Dopamine up-regulates Th17 phenotype from individuals with generalized anxiety disorder
Open accessAbstract
Our objective was to evaluate the effect of stress-related dose of dopamine (DA) on the in vitro proliferation and cytokine production in polyclonally-activated T cells from healthy individuals or individuals with generalized anxiety disorder (GAD). Our results demonstrated that cell cultures from GAD group proliferated less following T cell activation, as compared with control group. The addition of DA reduced the proliferative response in cell cultures from healthy but not from GAD individuals. The cytokine profile in GAD individuals revealed Th1 and Th2 deficiencies associated with a dominant Th17 phenotype, which was enhanced by DA. A similar DA-induced immunomodulation was also observed in PPD-activated cell cultures from GAD individuals. Unlike the control, DA-enhanced Th17 cytokine production in GAD individuals was not affected by glucocorticoid. In conclusion, our results show that the T cell functional dysregulation in GAD individuals is significantly amplified by DA. These immune abnormalities can have impact in increasing the susceptibility of individuals with anxiety disorders to infectious diseases and inflammatory/autoimmune disorders.
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In vitro activation of CD4 cells isolated from patients with generalized anxiety disorder induces them to acquire a TH17 phenotype.
“in vitro activation of CD4 cells isolated from patients with generalized anxiety disorder induces them to acquire a TH17 phenotype (Ferreira et al., 2011; Vieira et al., 2010)”
From Distinct characteristics of hippocampal pathogenic th17 cells in a mouse model of depression (2018) · cites this paper as Ferreira et al., 2011
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Distinct characteristics of hippocampal pathogenic th17 cells in a mouse model of depression
Beurel, E., Lowell, J. A., & Jope, R. S. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.04.012 · Cited by 65 · see citing works
- Authors
- Ferreira, T. B., Kasahara, T. M., Barros, P. O., Vieira, M. M. M., Bittencourt, V. C. B., Hygino, J., Andrade, R. M., Linhares, U. C., Andrade, A. F., & Bento, C. A.
- Affiliations
- Universidade Federal do Estado do Rio de Janeiro (BR)
- Universidade do Estado do Rio de Janeiro (BR)
- Corresponding author
- Bento, Cleonice A.
- ORCID
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 238
- Issue
- 1-2
- Pages
- 58-66
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W2033655746
- Cited by
- 40
- References
- 10
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 5 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 5 · 2013: 1 · 2012: 2
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- dopamine, generalized anxiety disorder, Th17 cells, T cell proliferation, cytokine production, Th1/Th2 imbalance, stress, immunomodulation, polyclonal T cell activation, PPD, glucocorticoids, T cell dysfunction
- MeSH terms
- Adolescent, Adult, Anxiety Disorders, Cell Survival, Cells, Cultured, Dopamine, Enzyme-Linked Immunosorbent Assay, Female, Flow Cytometry, Glucocorticoids, Humans, Male, Mitogens, Phenotype, Phytohemagglutinins, Thymidine, Tritium, Tuberculin, Antigens, CD, Up-Regulation, Cytokines, Cell Proliferation, Young Adult, Th17 Cells
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