Alterations of the human gut microbiome in multiple sclerosis
Open accessAbstract
The gut microbiome plays an important role in immune function and has been implicated in several autoimmune disorders. Here we use 16S rRNA sequencing to investigate the gut microbiome in subjects with multiple sclerosis (MS, n =60) and healthy controls ( n =43). Microbiome alterations in MS include increases in Methanobrevibacter and Akkermansia and decreases in Butyricimonas , and correlate with variations in the expression of genes involved in dendritic cell maturation, interferon signalling and NF-kB signalling pathways in circulating T cells and monocytes. Patients on disease-modifying treatment show increased abundances of Prevotella and Sutterella , and decreased Sarcina , compared with untreated patients. MS patients of a second cohort show elevated breath methane compared with controls, consistent with our observation of increased gut Methanobrevibacter in MS in the first cohort. Further study is required to assess whether the observed alterations in the gut microbiome play a role in, or are a consequence of, MS pathogenesis.
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Multiple sclerosis patients with active disease have an altered microbiota compared to patients in the remission phase, who have a microbiota more similar to healthy controls.
“Interestingly, even MS patients with active disease have an altered microbiota compared to patients in the remission phase, which in turn have a microbiota more similar to healthy controls (25, 134–138).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [137]
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- Authors
- Jangi, S., Gandhi, R., Cox, L. M., Li, N., von Glehn, F., Yan, R., Patel, B., Mazzola, M. A., Liu, S., Glanz, B. L., Cook, S., Tankou, S., Stuart, F., Melo, K., Nejad, P., Smith, K., Topçuolu, B. D., Holden, J., Kivisäkk, P., Chitnis, T., De Jager, P. L., Quintana, F. J., Gerber, G. K., Bry, L., & Weiner, H. L.
- Affiliations
- Brigham and Women's Hospital (US)
- University of Massachusetts Amherst (US)
- Corresponding author
- Weiner, Howard L.
- ORCID
- Venue
- Nature Communications
- Published
- 2016-06-28
- Volume
- 7
- Issue
- 1
- Pages
- 12015-12015
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC4931233
- OpenAlex
- W2461853012
- Cited by
- 1,307
- References
- 69
- Citations by year
- 2026: 92 · 2025: 123 · 2024: 148 · 2023: 132 · 2022: 160 · 2021: 160 · 2020: 163 · 2019: 120 · 2018: 105 · 2017: 89 · 2016: 14
- FWCI
- 56.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Multiple Sclerosis Society
- Brigham and Women's Hospital (NS087226)
- Multiple Sclerosis Society
- National Institutes of Health (DK034854)
- Harvard Digestive Diseases Center, Harvard University (DK034854)
- National Institute of Allergy and Infectious Diseases (R01AI126880)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK034854)
- National Institute of Neurological Disorders and Stroke (R01NS087226, R21NS087867)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Keywords
- multiple sclerosis, gut microbiota, Methanobrevibacter, Akkermansia, Butyricimonas, Prevotella, Sutterella, Sarcina, breath methane, dendritic cell maturation, interferon signaling, NF-κB signaling, disease-modifying therapy, peripheral blood T cells, monocytes, autoimmune disease
- MeSH terms
- Gastrointestinal Microbiome, Adult, Breath Tests, Female, Genes, Bacterial, Humans, Male, Methane, Middle Aged, Monocytes, Phylogeny, RNA, Ribosomal, 16S, T-Lymphocytes, Case-Control Studies, Multiple Sclerosis, Relapsing-Remitting, Immunomodulation
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Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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