The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
The effects of fetal and perinatal asphyxia on neuronal cytokine levels and ceramide metabolism in adulthood
Abstract
In a rat model of global fetal and perinatal asphyxia, we investigated if asphyxia and long-lasting brain tolerance to asphyxia (preconditioning) are mediated by modifications in inflammatory cytokines and ceramide metabolism genes in prefrontal cortex, hippocampus and caudate-putamen at the age of 8months. Most significant changes were found in prefrontal cortex, with reduced LAG1 homolog ceramide synthase 1 expression after both types of asphyxia. Additionally, sphingosine kinase 1 was upregulated in those animals that experienced the combination of fetal and perinatal asphyxia (preconditioning), suggesting increased cell proliferation. While cytokine levels are normal, levels of ceramide genes were modulated both after fetal and perinatal asphyxia in the adult prefrontal cortex. Moreover, the combination of two subsequent asphyctic insults provides long-lasting neuroprotection in the prefrontal cortex probably by maintaining normal apoptosis and promoting cell proliferation. Better understanding of the effects of asphyxia on ceramide metabolism will help to understand the changes leading to brain tolerance and will open opportunities for the development of new neuroprotective therapies.
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“Perinatal hypoxia can furthermore change the expression of cytokine and ceramide metabolism genes in the PFC and hampers cognitive functioning in later life [359, 360].”
From Development of prefrontal cortex (2022) · cites this paper as [359]
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Why are 4 million newborn babies dying each year?
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Development of prefrontal cortex
Kolk, S. M., & Rakic, P. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01137-9 · Cited by 378
“Perinatal hypoxia can furthermore change the expression of cytokine and ceramide metabolism genes in the PFC and hampers cognitive functioning in later life [359, 360].”
BackgroundRole of Prenatal Hypoxia in Brain Development, Cognitive Functions, and Neurodegeneration
Nalivaeva, N. N., Turner, A. J., & Zhuravin, I. A. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00825 · Cited by 181
Metadata
- Authors
- Vlassaks, E., Gavilanes, A. W. D., Vles, J. S. H., Deville, S., Kramer, B. W., Strackx, E., & Martinez-Martinez, P.
- Affiliations
- Maastricht University Medical Centre (NL)
- Maastricht University (NL)
- Corresponding author
- Gavilanes, Antonio W.D.
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 255
- Issue
- 1-2
- Pages
- 97-101
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W1967695567
- Cited by
- 12
- References
- 31
- Citations by year
- 2026: 1 · 2024: 1 · 2021: 2 · 2020: 3 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2013: 1
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion)
- Document Server@UHasselt (UHasselt) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- fetal asphyxia, perinatal asphyxia, preconditioning, inflammatory cytokines, ceramide metabolism, sphingosine kinase 1, prefrontal cortex, hippocampus, caudate-putamen, neuroprotection, apoptosis, cell proliferation, neuroinflammation
- MeSH terms
- Animals, Animals, Newborn, Asphyxia, Asphyxia Neonatorum, Ceramides, Disease Models, Animal, Female, Fetal Hypoxia, Humans, Infant, Newborn, Male, Pregnancy, Prenatal Exposure Delayed Effects, Cytokines, Rats, Sprague-Dawley, Rats
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