF-beta 2. IL-8 levels were elevated in the CSF of CJD patients. Of interest, the increase was significant to other dementia and to controls. In contrast, TGF-beta 2 was significantly decreased in CSF of CJD compared to all groups. IL-1beta, IL-12 and TNF-alpha could not be detected in CSF or in case of IL-6 in only low concentrations without significant difference.
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IL-10 has been found to be up-regulated in human patients with CJD.
“Conversely, we found a small number of genes to increase in expression upon transfection of a miR-146a mimic. One of these was IL-10, an anti-inflammatory cytokine that can down-regulate the expression of cytokines, MHC class II molecules, and co-stimulatory molecules on macrophages, and has been found to be up-regulated in human patients with CJD [50].”
From MicroRNA 146a (miR-146a) Is Over-Expressed during Prion Disease and Modulates the Innate Immune Response and the Microglial Activation State (2012) · cites this paper as [50]
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β-amyloid, microglia, and the inflammasome in Alzheimer’s disease
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Self-citationPrion Pathogenesis in the Absence of NLRP3/ASC Inflammasomes
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- Authors
- Stoeck, K., Bodemer, M., & Zerr, I.
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2006-03
- Volume
- 172
- Issue
- 1-2
- Pages
- 175-181
- ISSN
- 0165-5728
- Cited by
- 42
- References
- 2
- Language
- en
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