Subtype and Regional-Specific Neuroinflammation in Sporadic Creutzfeldt–Jakob Disease

In silico analysis enabling informed design for genome editing in medicinal cannabis; gene families and variant characterisation

Calamita, E., Schmid, M., Kunz, M., Ndebele-Murisa, M. R., Magadza, C. H. D., Nyambe, I., & Wehrli, B. (2019) · Figshare · doi:10.26181/6153922fe919c · Cited by 4,222 · see citing works

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

Block, M. L., Zecca, L., & Hong, J.-S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2038 · Cited by 4,110 · see citing works

Signaling through the JAK/STAT pathway, recent advances and future challenges

Kisseleva, T., Bhattacharya, S., Braunstein, J., & Schindler, C. (2002) · Gene · doi:10.1016/s0378-1119(02)00398-0 · Cited by 1,158 · see citing works

NF-κB in neuronal plasticity and neurodegenerative disorders

Mattson, M. P., & Camandola, S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11916 · Cited by 877 · see citing works

Microglia: Scapegoat, saboteur, or something else?

Aguzzi, A., Barres, B. A., & Bennett, M. L. (2013) · Science · doi:10.1126/science.1227901 · Cited by 836 · see citing works

Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis

Cheng, B., Christakos, S., & Mattson, M. P. (1994) · Neuron · doi:10.1016/0896-6273(94)90159-7 · Cited by 669 · see citing works

NF-κB Is a Negative Regulator of IL-1β Secretion as Revealed by Genetic and Pharmacological Inhibition of IKKβ

Greten, F. R., Arkan, M. C., Bollrath, J., Hsu, L.-C., Goode, J., Miething, C., Göktuna, S. I., Neuenhahn, M., Fierer, J., Paxian, S., et al. (2007) · Cell · doi:10.1016/j.cell.2007.07.009 · Cited by 616 · see citing works

PrionsPreprint

Colby, D. W., & Prusiner, S. B. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a006833 · Cited by 469 · see citing works

Multiple Routes to Astrocytic Differentiation in the CNS

Rajan, P., & Mckay, R. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-10-03620.1998 · Cited by 409 · see citing works

Regulation of Microglial Proliferation during Chronic Neurodegeneration

Gómez-Nicola, D., Fransen, N. L., Suzzi, S., & Perry, V. H. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4440-12.2013 · Cited by 407 · see citing works

Inflammation and neurodegenerative diseases

Griffin, W. S. T. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.2.470s · Cited by 351 · see citing works

Neurotransmitter, peptide and cytokine processes in relation to depressive disorder: Comorbidity between depression and neurodegenerative disorders

Anisman, H., Merali, Z., & Hayley, S. P. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.01.004 · Cited by 334 · see citing works

Involvement of endoplasmic reticulum stress in the necroptosis ofmicroglia/macrophages after spinal cord injury.

王亚周 (2015) · Institutional Research Information System University of Turin (University of Turin) · doi:10.1016/j.neuroscience · Cited by 326 · see citing works

Role of complement in neurodegeneration and neuroinflammation

Bonifati, D. M., & Kishore, U. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2006.03.007 · Cited by 310 · see citing works

Synaptic changes characterize early behavioural signs in the ME7 model of murine prion disease

Cunningham, C. M., Deacon, R. M. J., Wells, H., Boche, D., Waters, S., Diniz, C. W. P., Scott, H., Rawlins, J. N. P., & Perry, V. H. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02662.x · Cited by 266 · see citing works

Incidence and spectrum of sporadic Creutzfeldt–Jakob disease variants with mixed phenotype and co-occurrence of PrPSc types: an updated classification

Parchi, P., Strammiello, R., Notari, S., Giese, A., Langeveld, J., Ladogana, A., Zerr, I., Roncaroli, F., Cras, P., Ghetti, B. F., et al. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0585-1 · Cited by 262 · see citing works

Targeting TNF-Alpha to Elucidate and Ameliorate Neuroinflammation in Neurodegenerative Diseases

Frankola, K. A., Greig, N. H., Luo, W., & Tweedie, D. (2011) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152711794653751 · Cited by 252 · see citing works

Role of microglia in neuronal cell death in prion disease

Giese, A., Brown, D. R., Groschup, M. H., Feldmann, C., Haist, I., & Kretzschmar, H. A. (1998) · Brain Pathology · doi:10.1111/j.1750-3639.1998.tb00167.x · Cited by 239 · see citing works

Consensus classification of human prion disease histotypes allows reliable identification of molecular subtypes: an inter-rater study among surveillance centres in Europe and USA

Parchi, P., de Boni, L., Saverioni, D., Cohen, M. L., Ferrer, I., Gambetti, P. L., Gelpí, E., Giaccone, G., Hauw, J., Höftberger, R., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1002-8 · Cited by 228 · see citing works

Temporary depletion of complement component C3 or genetic deficiency of C1q significantly delays onset of scrapie

Mabbott, N. A., Bruce, M. E., Botto, M., Walport, M. J., & Pepys, M. B. (2001) · Nature Medicine · doi:10.1038/86562 · Cited by 224 · see citing works

Series Introduction: JAK-STAT signaling in human disease

Schindler, C. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15644 · Cited by 217 · see citing works

PrP Deposition, Microglial Activation, and Neuronal Apoptosis in Murine Scrapie

Williams, A., Lucassen, P. J., Ritchie, D., & Bruce, M. (1997) · Experimental Neurology · doi:10.1006/exnr.1997.6424 · Cited by 204 · see citing works

Cyclooxygenase (COX)-2 Inhibitor Celecoxib Abrogates TNF-Induced NF-κB Activation through Inhibition of Activation of IκBα Kinase and Akt in Human Non-Small Cell Lung Carcinoma: Correlation with Suppression of COX-2 Synthesis

Shishodia, S., Koul, D., & Aggarwal, B. B. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.3.2011 · Cited by 185 · see citing works

Sheep and Goat BSE Propagate More Efficiently than Cattle BSE in Human PrP Transgenic Mice

Padilla, D., Béringue, V., Espinosa, J. C., Andréoletti, O., Jaumain, E., Reine, F., Herzog, L., Gutiérrez‐Adán, A., Pintado, B., Laude, H., et al. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1001319 · Cited by 156 · see citing works

A versatile prion replication assay in organotypic brain slices

Falsig, J., Julius, C., Margalith, I., Schwarz, P., Heppner, F. L., & Aguzzi, A. (2007) · Nature Neuroscience · doi:10.1038/nn2028 · Cited by 145 · see citing works

Sporadic Creutzfeldt–Jakob disease

Zerr, I., & Parchi, P. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63945-5.00009-x · Cited by 136 · see citing works

Activation of cerebral cytokine gene expression and its correlation with onset of reactive astrocyte and acute-phase response gene expression in scrapie

Campbell, I. L., Eddleston, M., Kemper, P., Oldstone, M. B. A., & Hobbs, M. V. (1994) · Journal of Virology · doi:10.1128/jvi.68.4.2383-2387.1994 · Cited by 136 · see citing works

Genes contributing to prion pathogenesis

Tamgüney, G., Giles, K., Glidden, D. V., Lessard, P., Wille, H., Tremblay, P., Groth, D., Yehiely, F., Korth, C., Moore, R. C., et al. (2008) · Journal of General Virology · doi:10.1099/vir.0.2008/001255-0 · Cited by 130 · see citing works

Expression of cytokine genes and increased nuclear factor-kappa B activity in the brains of scrapie-infected mice

Kim, J., Ju, W., Choi, J., Kim, J., Choi, E., Carp, R. I., Wı́sniewski, H. M., & Kim, Y. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00229-6 · Cited by 120 · see citing works

Characteristics of Established and Proposed Sporadic Creutzfeldt-Jakob Disease Variants

Appleby, B. S., Appleby, K. K., Crain, B. J., Onyike, C. U., Wallin, M. T., & Rabins, P. V. (2009) · Archives of Neurology · doi:10.1001/archneurol.2008.533 · Cited by 102 · see citing works

Role of interleukin-1 in prion disease-associated astrocyte activation.

Schultz, J., Schwarz, A., Neidhold, S., Burwinkel, M., Riemer, C., Simon, D., Kopf, M., Otto, M., & Baier, M. (2004) · American Journal of Pathology · doi:10.1016/s0002-9440(10)63331-7 · Cited by 101 · see citing works

The role of cytokines, astrocytes, microglia and apoptosis in Creutzfeldt-Jakob disease

Everbroeck, B. V., Dewulf, E. M., Pals, P., Lübke, U., Martin, J., & Cras, P. P. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00236-6 · Cited by 85 · see citing works

Prion pathogenesis in the absence of Toll-like receptor signalling

Prinz, M., Heikenwalder, M., Schwarz, P., Takeda, K., Akira, S., & Aguzzi, A. (2003) · The EMBO Reports · doi:10.1038/sj.embor.embor731 · Cited by 85 · see citing works

Dysregulation of brain olfactory and taste receptors in AD, PSP and CJD, and AD-related model

Ansoleaga, B., Garcia‐Esparcia, P., Llorens, F., Moreno, J., Aso, E., & Ferrer, I. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.06.034 · Cited by 84 · see citing works

Complex Deregulation and Expression of Cytokines and Mediators of the Immune Response in P arkinson's Disease Brain is Region Dependent

Garcia‐Esparcia, P., Llorens, F., Carmona, M., & Ferrer, I. (2014) · Brain Pathology · doi:10.1111/bpa.12137 · Cited by 80 · see citing works

Immunohistochemical study of microglia in the Creutzfeldt-Jakob diseased brain

Sasaki, A., Hirato, J., & Nakazato, Y. (1993) · Acta Neuropathologica · doi:10.1007/bf00369445 · Cited by 79 · see citing works

Accelerated Prion Disease in the Absence of Interleukin-10

Thackray, A. M., McKenzie, A. N. J., Klein, M. A., Lauder, A., & Bujdoso, R. (2004) · Journal of Virology · doi:10.1128/jvi.78.24.13697-13707.2004 · Cited by 77 · see citing works

Absence of Detectable IL-1β Production in Murine Prion Disease: A Model of Chronic Neurodegeneration

Walsh, D. T., Betmouni, S., & Perry, V. H. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.2.173 · Cited by 71 · see citing works

Relationship of microglia and scrapie amyloid-immunoreactive plaques in kuru, Creutzfeldt-Jakob disease and Gerstmann-Str�u�ler syndrome

Guiroy, D. C., WAKAYAMA, I., Liberski, P. P., & Gajdusek, D. C. (1994) · Acta Neuropathologica · doi:10.1007/bf00294180 · Cited by 71 · see citing works

Analysis of Protein Levels of 24 Cytokines in Scrapie Agent-Infected Brain and Glial Cell Cultures from Mice Differing in Prion Protein Expression Levels

Tribouillard‐Tanvier, D., Striebel, J. F., Peterson, K. E., & Chesebro, B. W. (2009) · Journal of Virology · doi:10.1128/jvi.01413-09 · Cited by 68 · see citing works

Reactive microgIia in Creutzfeldt‐Jakob disease

Mühleisen, H., Gehrmann, J., & Meyermann, R. (1995) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1995.tb01097.x · Cited by 63 · see citing works

Accelerated prion disease pathogenesis in toll-like receptor 4 signaling-mutant mice.

Spinner, D. S., Cho, I. S., Park, S. Y., Kim, J. I., Meeker, H. C., Ye, X., LaFauci, G., Kerr, D. J., Flory, M. J., Kim, B. S., et al. (2008) · Journal of Virology · doi:10.1128/jvi.00522-08 · Cited by 51 · see citing works

JAK‐STAT signaling pathway mediates astrogliosis in brains of scrapie‐infected mice

Na, Y., Jin, J., Kim, J., Choi, E., Carp, R. I., & Kim, Y. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04769.x · Cited by 50 · see citing works

Heightened intrathecal release of proinflammatory cytokines in Creutzfeldt–Jakob disease

Sharief, M. K., Green, A. J. E., Dick, J. P. R., Gawler, J., & Thompson, E. J. (1999) · Neurology · doi:10.1212/wnl.52.6.1289 · Cited by 48 · see citing works

PrP mRNA and protein expression in brain and PrPcin CSF in Creutzfeldt-Jakob disease MM1 and VV2

Llorens, F., Ansoleaga, B., Garcia‐Esparcia, P., Zafar, S., Grau‐Rivera, O., López‐González, I., Blanco, R., Carmona, M., Yagüe, J., Nos, C., et al. (2013) · Prion · doi:10.4161/pri.26416 · Cited by 47 · see citing works

Cyclooxygenase‐2, Prostaglandin E2, and Microglial Activation in Prion Diseases

Minghetti, L., & Pocchiari, M. (2007) · International review of neurobiology · doi:10.1016/s0074-7742(07)82014-9 · Cited by 45 · see citing works

Inducible cytokine gene expression in the brain in the ME7/CV mouse model of scrapie is highly restricted, is at a strikingly low level relative to the degree of gliosis and occurs only late in disease

Brown, A. R., Webb, J., Rebus, S., WALKER, R. E., Williams, A., & Fazakerley, J. K. (2003) · Journal of General Virology · doi:10.1099/vir.0.19137-0 · Cited by 43 · see citing works

Detection of PrPSc in subclinical BSE with the paraffin-embedded tissue (PET) blot

Schulz‐Schaeffer, W., Fatzer, R., Vandevelde, M., & Kretzschmar, H. A. (2000) · Springer eBooks · doi:10.1007/978-3-7091-6308-5_16 · Cited by 43 · see citing works

Pro- and anti-inflammatory cytokines in the CSF of patients with creutzfeldt-jakob disease.

Stoeck, K., Bodemer, M., & Zerr, I. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.10.008 · Cited by 42 · see citing works

Brain microglia were activated in sporadic CJD but almost unchanged in fatal familial insomnia and G114V genetic CJD

Shi, Q., Xie, W.-L., Zhang, B., Chen, L., Xu, Y., Wang, K., Ren, K., Zhang, X.-M., Chen, C., Zhang, J., et al. (2013) · Virology Journal · doi:10.1186/1743-422x-10-216 · Cited by 37 · see citing works

Analysis of the Hippocampal Proteome in ME7 Prion Disease Reveals a Predominant Astrocytic Signature and Highlights the Brain-restricted Production of Clusterin in Chronic Neurodegeneration

Asuni, A. A., Gray, B., Bailey, J., Skipp, P., Perry, V. H., & O'Connor, V. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.502690 · Cited by 31 · see citing works

The Toll-Like Receptor Agonist Imiquimod Is Active against Prions

Oumata, N., Nguyen, P. H., Béringue, V., Soubigou, F., Pang, Y., Desban, N., Massacrier, C., Morel, Y., Paturel, C., Contesse, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072112 · Cited by 30 · see citing works

An outline of the neuropathology of transmissible spongiform encephalopathies (prion diseases).

Liberski, P. P., & Ironside, J. W. (2004) · PubMed · Cited by 29 · see citing works

Cyclooxygenase-1 and -2 in Brains of Patients who Died with Sporadic Creutzfeldt-Jakob Disease

Deininger, M. H., Bekure, K., Trautmann, K., Morgalla, M. H., Meyermann, R., & Schluesener, H. J. (2003) · Journal of Molecular Neuroscience · doi:10.1385/jmn:20:1:25 · Cited by 27 · see citing works

Sod1 Deficiency Reduces Incubation Time in Mouse Models of Prion Disease

Akhtar, S., Grizenkova, J., Wenborn, A., Hummerich, H., de Marco, M. F., Brandner, S., Collinge, J., & Lloyd, S. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054454 · Cited by 23 · see citing works

Distribution of apoptosis-related proteins in sporadic Creutzfeldt–Jakob disease

Kovács, G. G., & Budka, H. (2010) · Brain Research · doi:10.1016/j.brainres.2010.01.089 · Cited by 22 · see citing works

Prion propagation in mice lacking central nervous system NF-κB signalling

Julius, C., Heikenwälder, M. F., Schwarz, P., Marcel, A. T. M. V. V., Karin, M., Prinz, M., Pasparakis, M., & Aguzzi, A. (2008) · Journal of General Virology · doi:10.1099/vir.0.83622-0 · Cited by 19 · see citing works

The brain immune response in human prion diseases. Microglial activation and microglial disease. I. Sporadic Creutzfeldt-Jakob disease.

Szpak, G. M., Lewandowska, E., Lechowicz, W., Wierzba‐Bobrowicz, T., Kulczycki, J., Bertrand, E., Pasennik, E., & Dymecki, J. (2006) · PubMed · Cited by 15 · see citing works

Series Introduction: JAK-STAT signaling in human disease

Schindler, C. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200215644 · Cited by 10 · see citing works

Intracerebral administration of interleukin-12 (IL-12) and IL-18 modifies the course of mouse scrapie.

Pasquali, P., Nonno, R., Mandara, M. T., Bari, M. D., Ricci, G., Petrucci, P., Capuccini, S., Cartoni, C., Macrı̀, A., & Agrimi, U. (2006) · BMC Veterinary Research · doi:10.1186/1746-6148-2-37 · Cited by 7 · see citing works

Classification of sporadic Creutzfeldt-Jakob disease based on molecular and phenotypic analysis of 300 subjects

Parchi, P., Giese, A., Capellari, S., Brown, P., Schulz-Schaeffer, W., Windl, O., Zerr, I., Budka, H., Kopp, N., Piccardo, P., et al. (1999) · Annals of Neurology · doi:10.1002/1531-8249(199908)46:2

Roles of microglia in brain development, tissue maintenance and repair

Michell‐Robinson, M. A., Touil, H., Healy, L. M., Owen, D. R., Durafourt, B. A., Bar‐Or, A., Antel, J. P., & Moore, C. S. (2015) · Brain · doi:10.1093/brain/awv066 · Cited by 421 · see citing works

YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias

Llorens, F., Thüne, K., Tahir, W., Kanata, E., Diaz-Lucena, D., Xanthopoulos, K., Kovatsi, E., Pleschka, C., Garcia-Esparcia, P., Schmitz, M., et al. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0226-4 · Cited by 249 · see citing works

Recent advances in the histo‐molecular pathology of human prion disease

Baiardi, S., Rossi, M., Capellari, S., & Parchi, P. (2018) · Brain Pathology · doi:10.1111/bpa.12695 · Cited by 143 · see citing works

Diversity of astroglial responses across human neurodegenerative disorders and brain aging

Ferrer, I. (2017) · Brain Pathology · doi:10.1111/bpa.12538 · Cited by 123 · see citing works

Genetic and Transcriptomic Profiles of Inflammation in Neurodegenerative Diseases: Alzheimer, Parkinson, Creutzfeldt-Jakob and Tauopathies

López González, I., Garcia-Esparcia, P., Llorens, F., & Ferrer, I. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020206 · Cited by 101 · see citing works

The roles of Eph receptors, neuropilin-1, P2X7, and CD147 in COVID-19-associated neurodegenerative diseases: inflammasome and JaK inhibitors as potential promising therapies

Zalpoor, H., Akbari, A., Samei, A., Forghaniesfidvajani, R., Kamali, M., Afzalnia, A., Manshouri, S., Heidari, F., Pornour, M., Khoshmirsafa, M., et al. (2022) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-022-00311-1 · Cited by 91 · see citing works

Microglia and Wnt Pathways: Prospects for Inflammation in Alzheimer’s Disease

Yang, Y., & Zhang, Z. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00110 · Cited by 76 · see citing works

Neuroinflammatory Gene Regulation, Mitochondrial Function, Oxidative Stress, and Brain Lipid Modifications With Disease Progression in Tau P301S Transgenic Mice as a Model of Frontotemporal Lobar Degeneration-Tau

López‐González, I., Aso, E., Carmona, M., Armand‐Ugón, M., Blanco, R., Naudí, A., Cabré, R., Portero‐Otín, M., Pamplona, R., & Ferrer, I. (2015) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000241 · Cited by 71 · see citing works

CSF neurogranin as a neuronal damage marker in CJD: a comparative study with AD

Blennow, K., Lucena, D. D., Zetterberg, H., Villar‐Piqué, A., Karch, A., Vidal, E., Hermann, P., Schmitz, M., Ferrer, I., Zerr, I., et al. (2019) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2018-320155 · Cited by 74 · see citing works

Molecular Mechanisms Underlying Neuroinflammation Elicited by Occupational Injuries and Toxicants

Pathak, D., & Sriram, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032272 · Cited by 69 · see citing works

The Role of Microglia in Prion Diseases: A Paradigm of Functional Diversity

Obst, J., Simon, E., Mancuso, R., & Gómez‐Nicola, D. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00207 · Cited by 59 · see citing works

Inflammation in Lafora Disease: Evolution with Disease Progression in Laforin and Malin Knock-out Mouse Models

López‐González, I., Viana, R., Sanz, P., & Ferrer, I. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9884-4 · Cited by 54 · see citing works

Inhibition of IL-1β Signaling Normalizes NMDA-Dependent Neurotransmission and Reduces Seizure Susceptibility in a Mouse Model of Creutzfeldt–Jakob Disease

Bertani, I., Iori, V., Trusel, M., Maroso, M., Foray, C., Mantovani, S., Tonini, R., Vezzani, A., & Chiesa, R. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1301-17.2017 · Cited by 54 · see citing works

microRNA-146a Signaling in Alzheimer's Disease (AD) and Prion Disease (PrD)

Lukiw, W. J. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00462 · Cited by 48 · see citing works

Altered Ca2+ homeostasis induces Calpain-Cathepsin axis activation in sporadic Creutzfeldt-Jakob disease

Llorens, F., Thüne, K., Sikorska, B., Schmitz, M., Tahir, W., Fernández‐Borges, N., Cramm, M., Gotzmann, N., Carmona, M., Streichenberger, N., et al. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0431-y · Cited by 45 · see citing works

Identification of new molecular alterations in fatal familial insomnia

Llorens, F., Thüne, K., Schmitz, M., Ansoleaga, B., Frau‐Méndez, M. A., Cramm, M., Tahir, W., Gotzmann, N., Berjaoui, S., Carmona, M., et al. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw108 · Cited by 44 · see citing works

Neuroinflammation in the dorsolateral prefrontal cortex in elderly chronic schizophrenia

López‐González, I., Pinacho, R., Vila, È., Escanilla, A., Ferrer, I., & Ramos, B. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.12.011 · Cited by 44 · see citing works

Markers of A1 astrocytes stratify to molecular sub-types in sporadic Creutzfeldt–Jakob disease brain

Ugalde, C. L., Lewis, V., Stehmann, C., McLean, C., Lawson, V., Collins, S. J., & Hill, A. F. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa029 · Cited by 34 · see citing works

TREM2 expression in the brain and biological fluids in prion diseases

Diaz-Lucena, D., Kruse, N., Thüne, K., Schmitz, M., Villar-Piqué, A., da Cunha, J. E. G., Hermann, P., López-Pérez, Ó., Andrés-Benito, P., Ladogana, A., et al. (2021) · Acta Neuropathologica · doi:10.1007/s00401-021-02296-1 · Cited by 32 · see citing works

RNA editing alterations define manifestation of prion diseases

Kanata, Ε., Llorens, F., Dafou, D., Dimitriadis, A., Thüne, K., Xanthopoulos, K., Bekas, N., Espinosa, J. C., Schmitz, M., Marín‐Moreno, A., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1803521116 · Cited by 32 · see citing works

Regional and subtype-dependent miRNA signatures in sporadic Creutzfeldt-Jakob disease are accompanied by alterations in miRNA silencing machinery and biogenesis

Llorens, F., Thüne, K., Martı́, E., Kanata, Ε., Dafou, D., Lucena, D. D., Vivancos, A. P., Shomroni, O., Zafar, S., Schmitz, M., et al. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1006802 · Cited by 32 · see citing works

Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) Correlation of Histopathology and MRI in Prion Disease

Mente, K., O’Donnell, J. K., Jones, S. E., Cohen, M. L., Thompson, N. R., Bizzi, A., Gambetti, P. L., Safar, J., & Appleby, B. S. (2017) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000188 · Cited by 31 · see citing works

Astrocytes in rare neurological conditions: Morphological and functional considerations

Ravi, K., Paidas, M. J., Saad, A. G., & Jayakumar, A. R. (2021) · The Journal of Comparative Neurology · doi:10.1002/cne.25118 · Cited by 27 · see citing works

Complex Inflammation mRNA-Related Response in ALS Is Region Dependent

Berjaoui, S., Povedano, M., Garcia‐Esparcia, P., Carmona, M., Aso, E., & Ferrer, I. (2015) · Neural Plasticity · doi:10.1155/2015/573784 · Cited by 28 · see citing works

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Prajapati, C., Singh, P., & Nand, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-36295-8.00004-3 · Cited by 1 · see citing works

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Llorens, F., Nuhn, S., Peter, C., Zerr, I., & Stoeck, K. (2015) · InTech eBooks · doi:10.5772/59652

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Hurst, M. (2009) · RePEc: Research Papers in Economics

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