Zinc deficiency, DNA damage and cancer risk
Abstract
A large body of evidence suggests that a significant percentage of deaths resulting from cancer in the United States could be avoided through greater attention to proper and adequate nutrition. Although many dietary compounds have been suggested to contribute to the prevention of cancer, there is strong evidence to support the fact that zinc, a key constituent or cofactor of over 300 mammalian proteins, may be of particular importance in host defense against the initiation and progression of cancer. Remarkably, 10% of the U.S. population consumes less than half the recommended dietary allowance for zinc and are at increased risk for zinc deficiency. Zinc is known to be an essential component of DNA-binding proteins with zinc fingers, as well as copper/zinc superoxide dismutase and several proteins involved in DNA repair. Thus, zinc plays an important role in transcription factor function, antioxidant defense and DNA repair. Dietary deficiencies in zinc can contribute to single- and double-strand DNA breaks and oxidative modifications to DNA that increase risk for cancer development. This review will focus on potential mechanisms by which zinc deficiency impairs host protective mechanisms designed to protect against DNA damage, enhances susceptibility to DNA-damaging agents and ultimately increases risk for cancer.
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As interacts with DNA repair proteins possessing functional zinc finger motifs.
“As interacts with DNA repair proteins possessing functional zinc finger motifs, which are involved in transcription, DNA repair proteins, and DNA-protein and protein-protein binding [105, 106].”
From Arsenic Contamination of Groundwater: A Review of Sources, Prevalence, Health Risks, and Strategies for Mitigation (2014) · cites this paper as [105]
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- Authors
- Ho, E.
- Affiliations
- Oregon State University (US)
- Corresponding author
- Ho, Emily
- ORCID
- Ho, Emily
- Venue
- The Journal of Nutritional Biochemistry
- Publisher
- Elsevier BV
- Published
- 2004-10
- Volume
- 15
- Issue
- 10
- Pages
- 572-578
- ISSN
- 0955-2863 (ISSN-L)
- OpenAlex
- W2130318636
- Cited by
- 518
- References
- 91
- Citations by year
- 2026: 16 · 2025: 15 · 2024: 35 · 2023: 33 · 2022: 23 · 2021: 24 · 2020: 34 · 2019: 27 · 2018: 30 · 2017: 22 · 2016: 18 · 2015: 28 · 2014: 33 · 2013: 24 · 2012: 25
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Nutritional Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Micronutrient Interactions and Effects
- Keywords
- zinc deficiency, DNA damage, cancer risk, zinc finger, copper-zinc superoxide dismutase, DNA repair, antioxidant defense, transcription factors, oxidative DNA damage, DNA strand breaks, zinc intake, cancer prevention, host defense against cancer
- MeSH terms
- DNA Damage, DNA Repair, Humans, Neoplasms, Nutritional Physiological Phenomena, Risk Factors, Zinc, Signal Transduction, Apoptosis, Oxidative Stress
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