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Cited by 174

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Gut microbiota composition and relapse risk in pediatric MS: A pilot study

Open access
Tremlett, Helen, Fadrosh, Douglas W., Faruqi, Ali A., Hart, Janace, Roalstad, Shelly, Graves, Jennifer, Lynch, Susan, Waubant, Emmanuelle, Aaen, Greg, Belman, Anita, Benson, Leslie, Casper, Charlie, Chitnis, Tanuja, Gorman, Mark, Harris, Yolanda, Krupp, Lauren, Lotze, Tim E., Lulu, Sabina, Ness, Jayne, Olsen, Cody, Roan, Erik, Rodriguez, Moses, Rose, John, Simmons, Timothy C., Tillema, Jan-Mendelt, Weber, Wendy, Weinstock-Guttman, Bianca·2016·Journal of the Neurological Sciences
DOI 10.1016/j.jns.2016.02.042
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Abstract

We explored the association between baseline gut microbiota (16S rRNA biomarker sequencing of stool samples) in 17 relapsing-remitting pediatric MS cases and risk of relapse over a mean 19.8 months follow-up. From the Kaplan-Meier curve, 25% relapsed within an estimated 166 days from baseline. A shorter time to relapse was associated with Fusobacteria depletion (p=0.001 log-rank test), expansion of the Firmicutes (p=0.003), and presence of the Archaea Euryarchaeota (p=0.037). After covariate adjustments for age and immunomodulatory drug exposure, only absence (vs presence) of Fusobacteria was associated with relapse risk (hazard ratio=3.2 (95%CI:1.2-9.0), p=0.024). Further investigation is warranted. Findings could offer new targets to alter the MS disease course.

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Metadata

Authors
Tremlett, H., Fadrosh, D. W., Faruqi, A. A., Hart, J., Roalstad, S., Graves, J., Lynch, S., Waubant, E., Aaen, G., Belman, A., Benson, L., Casper, C., Chitnis, T., Gorman, M., Harris, Y., Krupp, L., Lotze, T. E., Lulu, S., Ness, J., Olsen, C., Roan, E., Rodriguez, M., Rose, J., Simmons, T. C., Tillema, J.-M., Weber, W., & Weinstock-Guttman, B.
Venue
Journal of the Neurological Sciences
Publisher
Elsevier BV
Published
2016-04
Volume
363
Pages
153-157
ISSN
0022-510X (ISSN-L)
DOI
10.1016/j.jns.2016.02.042
OpenAlex
W2278055304
Cited by
174
References
4
FWCI
17.98
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Gut microbiota composition and relapse risk in pediatric MS: A pilot study. https://app.cochat.ai/papers/10.1016/j.jns.2016.02.042
The paper
Tremlett, H., Fadrosh, D. W., Faruqi, A. A., Hart, J., Roalstad, S., Graves, J., Lynch, S., Waubant, E., Aaen, G., Belman, A., Benson, L., Casper, C., Chitnis, T., Gorman, M., Harris, Y., Krupp, L., Lotze, T. E., Lulu, S., Ness, J., . . . Weinstock-Guttman, B. (2016). Gut microbiota composition and relapse risk in pediatric MS: A pilot study. Journal of the Neurological Sciences. https://doi.org/10.1016/j.jns.2016.02.042

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.