The relationship between anxiety disorders and physical disorders in the U.S. National Comorbidity Survey

Sareen, Jitender; Cox, Brian J.; Clara, Ian; Asmundson, Gordon J.G.

doi:10.1002/da.20072

Cited by 389Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMental Health Treatment and AccessPsychosomatic Disorders and Their Treatments

The relationship between anxiety disorders and physical disorders in the U.S. National Comorbidity Survey

Sareen, Jitender, Cox, Brian J., Clara, Ian, Asmundson, Gordon J.G.·2005·Depression and Anxiety

DOI 10.1002/da.20072

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Abstract

Although depression has clearly been shown to be associated with physical disorders, few studies have examined whether anxiety disorders are independently associated with medical conditions after adjusting for comorbid mental disorders. We examined the relationship between anxiety disorders and a wide range of physical disorders in a nationally representative sample. Data came from the National Comorbidity Survey (N=5,877, range=age 15-54 years, response rate=82.4%). The Composite International Diagnostic Interview [Kessler et al., 1998] was used to make DSM-III-R [American Psychiatric Association, 1987] mental disorder diagnoses. Physical disorders were assessed based on a list of several conditions shown to respondents. All analyses utilized multiple logistic regression to examine the relationship between past-year anxiety disorder diagnosis and past-year chronic physical disorder. Anxiety disorders were positively associated with physical disorders even after adjusting for mood disorders, substance-use disorders, and sociodemographics. Among respondents with one or more physical disorders, a comorbid anxiety disorder diagnosis was associated with an increased likelihood of disability even after adjusting for severity of pain, comorbid mood, and substance use disorders. Among specific anxiety disorders, posttraumatic stress disorder, panic attacks, and agoraphobia were more likely to be associated with specific physical disorders than generalized anxiety disorder, social phobia, or simple phobia. There is a strong and unique association between anxiety disorders and physical disorders. Clinically, the presence of an anxiety disorder among patients with physical disorders may confer a greater level of disability.

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Chronic pain commonly coexists with depression and anxiety, and these conditions are bidirectional risk factors for one another.
“Chronic pain commonly coexists with depression and anxiety, and these conditions are bidirectional risk factors for one another [1-5].”
From Behavioral Mechanisms That Mediate Mental and Physical Health Improvements in People With Chronic Pain Who Receive a Digital Health Intervention: Prospective Cohort Pilot Study (2023) · cites this paper as [5]
There is increasing evidence to support co-occurrence of persistent pain and anxiety disorders such as generalised anxiety disorder, panic attacks, social anxiety or PTSD.
“There is also increasing evidence to support the co-occurrence of persistent pain and anxiety disorders such as generalised anxiety disorder, panic attacks, social anxiety or post-traumatic stress disorder.6–8”
From Protocol for a feasibility and acceptability study using a brief ACT-based intervention for people from Southwest Wales who live with persistent pain (2018) · cites this paper as [6]

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Authors: Sareen, J., Cox, B. J., Clara, I., & Asmundson, G. J. G.
Affiliations: University of Manitoba (CA)
University of Regina (CA)
Corresponding author: Sareen, Jitender
ORCID: Sareen, Jitender
Cox, Brian J.
Asmundson, Gordon J.G.
Venue: Depression and Anxiety
Publisher: Hindawi Limited
Published: 2005
Volume: 21
Issue: 4
Pages: 193-202
ISSN: 1091-4269 (ISSN-L)
1520-6394
DOI: 10.1002/da.20072
OpenAlex: W2049561228
Cited by: 389
References: 85
Citations by year: 2026: 8 · 2025: 49 · 2024: 11 · 2023: 18 · 2022: 12 · 2021: 28 · 2020: 11 · 2019: 9 · 2018: 16 · 2017: 11 · 2016: 14 · 2015: 23 · 2014: 33 · 2013: 22 · 2012: 21
FWCI: 19.09
Type: journal article
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 3895 d)
Locations: Depression and Anxiety (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Keywords: anxiety disorders, physical disorders, chronic physical illness, comorbidities, disability, post-traumatic stress disorder, panic disorder, agoraphobia, generalized anxiety disorder, social anxiety disorder, specific phobia, mood disorders, substance use disorders, pain intensity
MeSH terms: Adolescent, Adult, Anxiety Disorders, Female, Health Status, Humans, Male, Middle Aged, Stress Disorders, Post-Traumatic, United States, Comorbidity, Panic Disorder

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The relationship between anxiety disorders and physical disorders in the U.S. National Comorbidity Survey

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